Chronic Exposure to Aluminum in Drinking Water Increases Inflammatory Parameters Selectively in the Brain

Arezoo Campbell, A. Becaria, D. K. Lahiri, K. Sharman, S. C. Bondy

Research output: Contribution to journalArticle

127 Scopus citations

Abstract

A link between aluminum (Al) exposure and age-related neurological disorders has long been proposed. Although the exact mechanism by which the metal may influence disease processes is unknown, there is evidence that exposure to Al causes an increase in both oxidative stress and inflammatory events. These processes have also been suggested to play a role in Alzheimer's disease (AD), and exposure to the metal may contribute to the disorder by potentiating these events. Al lactate (0.01, 0.1, and 1 mM) in drinking water for 10 weeks increased inflammatory processes in the brains of mice. The lowest of these levels is in the range found to increase the prevalence of AD in regions where the concentrations of the metal are elevated in residential drinking water (Flaten [2001] Brain Res. Bull. 55:187-196). Nuclear factor-κB as well as tumor necrosis factor-α (TNF-α) and interleukin 1α. (IL-1α) levels were increased in the brains of treated animals. The mRNA for TNF-α was also up-regulated following treatment. Enhancement of glial fibrillary acidic protein levels and reactive microglia was seen in the striatum of Al-treated animals. The level of amyloid beta (Aβ40) was not significantly altered in the brains of exposed animals. Insofar as no parallel changes were observed in the serum or liver of treated animals, the proinflammatory effects of the metal may be selective to the brain. Al exposure may not be sufficient to cause abnormal production of the principal component of senile plaques directly but does exacerbate underlying events associated with brain aging and thus could contribute to progression of neurodegeneration.

Original languageEnglish (US)
Pages (from-to)565-572
Number of pages8
JournalJournal of Neuroscience Research
Volume75
Issue number4
DOIs
StatePublished - Feb 15 2004

Keywords

  • Aging
  • Alzheimer's disease
  • Amyloid beta
  • Inflammatory cytokines
  • Microglial activation

ASJC Scopus subject areas

  • Neuroscience(all)

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