Cinacalcet, fibroblast growth factor-23, and cardiovascular disease in hemodialysis: The evaluation of cinacalcet HCl therapy to lower cardiovascular events (EVOLVE) trial

Sharon Moe, Glenn M. Chertow, Patrick S. Parfrey, Yumi Kubo, Geoffrey A. Block, Ricardo Correa-Rotter, Tilman B. Drüeke, Charles A. Herzog, Gerard M. London, Kenneth W. Mahaffey, David C. Wheeler, Maria Stolina, Bastian Dehmel, William G. Goodman, Jürgen Floege, J. Santos, C. Najun Zarazaga, I. Marin, N. Garrote, A. CusumanoN. Peñalba, E. Del Valle, L. Juncos, J. Martinez Saye, L. Lef, V. Altobelli, G. Petraglia, G. Rosa Diez, W. Douthat, J. Lobo, C. Gallart, A. Lafalla, G. Diez, B. Linares, N. Lopez, N. Ramirez, R. Gonzalez, R. Valtuille, H. Beresan, O. Hermida, G. Rudolf, N. Marchetta, M. Rano, M. Ramirez, N. García, A. Gillies, B. Jones, E. Pedagogos, R. Walker, G. Talaulikar, K. Bannister, M. Suranyi, A. Kark, S. Roger, P. Kerr, A. Disney, P. Mount, M. Fraenkel, M. Mathew, R. Fassett, M. Jose, C. Hawley, M. Lonergan, J. Mackie, P. Ferrari, S. Menahem, J. Sabto, B. Hutchison, R. Langham, C. Pollock, H. Holzer, R. Oberbauer, I. Arias, H. Graf, G. Mayer, K. Lhotta, U. Neyer, R. Klauser, W. Hoerl, S. Horn, J. Kovarik, R. Kramar, M. Eigner, M. Dhaene, J. Billiouw, J. De Meester, X. Warling, P. Cambier-Dwelschauwers, P. Evenepoel, R. Daelemans, M. Dratwa, B. Maes, J. Stolear, T. Dejagere, J. Vanwalleghem, K. Bouman, M. Jadoul, J. Peeters, R. Vanholder, C. Tielemans, J. Donck, F. Almeida, J. Picollo De Oliveira, E. Burdmann, V. Garcia, F. Saldanha Thome, L. Deboni, R. Bregman, J. Lugon, S. Araújo, S. Ferreira Filho, E. De Francesco Daher, M. Sperto Baptista, A. Carvalho, D. D'Avila, M. Moyses Neto, L. Yu, M. Bastos, P. Sampaio Lacativa, V. Jorgetti, E. De Almeida Romão, J. Cardeal Da Costa, R. Pecoits Filho, P. Gordan, N. Salgado, M. Teixeira Araújo, S. Neiva Coelho, I. Oliveira, R. Moysés, L. Vasconcellos, P. Batista, J. Luiz Gross, A. Pedrosa, S. Cournoyer, M. LeBlanc, S. Chow, S. Karunakaran, G. Wong, S. Tobe, S. Desmeules, D. Zimmerman, S. Murphy, P. Montambault, S. Donnelly, J. MacRae, B. Culleton, S. Soroka, C. Rabbat, K. Jindal, M. Vasilevsky, M. Michaud, E. Wijeyesinghe, J. Zacharias, C. Lok, N. Muirhead, M. Verrelli, G. Da Roza, D. Sapir, K. Olgaard, H. Daugaard, L. Brandi, P. Jensen, H. Boulechfar, K. Ang, P. Simon, P. Rieu, P. Brunet, G. Touchard, P. Urena Torres, C. Combe, A. Durrbach, J. Ortiz, T. Hannedouche, C. Vela, A. Lionet, P. Ryckelynck, P. Zaoui, G. Choukroun, H. Fessi, P. Lang, P. Stroumza, D. Joly, C. Mousson, M. Laville, F. Dellanna, C. Erley, J. Braun, M. Rambausek, W. Riegel, M. Klingberg, E. Schwertfeger, V. Wizemann, K. Eckardt, H. Reichel, J. Passauer, E. Hübel, N. Frischmuth, R. Liebl, R. Fiedler, V. Schwenger, A. Voßkühler, U. Kunzendorf, L. Renders, D. Rattensberger, L. Rump, M. Ketteler, H. Neumayer, F. Zantvoort, R. Stahl, E. Ladanyi, I. Kulcsar, I. Mezei, B. Csiky, C. Rikker, O. Arkossy, K. Berta, J. Szegedi, L. Major, S. Ferenczi, A. Fekete, T. Szabo, G. Zakar, G. Wagner, S. Kazup Erdelyine, B. Borbas, J. Eustace, D. Reddan, G. Capasso, F. Locatelli, G. Villa, M. Cozzolino, D. Brancaccio, P. Messa, P. Bolasco, B. Ricciardi, F. Malberti, E. Moriero, G. Cannella, V. Ortalda, S. Stefoni, G. Frascà, G. Cappelli, A. Albertazzi, C. Zoccali, M. Farina, A. Elli, F. Avella, P. Ondei, G. Mingardi, R. Errico, A. Losito, S. Di Giulio, G. Pertosa, F. Schena, G. Grandaliano, L. Gesualdo, M. Auricchio, T. Bochicchio-Ricardelli, F. Aranda Verástegui, J. Peña, A. Chew Wong, J. Cruz-Valdez, M. Torres Zamora, M. Solis, M. Sebastian Diaz, M. Vital Flores, E. Alvarez Sandoval, M. Van Den Dorpel, H. Brink, W. Van Kuijk, C. Vermeij, P. Smak Gregoor, E. Hagen, F. Van Der