Cigarette smoking and pancreas cancer: A case - control study based on direct interviews

Debra T. Silverman, Janet A. Dunn, Robert N. Hoover, Mark Schiffiman, Keith D. Lillemoe, Janet B. Schoenberg, Linda M. Brown, Raymond S. Greenberg, Richard B. Hayes, G. Marie Swanson, Sholom Wacholder, Ann G. Schwartz, Jonathan M. Liff, Linda M. Pottern

Research output: Contribution to journalArticle

236 Citations (Scopus)

Abstract

Background:Cigarette smoking is the most consistently reported risk factor for pancreas cancer, yet the dose-response relationship in many pancreas cancer studies is weak. Because of the poor prognosis for pancreas cancer, many case-control studies have been based largely on interviews with proxy respondents, who are known to report less reliable information on detailed smoking habits than original subjects. Purpose: Our purpose was to evaluate cigarette smoking as a risk factor for pancreas cancer based on data obtained only from direct interviews and to estimate the effects of quitting smoking and of switching from nonfiltered to filtered cigarettes on risk. Our objective also was to estimate the contribution of cigarette smoking toward explaining the higher pancreas cancer incidence experienced by black Americans compared with white Americans. Methods: A population-based, case-control study of pancreas cancer was conducted during 1986-1989 in Atlanta, Ga., Detroit, Mich., and 10 counties in New Jersey. Direct interviews were successfully completed with 526 case patients and 2153 control subjects aged 30-79 years, making this the largest population-based, case-control study of pancreas cancer to date based only on direct interviews. Results: Cigarette smokers had a significant, 70% increased risk of pancreas cancer compared with the risk in non smokers. A significant, positive trend in risk with increasing duration smoked was apparent (P

Original languageEnglish (US)
Pages (from-to)1510-1516
Number of pages7
JournalJournal of the National Cancer Institute
Volume86
Issue number20
DOIs
StatePublished - Oct 19 1994
Externally publishedYes

Fingerprint

Case-control Study
Smoking
Pancreatic Neoplasms
Case-Control Studies
Cancer
Interviews
Risk Factors
Tobacco Products
Dose-response
Cigarette smoking
Prognosis
Proxy
Estimate
Population
Habits
Incidence
Evaluate

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Radiology Nuclear Medicine and imaging
  • Oncology
  • Cancer Research

Cite this

Silverman, D. T., Dunn, J. A., Hoover, R. N., Schiffiman, M., Lillemoe, K. D., Schoenberg, J. B., ... Pottern, L. M. (1994). Cigarette smoking and pancreas cancer: A case - control study based on direct interviews. Journal of the National Cancer Institute, 86(20), 1510-1516. https://doi.org/10.1093/jnci/86.20.1510

Cigarette smoking and pancreas cancer : A case - control study based on direct interviews. / Silverman, Debra T.; Dunn, Janet A.; Hoover, Robert N.; Schiffiman, Mark; Lillemoe, Keith D.; Schoenberg, Janet B.; Brown, Linda M.; Greenberg, Raymond S.; Hayes, Richard B.; Swanson, G. Marie; Wacholder, Sholom; Schwartz, Ann G.; Liff, Jonathan M.; Pottern, Linda M.

In: Journal of the National Cancer Institute, Vol. 86, No. 20, 19.10.1994, p. 1510-1516.

Research output: Contribution to journalArticle

Silverman, DT, Dunn, JA, Hoover, RN, Schiffiman, M, Lillemoe, KD, Schoenberg, JB, Brown, LM, Greenberg, RS, Hayes, RB, Swanson, GM, Wacholder, S, Schwartz, AG, Liff, JM & Pottern, LM 1994, 'Cigarette smoking and pancreas cancer: A case - control study based on direct interviews', Journal of the National Cancer Institute, vol. 86, no. 20, pp. 1510-1516. https://doi.org/10.1093/jnci/86.20.1510
Silverman DT, Dunn JA, Hoover RN, Schiffiman M, Lillemoe KD, Schoenberg JB et al. Cigarette smoking and pancreas cancer: A case - control study based on direct interviews. Journal of the National Cancer Institute. 1994 Oct 19;86(20):1510-1516. https://doi.org/10.1093/jnci/86.20.1510
Silverman, Debra T. ; Dunn, Janet A. ; Hoover, Robert N. ; Schiffiman, Mark ; Lillemoe, Keith D. ; Schoenberg, Janet B. ; Brown, Linda M. ; Greenberg, Raymond S. ; Hayes, Richard B. ; Swanson, G. Marie ; Wacholder, Sholom ; Schwartz, Ann G. ; Liff, Jonathan M. ; Pottern, Linda M. / Cigarette smoking and pancreas cancer : A case - control study based on direct interviews. In: Journal of the National Cancer Institute. 1994 ; Vol. 86, No. 20. pp. 1510-1516.
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