Chronic proliferative dermatitis in mice: Neutrophil-endothelium interactions and the role of adhesion molecules

H. I. Gallardo Torres, M. J.J. Gijbels, H. Hogenesch, G. Kraal

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The murine chronic proliferative dermatitis mutation (cpdm/cpdm) is characterized by epidermal hyperplasia and hyperproliferation of ventral and dorsal skin sites. The expression of endothelium-associated adhesion molecules was studied in combination with the binding capacity of various cell types on frozen sections of the affected skin. In correlation with the relative absence of lymphocytes in the cpdm/cpdm skin no lymphocyte binding could be observed, but avid adhesion of neutrophils was seen. Binding of neutrophils could be blocked with antibodies against L-selectin, LFA-1, CR3 and anti ICAM-1. No expression of vascular addressins or E-selectin on endothelium in the dermis was found. The cpdm/cpdm mutation has therefore characteristics of a psoriasis-like as well as a more generalized inflammatory skin condition.

Original languageEnglish (US)
Pages (from-to)341-347
Number of pages7
JournalPathobiology
Volume63
Issue number6
DOIs
StatePublished - Jan 1 1995

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Keywords

  • Adhesion molecules
  • Hyperproliferation
  • Neutrophil
  • Skin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

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