Sande, M. Klinger, M. Nowicki, M. Muszytowski, K. Bidas, W. Bentkowski, A. Wiecek, A. Ksiazek, K. Marczewski, M. Ostrowski, M. Switalski, W. Sulowicz, J. Matuszkiewicz-Rowinska, M. Mysliwiec, M. Durlik, B. Rutkowski, F. Macario, B. Carvalho, J. Frazao, D. Machado, A. Weigert, A. Andrusev, O. Khrustalev, A. Zemtchenkov, K. Gurevich, K. Staroselsky, N. Khadikova, L. Rozhinskaya, G. Timokhovskaya, A. Strokov, O. Balkarova, V. Ermolenko, E. Kolmakova, M. Komandenko, M. Timofeev, V. Shilo, G. Shostka, A. Smirnov, V. Anashkin, G. Volgina, O. Domashenko, A. Gurevich, D. Perlin, J. Martínez García, E. Andrés Ribes, E. Coll Piera, M. Fernandez Lucas, M. Galicia, M. Prados, M. González, R. Romero, De Francisco Martín De Francisco, J. Montenegro, C. Santiago, F. García, J. Alcázar De La Ossa, J. Arrieta, J. Pons, A. Martín-Malo, J. Soler Amigó, A. Cases, G. Sterner, G. Jensen, B. Wikström, S. Jacobson, U. Lund, L. Weiss, A. Ståhl, B. Von Albertini, M. Burnier, P. Meier, P. Martin, D. Uehlinger, M. Dickenmann, M. Yaqoob, D. Zehnder, P. Kalra, N. Padmanabhan, S. Roe, D. Eadington, N. Pritchard, A. Hutchison, S. Davies, M. Wilkie, M. Davies, P. Pai, P. Swift, J. Kwan, D. Goldsmith, C. Tomson, J. Stratton, I. Dasgupta, S. Sarkar, M. Moustafa, K. Gandhi, A. Jamal, E. Galindo-Ramos, J. Tuazon, D. Batlle, K. Tucker, B. Schiller-Moran, A. Assefi, C. Martinez, L. Samuels, J. Goldman, J. Cangiano-Rivera, R. Darwish, M. Lee, J. Topf, K. Kapatkin, H. Baer, R. Kopelman, M. Acharya, D. Tharpe, M. Bernardo, P. Nader, J. Guzman-Rivera, P. Pergola, M. Sekkarie, E. Alas, P. Zager, K. Liss, J. Navarro, M. Roppolo, C. Denu-Ciocca, A. Kshirsagar, M. El Khatib, K. Kant, D. Scott, B. Murthyr, F. Finkelstein, G. Keightley, R. McCrary, J. Pitone, T. Cavalieri, A. Tsang, B. Pellegrino, R. Schmidt, S. Ahmad, C. Brown, E. Friedman, N. Mittman, S. Fadem, W. Shapiro, M. Reddy, S. Goldberger, Y. Woredekal, A. Agarwal, M. Anger, M. Haque, P. Chidester, R. Kohli, S. Rubinstein, G. Newman, R. Gladish, O. Ayodeji, S. Soman, S. Sprague, N. Hunt, T. Gehr, D. Rizk, D. Warnock, D. Polack, M. Pahl, D. Fischer, P. Dreyer, G. James, F. Husserl, T. Rogers, A. Raff, J. Sedor, M. Silver, M. Smith, S. Steinberg, T. DelGiorno, E. Jones, P. D Cunha, J. Cheng, V. Pogue, S. Blumenthal, E. Brown, C. Charytan, J. Buerkert, M. Cook, A. Felsenfeld, N. Tareen, A. Gupta, T. Herman, S. Diamond, C. Hura, M. Laski, J. MacLaurin, T. Plumb, G. Brosnahan, J. Kumar, M. Henriquez, C. Poole, E. Osanloo, A. Matalon, C. Sholer, S. Arfeen, M. Azer, M. Belledonne, M. Gross, E. Dunnigan, K. McConnell, B. Becker, F. Skinner, R. Rigolosi, D. Spiegel, M. Stegman, R. Patak, D. Streja, U. Ranjit, T. Youell, T. Wooldridge, C. Stafford, R. Cottiero, M. Weinberg, M. Schonefeld, E. Shahmir, A. Hazzan, A. Ashfaq, K. Bhandari, W. Cleveland, M. Culpepper, J. Golden, L. Lai, Y. Lien, V. Lorica, J. Robertson, K. Malireddi, S. Morse, V. Thakur, A. Israelit, P. Raguram, H. Alfred, W. Weise, F. Al-Saghir, M. El Shahawy, A. Rastogi, A. Nissenson, N. Kopyt, R. Lynn, J. Lea, W. McClellan, P. Teredesai, S. Ong, S. Tolkan, J. Sugihara, T. Minga, R. Mehrotra, R. Minasian, D. Bhatia, R. Specter, J. Capelli, P. Sidhu, S. Dalal, P. Dykes, M. Khan, F. Rahim, M. Saklayen, A. Thomas, B. Michael, M. Torres, H. Al-Bander, B. Murray, A. Abukurah, B. Gupta, S. Nosrati, R. Raja, S. Zeig, M. Braun, A. Amatya, J. Endsley, Z. Sharon, A. Gupta, G. Dolson, F. Dumler, K. Ntoso, S. Rosansky, N. Kumar, V. Gura, N. Thompson, D. Goldfarb, R. Halligan, J. Middleton, A. Widerhorn, L. Arbeit, J. Arruda, T. Crouch, L. Friedman, S. Khokhar, J. Mittleman, P. Light, B. Taparia, C. West, J. Cotton, R. Dhingra, L. Kleinman, F. Arif, S. Lew, T. Nammour, J. Sterrett, M. Williams, J. Ramirez, J. Rubin, J. McCarthy, S. Noble, M. Chaffin, A. Rekhi

