Chronic lymphocytic leukemia in relation to chemical exposures

Kathleen E. Malone, Thomas D. Koepsell, Janet R. Daling, Noel S. Weiss, Peter D. Morris, John W. Taylor, G. Marie Swanson, J. Lynn Lyon

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

As part of a population-based case-control study carried out in four areas of the United States, 427 cases of chronic lymphocytic leukemia diagnosed between July 1, 1977, and December 31, 1981, and 1,683 controls were interviewed regarding their history of chemical exposure. Respondents were asked if they had ever been "highly exposed" at home, at work, or elsewhere to one or more of a list of chemicals or to any other such substances not on the list. These chemicals were categorized into 20 exposure groups based on chemical composition. Odds ratios were calculated adjusting for age, sex, race, education level, and geographic location by means of unconditional logistic regression. Increased risks were associated with reported past exposure to acid-containing chemicals, "other caustic substances," aliphatic hydrocarbons, and chlorinated hydrocarbons. Because of the large number of exposures investigated in this study, and because of the relatively imprecise means the authors had to assess exposure, further research is needed to verify these findings.

Original languageEnglish (US)
Pages (from-to)1152-1158
Number of pages7
JournalAmerican Journal of Epidemiology
Volume130
Issue number6
StatePublished - Dec 1989
Externally publishedYes

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Chlorinated Hydrocarbons
Geographic Locations
Caustics
Sex Education
B-Cell Chronic Lymphocytic Leukemia
Hydrocarbons
Case-Control Studies
Logistic Models
Odds Ratio
Acids
Research
Population
Surveys and Questionnaires

Keywords

  • Environmental exposure
  • Leukemia
  • Lymphocytic
  • Occupational diseases

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Epidemiology

Cite this

Malone, K. E., Koepsell, T. D., Daling, J. R., Weiss, N. S., Morris, P. D., Taylor, J. W., ... Lyon, J. L. (1989). Chronic lymphocytic leukemia in relation to chemical exposures. American Journal of Epidemiology, 130(6), 1152-1158.

Chronic lymphocytic leukemia in relation to chemical exposures. / Malone, Kathleen E.; Koepsell, Thomas D.; Daling, Janet R.; Weiss, Noel S.; Morris, Peter D.; Taylor, John W.; Swanson, G. Marie; Lyon, J. Lynn.

In: American Journal of Epidemiology, Vol. 130, No. 6, 12.1989, p. 1152-1158.

Research output: Contribution to journalArticle

Malone, KE, Koepsell, TD, Daling, JR, Weiss, NS, Morris, PD, Taylor, JW, Swanson, GM & Lyon, JL 1989, 'Chronic lymphocytic leukemia in relation to chemical exposures', American Journal of Epidemiology, vol. 130, no. 6, pp. 1152-1158.
Malone KE, Koepsell TD, Daling JR, Weiss NS, Morris PD, Taylor JW et al. Chronic lymphocytic leukemia in relation to chemical exposures. American Journal of Epidemiology. 1989 Dec;130(6):1152-1158.
Malone, Kathleen E. ; Koepsell, Thomas D. ; Daling, Janet R. ; Weiss, Noel S. ; Morris, Peter D. ; Taylor, John W. ; Swanson, G. Marie ; Lyon, J. Lynn. / Chronic lymphocytic leukemia in relation to chemical exposures. In: American Journal of Epidemiology. 1989 ; Vol. 130, No. 6. pp. 1152-1158.
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