Chromosomal localization of two human genes involved in phosphate homeostasis: The type IIb sodium-phosphate cotransporter and stanniocalcin-2

Kenneth E. White, Jurg Biber, Heini Murer, Michael J. Econs

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Extracellular phosphate concentrations are maintained by coordinated regulation of specific homeostatic mechanisms. A novel gene, the type IIb sodium-phosphate cotransporter (Npt2b), was recently cloned and is expressed within intestinal tissues, indicating that the transporter may be an important regulator of phosphate reabsorption. Another gene, human stanniocalcin-2 (STC2), was previously shown to decrease phosphate uptake into kidney cells in vitro. Because of the important role that STC2 may play in phosphate homeostasis, we considered the peptide hormone a candidate for the phosphate wasting disease autosomal dominant hypophosphatemic rickets (ADHR), previously localized to chromosome 12p13. The purpose of our study was to determine the chromosomal localization of human NPT2b and STC2. In the present work, NPT2b was localized to human chromosome 4p15-p16, and STC2 to 5q33-tel. Because STC2 did not map to 12p13, the hormone was excluded as the ADHR gene, however it should be considered a candidate for other diseases involving phosphate homeostasis.

Original languageEnglish (US)
Pages (from-to)357-362
Number of pages6
JournalSomatic Cell and Molecular Genetics
Volume24
Issue number6
DOIs
StatePublished - Jan 1 1998

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

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