Research output: Contribution to journalArticle

135 Citations (Scopus)

Abstract

Background-Patients with kidney disease have disordered bone and mineral metabolism, including elevated serum concentrations of fibroblast growth factor-23 (FGF23). These elevated concentrations are associated with cardiovascular and all-cause mortality. The objective was to determine the effects of the calcimimetic cinacalcet (versus placebo) on reducing serum FGF23 and whether changes in FGF23 are associated with death and cardiovascular events. Methods and Results-This was a secondary analysis of a randomized clinical trial comparing cinacalcet to placebo in addition to conventional therapy (phosphate binders/vitamin D) in patients receiving hemodialysis with secondary hyperparathyroidism (intact parathyroid hormone ≥300 pg/mL). The primary study end point was time to death or a first nonfatal cardiovascular event (myocardial infarction, hospitalization for angina, heart failure, or a peripheral vascular event). This analysis included 2985 patients (77% of randomized) with serum samples at baseline and 2602 patients (67%) with samples at both baseline and week 20. The results demonstrated that a significantly larger proportion of patients randomized to cinacalcet had ≥30% (68% versus 28%) reductions in FGF23. Among patients randomized to cinacalcet, a ≥30% reduction in FGF23 between baseline and week 20 was associated with a nominally significant reduction in the primary composite end point (relative hazard, 0.82; 95% confidence interval, 0.69-0.98), cardiovascular mortality (relative hazard, 0.66; 95% confidence interval, 0.50-0.87), sudden cardiac death (relative hazard, 0.57; 95% confidence interval, 0.37-0.86), and heart failure (relative hazard, 0.69; 95% confidence interval, 0.48-0.99). Conclusions-Treatment with cinacalcet significantly lowers serum FGF23. Treatment-induced reductions in serum FGF23 are associated with lower rates of cardiovascular death and major cardiovascular events.

Original languageEnglish
Pages (from-to)27-39
Number of pages13
JournalCirculation
Volume132
Issue number1
DOIs
StatePublished - 2015

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Renal Dialysis
Cardiovascular Diseases
Confidence Intervals
Serum
Therapeutics
Mortality
Heart Failure
Placebos
Secondary Hyperparathyroidism
Sudden Cardiac Death
Kidney Diseases
fibroblast growth factor 23
Cinacalcet Hydrochloride
Parathyroid Hormone
Vitamin D
Minerals
Blood Vessels
Hospitalization
Randomized Controlled Trials
Phosphates

Keywords

  • Arrhythmias
  • Calcium
  • Cardiac
  • Cardiac
  • Chronic
  • Death
  • Renal insufficiency
  • Sudden
  • Ventricular remodeling

