Chronic Kidney Disease-Mineral-Bone Disorder

A New Paradigm

Sharon Moe, Tilman Drüeke, Norbert Lameire, Garabed Eknoyan

Research output: Contribution to journalArticle

150 Citations (Scopus)

Abstract

Disturbances in mineral and bone metabolism are prevalent in chronic kidney disease (CKD) and an important cause of morbidity, decreased quality of life, and extraskeletal calcification that have been associated with increased cardiovascular mortality. These disturbances have traditionally been termed renal osteodystrophy and classified on the basis of bone biopsy. Kidney Disease: Improving Global Outcomes (KDIGO) recently sponsored a Controversies Conference to evaluate this definition. The recommendations were that (1) the term renal osteodystrophy be used exclusively to define alterations in bone morphology associated with CKD and (2) the term CKD-mineral and bone disorder (CKD-MBD) be used to describe the broader clinical syndrome that develops as a systemic disorder of mineral and bone metabolism as a result of CKD. CKD-MBD is manifested by an abnormality of any one or a combination of the following: laboratory-abnormalities of calcium, phosphorus, PTH, or vitamin D metabolism; bone-changes in bone turnover, mineralization, volume, linear growth, or strength; and calcification-vascular or other soft-tissue calcification. The pathogenesis and clinical manifestations of these components of CKD-MBD are described in detail in this issue of Advances in Chronic Kidney Disease.

Original languageEnglish
Pages (from-to)3-12
Number of pages10
JournalAdvances in Chronic Kidney Disease
Volume14
Issue number1
DOIs
StatePublished - Jan 2007

Fingerprint

Chronic Kidney Disease-Mineral and Bone Disorder
Chronic Renal Insufficiency
Bone and Bones
Minerals
Vascular Calcification
Physiologic Calcification
Bone Remodeling
Kidney Diseases
Vitamin D
Phosphorus
Quality of Life
Calcium
Morbidity
Biopsy
Mortality
Growth

Keywords

  • calcium
  • CKD
  • mineral-bone bisorder
  • parathyroid hormone
  • phosphorus
  • renal osteodystrophy
  • vascular calcification
  • vitamin D

ASJC Scopus subject areas

  • Nephrology

Cite this

Chronic Kidney Disease-Mineral-Bone Disorder : A New Paradigm. / Moe, Sharon; Drüeke, Tilman; Lameire, Norbert; Eknoyan, Garabed.

In: Advances in Chronic Kidney Disease, Vol. 14, No. 1, 01.2007, p. 3-12.

Research output: Contribution to journalArticle

Moe, Sharon ; Drüeke, Tilman ; Lameire, Norbert ; Eknoyan, Garabed. / Chronic Kidney Disease-Mineral-Bone Disorder : A New Paradigm. In: Advances in Chronic Kidney Disease. 2007 ; Vol. 14, No. 1. pp. 3-12.
@article{1fe998c17a314885ababa06723abd6e1,
title = "Chronic Kidney Disease-Mineral-Bone Disorder: A New Paradigm",
abstract = "Disturbances in mineral and bone metabolism are prevalent in chronic kidney disease (CKD) and an important cause of morbidity, decreased quality of life, and extraskeletal calcification that have been associated with increased cardiovascular mortality. These disturbances have traditionally been termed renal osteodystrophy and classified on the basis of bone biopsy. Kidney Disease: Improving Global Outcomes (KDIGO) recently sponsored a Controversies Conference to evaluate this definition. The recommendations were that (1) the term renal osteodystrophy be used exclusively to define alterations in bone morphology associated with CKD and (2) the term CKD-mineral and bone disorder (CKD-MBD) be used to describe the broader clinical syndrome that develops as a systemic disorder of mineral and bone metabolism as a result of CKD. CKD-MBD is manifested by an abnormality of any one or a combination of the following: laboratory-abnormalities of calcium, phosphorus, PTH, or vitamin D metabolism; bone-changes in bone turnover, mineralization, volume, linear growth, or strength; and calcification-vascular or other soft-tissue calcification. The pathogenesis and clinical manifestations of these components of CKD-MBD are described in detail in this issue of Advances in Chronic Kidney Disease.",
keywords = "calcium, CKD, mineral-bone bisorder, parathyroid hormone, phosphorus, renal osteodystrophy, vascular calcification, vitamin D",
author = "Sharon Moe and Tilman Dr{\"u}eke and Norbert Lameire and Garabed Eknoyan",
year = "2007",
month = "1",
doi = "10.1053/j.ackd.2006.10.005",
language = "English",
volume = "14",
pages = "3--12",
journal = "Advances in Chronic Kidney Disease",
issn = "1548-5595",
publisher = "W.B. Saunders Ltd",
number = "1",

