Chronic kidney disease-mineral bone disorder: Definitions and rationale for a systemic disorder

Kraiwiporn Kiattisunthorn, Sharon Moe

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Over the past decade there has been an increasing awareness of the complexity of bone and mineral complications observed in chronic kidney disease (CKD) and recognition that the consequences of these abnormalities affect not only the skeleton, but also the cardiovascular system. These scientific advances led to the naming of a systemic disorder, "Chronic Kidney Disease-Mineral Bone Disorder" (CKD-MBD) defined as abnormalities in mineral-related biochemistries, bone modeling/remodeling and strength, and extraskeletal calcification. CKD-MBD begins early in the course of progressive CKD, at estimated glomerular filtration rates of 60 ml/min or earlier, with progression such that all dialysis patients have one or more components. The older term, renal osteodystrophy is one component of CKD-MBD and should be used exclusively to define the histopathologic abnormalities of CKD-related bone remodeling. This diagnostic criteria has been further refined using a new classification system "turnover, mineralization, and volume", that defines bone turnover, mineralization, and volume to allow for a more complete evaluation of renal osteodystrophy. The recognition of this inter-relationship between biochemical changes, bone, and extraskeletal calcification as the systemic disorder CKD-MBD allows for enhanced communication, increased awareness/diagnosis, and improved treatment approaches with the ultimate goal of improving morbidity and mortality in patients with CKD.

Original languageEnglish
Pages (from-to)119-127
Number of pages9
JournalClinical Reviews in Bone and Mineral Metabolism
Volume10
Issue number3
DOIs
StatePublished - Sep 2012

Fingerprint

Chronic Kidney Disease-Mineral and Bone Disorder
Chronic Renal Insufficiency
Bone Remodeling
Minerals
Bone and Bones
Physiologic Calcification
Cardiovascular System
Glomerular Filtration Rate
Skeleton
Biochemistry
Dialysis
Communication
Morbidity
Mortality

Keywords

  • Bone
  • Calcium
  • Phosphorus
  • Vascular calcification

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine

Cite this

Chronic kidney disease-mineral bone disorder : Definitions and rationale for a systemic disorder. / Kiattisunthorn, Kraiwiporn; Moe, Sharon.

In: Clinical Reviews in Bone and Mineral Metabolism, Vol. 10, No. 3, 09.2012, p. 119-127.

Research output: Contribution to journalArticle

@article{f631e45322034d7fba559610df0fd181,
title = "Chronic kidney disease-mineral bone disorder: Definitions and rationale for a systemic disorder",
abstract = "Over the past decade there has been an increasing awareness of the complexity of bone and mineral complications observed in chronic kidney disease (CKD) and recognition that the consequences of these abnormalities affect not only the skeleton, but also the cardiovascular system. These scientific advances led to the naming of a systemic disorder, {"}Chronic Kidney Disease-Mineral Bone Disorder{"} (CKD-MBD) defined as abnormalities in mineral-related biochemistries, bone modeling/remodeling and strength, and extraskeletal calcification. CKD-MBD begins early in the course of progressive CKD, at estimated glomerular filtration rates of 60 ml/min or earlier, with progression such that all dialysis patients have one or more components. The older term, renal osteodystrophy is one component of CKD-MBD and should be used exclusively to define the histopathologic abnormalities of CKD-related bone remodeling. This diagnostic criteria has been further refined using a new classification system {"}turnover, mineralization, and volume{"}, that defines bone turnover, mineralization, and volume to allow for a more complete evaluation of renal osteodystrophy. The recognition of this inter-relationship between biochemical changes, bone, and extraskeletal calcification as the systemic disorder CKD-MBD allows for enhanced communication, increased awareness/diagnosis, and improved treatment approaches with the ultimate goal of improving morbidity and mortality in patients with CKD.",
keywords = "Bone, Calcium, Phosphorus, Vascular calcification",
author = "Kraiwiporn Kiattisunthorn and Sharon Moe",
year = "2012",
month = "9",
doi = "10.1007/s12018-011-9119-1",
language = "English",
volume = "10",
pages = "119--127",
journal = "Clinical Reviews in Bone and Mineral Metabolism",
issn = "1534-8644",
publisher = "Humana Press",
number = "3",

}

TY - JOUR

T1 - Chronic kidney disease-mineral bone disorder

T2 - Definitions and rationale for a systemic disorder

AU - Kiattisunthorn, Kraiwiporn

AU - Moe, Sharon

PY - 2012/9

Y1 - 2012/9

N2 - Over the past decade there has been an increasing awareness of the complexity of bone and mineral complications observed in chronic kidney disease (CKD) and recognition that the consequences of these abnormalities affect not only the skeleton, but also the cardiovascular system. These scientific advances led to the naming of a systemic disorder, "Chronic Kidney Disease-Mineral Bone Disorder" (CKD-MBD) defined as abnormalities in mineral-related biochemistries, bone modeling/remodeling and strength, and extraskeletal calcification. CKD-MBD begins early in the course of progressive CKD, at estimated glomerular filtration rates of 60 ml/min or earlier, with progression such that all dialysis patients have one or more components. The older term, renal osteodystrophy is one component of CKD-MBD and should be used exclusively to define the histopathologic abnormalities of CKD-related bone remodeling. This diagnostic criteria has been further refined using a new classification system "turnover, mineralization, and volume", that defines bone turnover, mineralization, and volume to allow for a more complete evaluation of renal osteodystrophy. The recognition of this inter-relationship between biochemical changes, bone, and extraskeletal calcification as the systemic disorder CKD-MBD allows for enhanced communication, increased awareness/diagnosis, and improved treatment approaches with the ultimate goal of improving morbidity and mortality in patients with CKD.

AB - Over the past decade there has been an increasing awareness of the complexity of bone and mineral complications observed in chronic kidney disease (CKD) and recognition that the consequences of these abnormalities affect not only the skeleton, but also the cardiovascular system. These scientific advances led to the naming of a systemic disorder, "Chronic Kidney Disease-Mineral Bone Disorder" (CKD-MBD) defined as abnormalities in mineral-related biochemistries, bone modeling/remodeling and strength, and extraskeletal calcification. CKD-MBD begins early in the course of progressive CKD, at estimated glomerular filtration rates of 60 ml/min or earlier, with progression such that all dialysis patients have one or more components. The older term, renal osteodystrophy is one component of CKD-MBD and should be used exclusively to define the histopathologic abnormalities of CKD-related bone remodeling. This diagnostic criteria has been further refined using a new classification system "turnover, mineralization, and volume", that defines bone turnover, mineralization, and volume to allow for a more complete evaluation of renal osteodystrophy. The recognition of this inter-relationship between biochemical changes, bone, and extraskeletal calcification as the systemic disorder CKD-MBD allows for enhanced communication, increased awareness/diagnosis, and improved treatment approaches with the ultimate goal of improving morbidity and mortality in patients with CKD.

KW - Bone

KW - Calcium

KW - Phosphorus

KW - Vascular calcification

UR - http://www.scopus.com/inward/record.url?scp=84865727552&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865727552&partnerID=8YFLogxK

U2 - 10.1007/s12018-011-9119-1

DO - 10.1007/s12018-011-9119-1

M3 - Article

AN - SCOPUS:84865727552

VL - 10

SP - 119

EP - 127

JO - Clinical Reviews in Bone and Mineral Metabolism

JF - Clinical Reviews in Bone and Mineral Metabolism

SN - 1534-8644

IS - 3

ER -