ASJC Scopus subject areas

  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

Cinacalcet, fibroblast growth factor-23, and cardiovascular disease in hemodialysis : The evaluation of cinacalcet HCl therapy to lower cardiovascular events (EVOLVE) trial. / Moe, Sharon; Chertow, Glenn M.; Parfrey, Patrick S.; Kubo, Yumi; Block, Geoffrey A.; Correa-Rotter, Ricardo; Drüeke, Tilman B.; Herzog, Charles A.; London, Gerard M.; Mahaffey, Kenneth W.; Wheeler, David C.; Stolina, Maria; Dehmel, Bastian; Goodman, William G.; Floege, Jürgen; Santos, J.; Najun Zarazaga, C.; Marin, I.; Garrote, N.; Cusumano, A.; Peñalba, N.; Del Valle, E.; Juncos, L.; Martinez Saye, J.; Lef, L.; Altobelli, V.; Petraglia, G.; Rosa Diez, G.; Douthat, W.; Lobo, J.; Gallart, C.; Lafalla, A.; Diez, G.; Linares, B.; Lopez, N.; Ramirez, N.; Gonzalez, R.; Valtuille, R.; Beresan, H.; Hermida, O.; Rudolf, G.; Marchetta, N.; Rano, M.; Ramirez, M.; García, N.; Gillies, A.; Jones, B.; Pedagogos, E.; Walker, R.; Talaulikar, G.; Bannister, K.; Suranyi, M.; Kark, A.; Roger, S.; Kerr, P.; Disney, A.; Mount, P.; Fraenkel, M.; Mathew, M.; Fassett, R.; Jose, M.; Hawley, C.; Lonergan, M.; Mackie, J.; Ferrari, P.; Menahem, S.; Sabto, J.; Hutchison, B.; Langham, R.; Pollock, C.; Holzer, H.; Oberbauer, R.; Arias, I.; Graf, H.; Mayer, G.; Lhotta, K.; Neyer, U.; Klauser, R.; Hoerl, W.; Horn, S.; Kovarik, J.; Kramar, R.; Eigner, M.; Dhaene, M.; Billiouw, J.; De Meester, J.; Warling, X.; Cambier-Dwelschauwers, P.; Evenepoel, P.; Daelemans, R.; Dratwa, M.; Maes, B.; Stolear, J.; Dejagere, T.; Vanwalleghem, J.; Bouman, K.; Jadoul, M.; Peeters, J.; Vanholder, R.; Tielemans, C.; Donck, J.; Almeida, F.; Picollo De Oliveira, J.; Burdmann, E.; Garcia, V.; Saldanha Thome, F.; Deboni, L.; Bregman, R.; Lugon, J.; Araújo, S.; Ferreira Filho, S.; De Francesco Daher, E.; Sperto Baptista, M.; Carvalho, A.; D'Avila, D.; Moyses Neto, M.; Yu, L.; Bastos, M.; Sampaio Lacativa, P.; Jorgetti, V.; De Almeida Romão, E.; Cardeal Da Costa, J.; Pecoits Filho, R.; Gordan, P.; Salgado, N.; Teixeira Araújo, M.; Neiva Coelho, S.; Oliveira, I.; Moysés, R.; Vasconcellos, L.; Batista, P.; Luiz Gross, J.; Pedrosa, A.; Cournoyer, S.; LeBlanc, M.; Chow, S.; Karunakaran, S.; Wong, G.; Tobe, S.; Desmeules, S.; Zimmerman, D.; Murphy, S.; Montambault, P.; Donnelly, S.; MacRae, J.; Culleton, B.; Soroka, S.; Rabbat, C.; Jindal, K.; Vasilevsky, M.; Michaud, M.; Wijeyesinghe, E.; Zacharias, J.; Lok, C.; Muirhead, N.; Verrelli, M.; Da Roza, G.; Sapir, D.; Olgaard, K.; Daugaard, H.; Brandi, L.; Jensen, P.; Boulechfar, H.; Ang, K.; Simon, P.; Rieu, P.; Brunet, P.; Touchard, G.; Urena Torres, P.; Combe, C.; Durrbach, A.; Ortiz, J.; Hannedouche, T.; Vela, C.; Lionet, A.; Ryckelynck, P.; Zaoui, P.; Choukroun, G.; Fessi, H.; Lang, P.; Stroumza, P.; Joly, D.; Mousson, C.; Laville, M.; Dellanna, F.; Erley, C.; Braun, J.; Rambausek, M.; Riegel, W.; Klingberg, M.; Schwertfeger, E.; Wizemann, V.; Eckardt, K.; Reichel, H.; Passauer, J.; Hübel, E.; Frischmuth, N.; Liebl, R.; Fiedler, R.; Schwenger, V.; Voßkühler, A.; Kunzendorf, U.; Renders, L.; Rattensberger, D.; Rump, L.; Ketteler, M.; Neumayer, H.; Zantvoort, F.; Stahl, R.; Ladanyi, E.; Kulcsar, I.; Mezei, I.; Csiky, B.; Rikker, C.; Arkossy, O.; Berta, K.; Szegedi, J.; Major, L.; Ferenczi, S.; Fekete, A.; Szabo, T.; Zakar, G.; Wagner, G.; Kazup Erdelyine, S.; Borbas, B.; Eustace, J.; Reddan, D.; Capasso, G.; Locatelli, F.; Villa, G.; Cozzolino, M.; Brancaccio, D.; Messa, P.; Bolasco, P.; Ricciardi, B.; Malberti, F.; Moriero, E.; Cannella, G.; Ortalda, V.; Stefoni, S.; Frascà, G.; Cappelli, G.; Albertazzi, A.; Zoccali, C.; Farina, M.; Elli, A.; Avella, F.; Ondei, P.; Mingardi, G.; Errico, R.; Losito, A.; Di Giulio, S.; Pertosa, G.; Schena, F.; Grandaliano, G.; Gesualdo, L.; Auricchio, M.; Bochicchio-Ricardelli, T.; Aranda Verástegui, F.; Peña, J.; Chew Wong, A.; Cruz-Valdez, J.; Torres Zamora, M.; Solis, M.; Sebastian Diaz, M.; Vital Flores, M.; Alvarez Sandoval, E.; Van Den Dorpel, M.; Brink, H.; Van Kuijk, W.; Vermeij, C.; Smak Gregoor, P.; Hagen, E.; Van Der