Chronic lung allograft rejection and airway microvasculature

Is HIF-1 the missing link?

David S. Wilkes

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Chronic lung allograft rejection, known as obliterative bronchiolitis (OB), is the leading cause of death in lung transplant patients. Although OB pathogenesis is not fully understood, in this issue of the JCI, Jiang and colleagues report that tissue hypoxia resulting in dysfunctional airway microvasculature precedes the airway fibrosis characteristic of OB. In addition, a relative deficiency of allograft endothelial cell-derived HIF-1α contributes to this process. Data showing that overexpressing HIF-1α restores the microvascular airway normoxia and prevents airway fibrosis highlight a novel role for vascular biology in OB pathogenesis.

Original languageEnglish
Pages (from-to)2155-2157
Number of pages3
JournalJournal of Clinical Investigation
Volume121
Issue number6
DOIs
StatePublished - Jun 1 2011

Fingerprint

Bronchiolitis
Microvessels
Allografts
Lung
Fibrosis
Blood Vessels
Cause of Death
Endothelial Cells
Transplants

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Chronic lung allograft rejection and airway microvasculature : Is HIF-1 the missing link? / Wilkes, David S.

In: Journal of Clinical Investigation, Vol. 121, No. 6, 01.06.2011, p. 2155-2157.

Research output: Contribution to journalArticle

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