Chronic proliferative dermatitis in mice

Neutrophil-endothelium interactions and the role of adhesion molecules

H. I. Gallardo Torres, M. J J Gijbels, Harm HogenEsch, G. Kraal

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The murine chronic proliferative dermatitis mutation (cpdm/cpdm) is characterized by epidermal hyperplasia and hyperproliferation of ventral and dorsal skin sites. The expression of endothelium-associated adhesion molecules was studied in combination with the binding capacity of various cell types on frozen sections of the affected skin. In correlation with the relative absence of lymphocytes in the cpdm/cpdm skin no lymphocyte binding could be observed, but avid adhesion of neutrophils was seen. Binding of neutrophils could be blocked with antibodies against L-selectin, LFA-1, CR3 and anti ICAM-1. No expression of vascular addressins or E-selectin on endothelium in the dermis was found. The cpdm/cpdm mutation has therefore characteristics of a psoriasis-like as well as a more generalized inflammatory skin condition.

Original languageEnglish (US)
Pages (from-to)341-347
Number of pages7
JournalPathobiology
Volume63
Issue number6
DOIs
StatePublished - 1995
Externally publishedYes

Fingerprint

Dermatitis
Endothelium
Skin
Neutrophils
Adhesion
Molecules
Lymphocytes
L-Selectin
Lymphocyte Function-Associated Antigen-1
Mutation
E-Selectin
Frozen Sections
Intercellular Adhesion Molecule-1
Dermis
Psoriasis
Hyperplasia
Antibodies

Keywords

  • Adhesion molecules
  • Hyperproliferation
  • Neutrophil
  • Skin

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Pathology and Forensic Medicine
  • Clinical Biochemistry
  • Immunology and Allergy

Cite this

Chronic proliferative dermatitis in mice : Neutrophil-endothelium interactions and the role of adhesion molecules. / Gallardo Torres, H. I.; Gijbels, M. J J; HogenEsch, Harm; Kraal, G.

In: Pathobiology, Vol. 63, No. 6, 1995, p. 341-347.

Research output: Contribution to journalArticle

Gallardo Torres, H. I. ; Gijbels, M. J J ; HogenEsch, Harm ; Kraal, G. / Chronic proliferative dermatitis in mice : Neutrophil-endothelium interactions and the role of adhesion molecules. In: Pathobiology. 1995 ; Vol. 63, No. 6. pp. 341-347.
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