Sande, F.; Klinger, M.; Nowicki, M.; Muszytowski, M.; Bidas, K.; Bentkowski, W.; Wiecek, A.; Ksiazek, A.; Marczewski, K.; Ostrowski, M.; Switalski, M.; Sulowicz, W.; Matuszkiewicz-Rowinska, J.; Mysliwiec, M.; Durlik, M.; Rutkowski, B.; Macario, F.; Carvalho, B.; Frazao, J.; Machado, D.; Weigert, A.; Andrusev, A.; Khrustalev, O.; Zemtchenkov, A.; Gurevich, K.; Staroselsky, K.; Khadikova, N.; Rozhinskaya, L.; Timokhovskaya, G.; Strokov, A.; Balkarova, O.; Ermolenko, V.; Kolmakova, E.; Komandenko, M.; Timofeev, M.; Shilo, V.; Shostka, G.; Smirnov, A.; Anashkin, V.; Volgina, G.; Domashenko, O.; Gurevich, A.; Perlin, D.; Martínez García, J.; Andrés Ribes, E.; Coll Piera, E.; Fernandez Lucas, M.; Galicia, M.; Prados, M.; González, M.; Romero, R.; Martín De Francisco, De Francisco; Montenegro, J.; Santiago, C.; García, F.; Alcázar De La Ossa, J.; Arrieta, J.; Pons, J.; Martín-Malo, A.; Soler Amigó, J.; Cases, A.; Sterner, G.; Jensen, G.; Wikström, B.; Jacobson, S.; Lund, U.; Weiss, L.; Ståhl, A.; Von Albertini, B.; Burnier, M.; Meier, P.; Martin, P.; Uehlinger, D.; Dickenmann, M.; Yaqoob, M.; Zehnder, D.; Kalra, P.; Padmanabhan, N.; Roe, S.; Eadington, D.; Pritchard, N.; Hutchison, A.; Davies, S.; Wilkie, M.; Davies, M.; Pai, P.; Swift, P.; Kwan, J.; Goldsmith, D.; Tomson, C.; Stratton, J.; Dasgupta, I.; Sarkar, S.; Moustafa, M.; Gandhi, K.; Jamal, A.; Galindo-Ramos, E.; Tuazon, J.; Batlle, D.; Tucker, K.; Schiller-Moran, B.; Assefi, A.; Martinez, C.; Samuels, L.; Goldman, J.; Cangiano-Rivera, J.; Darwish, R.; Lee, M.; Topf, J.; Kapatkin, K.; Baer, H.; Kopelman, R.; Acharya, M.; Tharpe, D.; Bernardo, M.; Nader, P.; Guzman-Rivera, J.; Pergola, P.; Sekkarie, M.; Alas, E.; Zager, P.; Liss, K.; Navarro, J.; Roppolo, M.; Denu-Ciocca, C.; Kshirsagar, A.; El Khatib, M.; Kant, K.; Scott, D.; Murthyr, B.; Finkelstein, F.; Keightley, G.; McCrary, R.; Pitone, J.; Cavalieri, T.; Tsang, A.; Pellegrino, B.; Schmidt, R.; Ahmad, S.; Brown, C.; Friedman, E.; Mittman, N.; Fadem, S.; Shapiro, W.; Reddy, M.; Goldberger, S.; Woredekal, Y.; Agarwal, A.; Anger, M.; Haque, M.; Chidester, P.; Kohli, R.; Rubinstein, S.; Newman, G.; Gladish, R.; Ayodeji, O.; Soman, S.; Sprague, S.; Hunt, N.; Gehr, T.; Rizk, D.; Warnock, D.; Polack, D.; Pahl, M.; Fischer, D.; Dreyer, P.; James, G.; Husserl, F.; Rogers, T.; Raff, A.; Sedor, J.; Silver, M.; Smith, M.; Steinberg, S.; DelGiorno, T.; Jones, E.; D Cunha, P.; Cheng, J.; Pogue, V.; Blumenthal, S.; Brown, E.; Charytan, C.; Buerkert, J.; Cook, M.; Felsenfeld, A.; Tareen, N.; Gupta, A.; Herman, T.; Diamond, S.; Hura, C.; Laski, M.; MacLaurin, J.; Plumb, T.; Brosnahan, G.; Kumar, J.; Henriquez, M.; Poole, C.; Osanloo, E.; Matalon, A.; Sholer, C.; Arfeen, S.; Azer, M.; Belledonne, M.; Gross, M.; Dunnigan, E.; McConnell, K.; Becker, B.; Skinner, F.; Rigolosi, R.; Spiegel, D.; Stegman, M.; Patak, R.; Streja, D.; Ranjit, U.; Youell, T.; Wooldridge, T.; Stafford, C.; Cottiero, R.; Weinberg, M.; Schonefeld, M.; Shahmir, E.; Hazzan, A.; Ashfaq, A.; Bhandari, K.; Cleveland, W.; Culpepper, M.; Golden, J.; Lai, L.; Lien, Y.; Lorica, V.; Robertson, J.; Malireddi, K.; Morse, S.; Thakur, V.; Israelit, A.; Raguram, P.; Alfred, H.; Weise, W.; Al-Saghir, F.; El Shahawy, M.; Rastogi, A.; Nissenson, A.; Kopyt, N.; Lynn, R.; Lea, J.; McClellan, W.; Teredesai, P.; Ong, S.; Tolkan, S.; Sugihara, J.; Minga, T.; Mehrotra, R.; Minasian, R.; Bhatia, D.; Specter, R.; Capelli, J.; Sidhu, P.; Dalal, S.; Dykes, P.; Khan, M.; Rahim, F.; Saklayen, M.; Thomas, A.; Michael, B.; Torres, M.; Al-Bander, H.; Murray, B.; Abukurah, A.; Gupta, B.; Nosrati, S.; Raja, R.; Zeig, S.; Braun, M.; Amatya, A.; Endsley, J.; Sharon, Z.; Gupta, A.; Dolson, G.; Dumler, F.; Ntoso, K.; Rosansky, S.; Kumar, N.; Gura, V.; Thompson, N.; Goldfarb, D.; Halligan, R.; Middleton, J.; Widerhorn, A.; Arbeit, L.; Arruda, J.; Crouch, T.; Friedman, L.; Khokhar, S.; Mittleman, J.; Light, P.; Taparia, B.; West, C.; Cotton, J.; Dhingra, R.; Kleinman, L.; Arif, F.; Lew, S.; Nammour, T.; Sterrett, J.; Williams, M.; Ramirez, J.; Rubin, J.; McCarthy, J.; Noble, S.; Chaffin, M.; Rekhi, A.

