Chronic alcohol consumption in alcohol-preferring P rats attenuates subsequent conditioned taste aversion produced by ethanol injections

R. B. Stewart, W. J. McBride, L. Lumeng, T. K. Li, J. M. Murphy

Research output: Contribution to journalArticle

63 Scopus citations

Abstract

Rats of the P line were tested for the development of tolerance to the aversive effects of ethanol during 33 days of continuous availability of food, water and a 10% (v/v) ethanol solution. Beginning on the day following the removal of ethanol, five daily conditioned taste aversion (CTA) trials were administered to the ethanol-drinking P rats and an ethanol-naive control group. The CTA trials consisted of a 20-min access to a Polycose solution, followed by IP injection of saline, 0.5, 1.0, or 1.5 g ethanol/kg. The ethanol-drinking rats developed a preference for the Polycose solution when it was paired with 0.5 g ethanol injections, but the control rats did not. Both control and ethanol groups had similar CTAs at the 1.5 g dose. However, at the 1.0 g dose, the ethanol group had an attenuated CTA compared with the water control group. The results suggest that P rats develop tolerance to aversive effects of ethanol during chronic drinking. This tolerance could contribute to the high ethanol intake in these selectively-bred rats.

Original languageEnglish (US)
Pages (from-to)530-534
Number of pages5
JournalPsychopharmacology
Volume105
Issue number4
DOIs
StatePublished - Dec 1 1991

Keywords

  • Alcohol-preferring P rats
  • Chronic ethanol drinking
  • Conditioned taste aversion
  • Tolerance

ASJC Scopus subject areas

  • Pharmacology

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