}

TY - JOUR

T1 - Chronic Kidney Disease-Mineral-Bone Disorder

T2 - A New Paradigm

AU - Moe, Sharon

AU - Drüeke, Tilman

AU - Lameire, Norbert

AU - Eknoyan, Garabed

PY - 2007/1

Y1 - 2007/1

N2 - Disturbances in mineral and bone metabolism are prevalent in chronic kidney disease (CKD) and an important cause of morbidity, decreased quality of life, and extraskeletal calcification that have been associated with increased cardiovascular mortality. These disturbances have traditionally been termed renal osteodystrophy and classified on the basis of bone biopsy. Kidney Disease: Improving Global Outcomes (KDIGO) recently sponsored a Controversies Conference to evaluate this definition. The recommendations were that (1) the term renal osteodystrophy be used exclusively to define alterations in bone morphology associated with CKD and (2) the term CKD-mineral and bone disorder (CKD-MBD) be used to describe the broader clinical syndrome that develops as a systemic disorder of mineral and bone metabolism as a result of CKD. CKD-MBD is manifested by an abnormality of any one or a combination of the following: laboratory-abnormalities of calcium, phosphorus, PTH, or vitamin D metabolism; bone-changes in bone turnover, mineralization, volume, linear growth, or strength; and calcification-vascular or other soft-tissue calcification. The pathogenesis and clinical manifestations of these components of CKD-MBD are described in detail in this issue of Advances in Chronic Kidney Disease.

AB - Disturbances in mineral and bone metabolism are prevalent in chronic kidney disease (CKD) and an important cause of morbidity, decreased quality of life, and extraskeletal calcification that have been associated with increased cardiovascular mortality. These disturbances have traditionally been termed renal osteodystrophy and classified on the basis of bone biopsy. Kidney Disease: Improving Global Outcomes (KDIGO) recently sponsored a Controversies Conference to evaluate this definition. The recommendations were that (1) the term renal osteodystrophy be used exclusively to define alterations in bone morphology associated with CKD and (2) the term CKD-mineral and bone disorder (CKD-MBD) be used to describe the broader clinical syndrome that develops as a systemic disorder of mineral and bone metabolism as a result of CKD. CKD-MBD is manifested by an abnormality of any one or a combination of the following: laboratory-abnormalities of calcium, phosphorus, PTH, or vitamin D metabolism; bone-changes in bone turnover, mineralization, volume, linear growth, or strength; and calcification-vascular or other soft-tissue calcification. The pathogenesis and clinical manifestations of these components of CKD-MBD are described in detail in this issue of Advances in Chronic Kidney Disease.

KW - calcium

KW - CKD

KW - mineral-bone bisorder

KW - parathyroid hormone

KW - phosphorus

KW - renal osteodystrophy

KW - vascular calcification

KW - vitamin D

UR - http://www.scopus.com/inward/record.url?scp=33845745462&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33845745462&partnerID=8YFLogxK

U2 - 10.1053/j.ackd.2006.10.005

DO - 10.1053/j.ackd.2006.10.005

M3 - Article

VL - 14

SP - 3

EP - 12

JO - Advances in Chronic Kidney Disease

JF - Advances in Chronic Kidney Disease

SN - 1548-5595

IS - 1

ER -