In: Circulation, Vol. 132, No. 1, 2015, p. 27-39.

Research output: Contribution to journalArticle

Moe, S, Chertow, GM, Parfrey, PS, Kubo, Y, Block, GA, Correa-Rotter, R, Drüeke, TB, Herzog, CA, London, GM, Mahaffey, KW, Wheeler, DC, Stolina, M, Dehmel, B, Goodman, WG, Floege, J, Santos, J, Najun Zarazaga, C, Marin, I, Garrote, N, Cusumano, A, Peñalba, N, Del Valle, E, Juncos, L, Martinez Saye, J, Lef, L, Altobelli, V, Petraglia, G, Rosa Diez, G, Douthat, W, Lobo, J, Gallart, C, Lafalla, A, Diez, G, Linares, B, Lopez, N, Ramirez, N, Gonzalez, R, Valtuille, R, Beresan, H, Hermida, O, Rudolf, G, Marchetta, N, Rano, M, Ramirez, M, García, N, Gillies, A, Jones, B, Pedagogos, E, Walker, R, Talaulikar, G, Bannister, K, Suranyi, M, Kark, A, Roger, S, Kerr, P, Disney, A, Mount, P, Fraenkel, M, Mathew, M, Fassett, R, Jose, M, Hawley, C, Lonergan, M, Mackie, J, Ferrari, P, Menahem, S, Sabto, J, Hutchison, B, Langham, R, Pollock, C, Holzer, H, Oberbauer, R, Arias, I, Graf, H, Mayer, G, Lhotta, K, Neyer, U, Klauser, R, Hoerl, W, Horn, S, Kovarik, J, Kramar, R, Eigner, M, Dhaene, M, Billiouw, J, De Meester, J, Warling, X, Cambier-Dwelschauwers, P, Evenepoel, P, Daelemans, R, Dratwa, M, Maes, B, Stolear, J, Dejagere, T, Vanwalleghem, J, Bouman, K, Jadoul, M, Peeters, J, Vanholder, R, Tielemans, C, Donck, J, Almeida, F, Picollo De Oliveira, J, Burdmann, E, Garcia, V, Saldanha Thome, F, Deboni, L, Bregman, R, Lugon, J, Araújo, S, Ferreira Filho, S, De Francesco Daher, E, Sperto Baptista, M, Carvalho, A, D'Avila, D, Moyses Neto, M, Yu, L, Bastos, M, Sampaio Lacativa, P, Jorgetti, V, De Almeida Romão, E, Cardeal Da Costa, J, Pecoits Filho, R, Gordan, P, Salgado, N, Teixeira Araújo, M, Neiva Coelho, S, Oliveira, I, Moysés, R, Vasconcellos, L, Batista, P, Luiz Gross, J, Pedrosa, A, Cournoyer, S, LeBlanc, M, Chow, S, Karunakaran, S, Wong, G, Tobe, S, Desmeules, S, Zimmerman, D, Murphy, S, Montambault, P, Donnelly, S, MacRae, J, Culleton, B, Soroka, S, Rabbat, C, Jindal, K, Vasilevsky, M, Michaud, M, Wijeyesinghe, E, Zacharias, J, Lok, C, Muirhead, N, Verrelli, M, Da Roza, G, Sapir, D, Olgaard, K, Daugaard, H, Brandi, L, Jensen, P, Boulechfar, H, Ang, K, Simon, P, Rieu, P, Brunet, P, Touchard, G, Urena Torres, P, Combe, C, Durrbach, A, Ortiz, J, Hannedouche, T, Vela, C, Lionet, A, Ryckelynck, P, Zaoui, P, Choukroun, G, Fessi, H, Lang, P, Stroumza, P, Joly, D, Mousson, C, Laville, M, Dellanna, F, Erley, C, Braun, J, Rambausek, M, Riegel, W, Klingberg, M, Schwertfeger, E, Wizemann, V, Eckardt, K, Reichel, H, Passauer, J, Hübel, E, Frischmuth, N, Liebl, R, Fiedler, R, Schwenger, V, Voßkühler, A, Kunzendorf, U, Renders, L, Rattensberger, D, Rump, L, Ketteler, M, Neumayer, H, Zantvoort, F, Stahl, R, Ladanyi, E, Kulcsar, I, Mezei, I, Csiky, B, Rikker, C, Arkossy, O, Berta, K, Szegedi, J, Major, L, Ferenczi, S, Fekete, A, Szabo, T, Zakar, G, Wagner, G, Kazup Erdelyine, S, Borbas, B, Eustace, J, Reddan, D, Capasso, G, Locatelli, F, Villa, G, Cozzolino, M, Brancaccio, D, Messa, P, Bolasco, P, Ricciardi, B, Malberti, F, Moriero, E, Cannella, G, Ortalda, V, Stefoni, S, Frascà, G, Cappelli, G, Albertazzi, A, Zoccali, C, Farina, M, Elli, A, Avella, F, Ondei, P, Mingardi, G, Errico, R, Losito, A, Di Giulio, S, Pertosa, G, Schena, F, Grandaliano, G, Gesualdo, L, Auricchio, M, Bochicchio-Ricardelli, T, Aranda Verástegui, F, Peña, J, Chew Wong, A, Cruz-Valdez, J, Torres Zamora, M, Solis, M, Sebastian Diaz, M, Vital Flores, M, Alvarez Sandoval, E, Van Den Dorpel, M, Brink, H, Van Kuijk, W, Vermeij, C, Smak Gregoor, P, Hagen, E, Van Der Sande, F, Klinger, M, Nowicki, M, Muszytowski, M, Bidas, K, Bentkowski, W, Wiecek, A, Ksiazek, A, Marczewski, K, Ostrowski, M, Switalski, M, Sulowicz, W, Matuszkiewicz-Rowinska, J, Mysliwiec, M, Durlik, M, Rutkowski, B, Macario, F, Carvalho, B, Frazao, J, Machado, D, Weigert, A, Andrusev, A, Khrustalev, O, Zemtchenkov, A, Gurevich, K, Staroselsky, K, Khadikova, N, Rozhinskaya, L, Timokhovskaya, G, Strokov, A, Balkarova, O, Ermolenko, V, Kolmakova, E, Komandenko, M, Timofeev, M, Shilo, V, Shostka, G, Smirnov, A, Anashkin, V, Volgina, G, Domashenko, O, Gurevich, A, Perlin, D, Martínez García, J, Andrés Ribes, E, Coll Piera, E, Fernandez Lucas, M, Galicia, M, Prados, M, González, M, Romero, R, Martín De Francisco, DF, Montenegro, J, Santiago, C, García, F, Alcázar De La Ossa, J, Arrieta, J, Pons, J, Martín-Malo, A, Soler Amigó, J, Cases, A, Sterner, G, Jensen, G, Wikström, B, Jacobson, S, Lund, U, Weiss, L, Ståhl, A, Von Albertini, B, Burnier, M, Meier, P, Martin, P, Uehlinger, D, Dickenmann, M, Yaqoob, M, Zehnder, D, Kalra, P, Padmanabhan, N, Roe, S, Eadington, D, Pritchard, N, Hutchison, A, Davies, S, Wilkie, M, Davies, M, Pai, P, Swift, P, Kwan, J, Goldsmith, D, Tomson, C, Stratton, J, Dasgupta, I, Sarkar, S, Moustafa, M, Gandhi, K, Jamal, A, Galindo-Ramos, E, Tuazon, J, Batlle, D, Tucker, K, Schiller-Moran, B, Assefi, A, Martinez, C, Samuels, L, Goldman, J, Cangiano-Rivera, J, Darwish, R, Lee, M, Topf, J, Kapatkin, K, Baer, H, Kopelman, R, Acharya, M, Tharpe, D, Bernardo, M, Nader, P, Guzman-Rivera, J, Pergola, P, Sekkarie, M, Alas, E, Zager, P, Liss, K, Navarro, J, Roppolo, M, Denu-Ciocca, C, Kshirsagar, A, El Khatib, M, Kant, K, Scott, D, Murthyr, B, Finkelstein, F, Keightley, G, McCrary, R, Pitone, J, Cavalieri, T, Tsang, A, Pellegrino, B, Schmidt, R, Ahmad, S, Brown, C, Friedman, E, Mittman, N, Fadem, S, Shapiro, W, Reddy, M, Goldberger, S, Woredekal, Y, Agarwal, A, Anger, M, Haque, M, Chidester, P, Kohli, R, Rubinstein, S, Newman, G, Gladish, R, Ayodeji, O, Soman, S, Sprague, S, Hunt, N, Gehr, T, Rizk, D, Warnock, D, Polack, D, Pahl, M, Fischer, D, Dreyer, P, James, G, Husserl, F, Rogers, T, Raff, A, Sedor, J, Silver, M, Smith, M, Steinberg, S, DelGiorno, T, Jones, E, D Cunha, P, Cheng, J, Pogue, V, Blumenthal, S, Brown, E, Charytan, C, Buerkert, J, Cook, M, Felsenfeld, A, Tareen, N, Gupta, A, Herman, T, Diamond, S, Hura, C, Laski, M, MacLaurin, J, Plumb, T, Brosnahan, G, Kumar, J, Henriquez, M, Poole, C, Osanloo, E, Matalon, A, Sholer, C, Arfeen, S, Azer, M, Belledonne, M, Gross, M, Dunnigan, E, McConnell, K, Becker, B, Skinner, F, Rigolosi, R, Spiegel, D, Stegman, M, Patak, R, Streja, D, Ranjit, U, Youell, T, Wooldridge, T, Stafford, C, Cottiero, R, Weinberg, M, Schonefeld, M, Shahmir, E, Hazzan, A, Ashfaq, A, Bhandari, K, Cleveland, W, Culpepper, M, Golden, J, Lai, L, Lien, Y, Lorica, V, Robertson, J, Malireddi, K, Morse, S, Thakur, V, Israelit, A, Raguram, P, Alfred, H, Weise, W, Al-Saghir, F, El Shahawy, M, Rastogi, A, Nissenson, A, Kopyt, N, Lynn, R, Lea, J, McClellan, W, Teredesai, P, Ong, S, Tolkan, S, Sugihara, J, Minga, T, Mehrotra, R, Minasian, R, Bhatia, D, Specter, R, Capelli, J, Sidhu, P, Dalal, S, Dykes, P, Khan, M, Rahim, F, Saklayen, M, Thomas, A, Michael, B, Torres, M, Al-Bander, H, Murray, B, Abukurah, A, Gupta, B, Nosrati, S, Raja, R, Zeig, S, Braun, M, Amatya, A, Endsley, J, Sharon, Z, Gupta, A, Dolson, G, Dumler, F, Ntoso, K, Rosansky, S, Kumar, N, Gura, V, Thompson, N, Goldfarb, D, Halligan, R, Middleton, J, Widerhorn, A, Arbeit, L, Arruda, J, Crouch, T, Friedman, L, Khokhar, S, Mittleman, J, Light, P, Taparia, B, West, C, Cotton, J, Dhingra, R, Kleinman, L, Arif, F, Lew, S, Nammour, T, Sterrett, J, Williams, M, Ramirez, J, Rubin, J, McCarthy, J, Noble, S, Chaffin, M & Rekhi, A 2015, 'Cinacalcet, fibroblast growth factor-23, and cardiovascular disease in hemodialysis: The evaluation of cinacalcet HCl therapy to lower cardiovascular events (EVOLVE) trial', Circulation, vol. 132, no. 1, pp. 27-39. https://doi.org/10.1161/CIRCULATIONAHA.114.013876
Moe, Sharon ; Chertow, Glenn M. ; Parfrey, Patrick S. ; Kubo, Yumi ; Block, Geoffrey A. ; Correa-Rotter, Ricardo ; Drüeke, Tilman B. ; Herzog, Charles A. ; London, Gerard M. ; Mahaffey, Kenneth W. ; Wheeler, David C. ; Stolina, Maria ; Dehmel, Bastian ; Goodman, William G. ; Floege, Jürgen ; Santos, J. ; Najun Zarazaga, C. ; Marin, I. ; Garrote, N. ; Cusumano, A. ; Peñalba, N. ; Del Valle, E. ; Juncos, L. ; Martinez Saye, J. ; Lef, L. ; Altobelli, V. ; Petraglia, G. ; Rosa Diez, G. ; Douthat, W. ; Lobo, J. ; Gallart, C. ; Lafalla, A. ; Diez, G. ; Linares, B. ; Lopez, N. ; Ramirez, N. ; Gonzalez, R. ; Valtuille, R. ; Beresan, H. ; Hermida, O. ; Rudolf, G. ; Marchetta, N. ; Rano, M. ; Ramirez, M. ; García, N. ; Gillies, A. ; Jones, B. ; Pedagogos, E. ; Walker, R. ; Talaulikar, G. ; Bannister, K. ; Suranyi, M. ; Kark, A. ; Roger, S. ; Kerr, P. ; Disney, A. ; Mount, P. ; Fraenkel, M. ; Mathew, M. ; Fassett, R. ; Jose, M. ; Hawley, C. ; Lonergan, M. ; Mackie, J. ; Ferrari, P. ; Menahem, S. ; Sabto, J. ; Hutchison, B. ; Langham, R. ; Pollock, C. ; Holzer, H. ; Oberbauer, R. ; Arias, I. ; Graf, H. ; Mayer, G. ; Lhotta, K. ; Neyer, U. ; Klauser, R. ; Hoerl, W. ; Horn, S. ; Kovarik, J. ; Kramar, R. ; Eigner, M. ; Dhaene, M. ; Billiouw, J. ; De Meester, J. ; Warling, X. ; Cambier-Dwelschauwers, P. ; Evenepoel, P. ; Daelemans, R. ; Dratwa, M. ; Maes, B. ; Stolear, J. ; Dejagere, T. ; Vanwalleghem, J. ; Bouman, K. ; Jadoul, M. ; Peeters, J. ; Vanholder, R. ; Tielemans, C. ; Donck, J. ; Almeida, F. ; Picollo De Oliveira, J. ; Burdmann, E. ; Garcia, V. ; Saldanha Thome, F. ; Deboni, L. ; Bregman, R. ; Lugon, J. ; Araújo, S. ; Ferreira Filho, S. ; De Francesco Daher, E. ; Sperto Baptista, M. ; Carvalho, A. ; D'Avila, D. ; Moyses Neto, M. ; Yu, L. ; Bastos, M. ; Sampaio Lacativa, P. ; Jorgetti, V. ; De Almeida Romão, E. ; Cardeal Da Costa, J. ; Pecoits Filho, R. ; Gordan, P. ; Salgado, N. ; Teixeira Araújo, M. ; Neiva Coelho, S. ; Oliveira, I. ; Moysés, R. ; Vasconcellos, L. ; Batista, P. ; Luiz Gross, J. ; Pedrosa, A. ; Cournoyer, S. ; LeBlanc, M. ; Chow, S. ; Karunakaran, S. ; Wong, G. ; Tobe, S. ; Desmeules, S. ; Zimmerman, D. ; Murphy, S. ; Montambault, P. ; Donnelly, S. ; MacRae, J. ; Culleton, B. ; Soroka, S. ; Rabbat, C. ; Jindal, K. ; Vasilevsky, M. ; Michaud, M. ; Wijeyesinghe, E. ; Zacharias, J. ; Lok, C. ; Muirhead, N. ; Verrelli, M. ; Da Roza, G. ; Sapir, D. ; Olgaard, K. ; Daugaard, H. ; Brandi, L. ; Jensen, P. ; Boulechfar, H. ; Ang, K. ; Simon, P. ; Rieu, P. ; Brunet, P. ; Touchard, G. ; Urena Torres, P. ; Combe, C. ; Durrbach, A. ; Ortiz, J. ; Hannedouche, T. ; Vela, C. ; Lionet, A. ; Ryckelynck, P. ; Zaoui, P. ; Choukroun, G. ; Fessi, H. ; Lang, P. ; Stroumza, P. ; Joly, D. ; Mousson, C. ; Laville, M. ; Dellanna, F. ; Erley, C. ; Braun, J. ; Rambausek, M. ; Riegel, W. ; Klingberg, M. ; Schwertfeger, E. ; Wizemann, V. ; Eckardt, K. ; Reichel, H. ; Passauer, J. ; Hübel, E. ; Frischmuth, N. ; Liebl, R. ; Fiedler, R. ; Schwenger, V. ; Voßkühler, A. ; Kunzendorf, U. ; Renders, L. ; Rattensberger, D. ; Rump, L. ; Ketteler, M. ; Neumayer, H. ; Zantvoort, F. ; Stahl, R. ; Ladanyi, E. ; Kulcsar, I. ; Mezei, I. ; Csiky, B. ; Rikker, C. ; Arkossy, O. ; Berta, K. ; Szegedi, J. ; Major, L. ; Ferenczi, S. ; Fekete, A. ; Szabo, T. ; Zakar, G. ; Wagner, G. ; Kazup Erdelyine, S. ; Borbas, B. ; Eustace, J. ; Reddan, D. ; Capasso, G. ; Locatelli, F. ; Villa, G. ; Cozzolino, M. ; Brancaccio, D. ; Messa, P. ; Bolasco, P. ; Ricciardi, B. ; Malberti, F. ; Moriero, E. ; Cannella, G. ; Ortalda, V. ; Stefoni, S. ; Frascà, G. ; Cappelli, G. ; Albertazzi, A. ; Zoccali, C. ; Farina, M. ; Elli, A. ; Avella, F. ; Ondei, P. ; Mingardi, G. ; Errico, R. ; Losito, A. ; Di Giulio, S. ; Pertosa, G. ; Schena, F. ; Grandaliano, G. ; Gesualdo, L. ; Auricchio, M. ; Bochicchio-Ricardelli, T. ; Aranda Verástegui, F. ; Peña, J. ; Chew Wong, A. ; Cruz-Valdez, J. ; Torres Zamora, M. ; Solis, M. ; Sebastian Diaz, M. ; Vital Flores, M. ; Alvarez Sandoval, E. ; Van Den Dorpel, M. ; Brink, H. ; Van Kuijk, W. ; Vermeij, C. ; Smak Gregoor, P. ; Hagen, E. ; Van Der Sande, F. ; Klinger, M. ; Nowicki, M. ; Muszytowski, M. ; Bidas, K. ; Bentkowski, W. ; Wiecek, A. ; Ksiazek, A. ; Marczewski, K. ; Ostrowski, M. ; Switalski, M. ; Sulowicz, W. ; Matuszkiewicz-Rowinska, J. ; Mysliwiec, M. ; Durlik, M. ; Rutkowski, B. ; Macario, F. ; Carvalho, B. ; Frazao, J. ; Machado, D. ; Weigert, A. ; Andrusev, A. ; Khrustalev, O. ; Zemtchenkov, A. ; Gurevich, K. ; Staroselsky, K. ; Khadikova, N. ; Rozhinskaya, L. ; Timokhovskaya, G. ; Strokov, A. ; Balkarova, O. ; Ermolenko, V. ; Kolmakova, E. ; Komandenko, M. ; Timofeev, M. ; Shilo, V. ; Shostka, G. ; Smirnov, A. ; Anashkin, V. ; Volgina, G. ; Domashenko, O. ; Gurevich, A. ; Perlin, D. ; Martínez García, J. ; Andrés Ribes, E. ; Coll Piera, E. ; Fernandez Lucas, M. ; Galicia, M. ; Prados, M. ; González, M. ; Romero, R. ; Martín De Francisco, De Francisco ; Montenegro, J. ; Santiago, C. ; García, F. ; Alcázar De La Ossa, J. ; Arrieta, J. ; Pons, J. ; Martín-Malo, A. ; Soler Amigó, J. ; Cases, A. ; Sterner, G. ; Jensen, G. ; Wikström, B. ; Jacobson, S. ; Lund, U. ; Weiss, L. ; Ståhl, A. ; Von Albertini, B. ; Burnier, M. ; Meier, P. ; Martin, P. ; Uehlinger, D. ; Dickenmann, M. ; Yaqoob, M. ; Zehnder, D. ; Kalra, P. ; Padmanabhan, N. ; Roe, S. ; Eadington, D. ; Pritchard, N. ; Hutchison, A. ; Davies, S. ; Wilkie, M. ; Davies, M. ; Pai, P. ; Swift, P. ; Kwan, J. ; Goldsmith, D. ; Tomson, C. ; Stratton, J. ; Dasgupta, I. ; Sarkar, S. ; Moustafa, M. ; Gandhi, K. ; Jamal, A. ; Galindo-Ramos, E. ; Tuazon, J. ; Batlle, D. ; Tucker, K. ; Schiller-Moran, B. ; Assefi, A. ; Martinez, C. ; Samuels, L. ; Goldman, J. ; Cangiano-Rivera, J. ; Darwish, R. ; Lee, M. ; Topf, J. ; Kapatkin, K. ; Baer, H. ; Kopelman, R. ; Acharya, M. ; Tharpe, D. ; Bernardo, M. ; Nader, P. ; Guzman-Rivera, J. ; Pergola, P. ; Sekkarie, M. ; Alas, E. ; Zager, P. ; Liss, K. ; Navarro, J. ; Roppolo, M. ; Denu-Ciocca, C. ; Kshirsagar, A. ; El Khatib, M. ; Kant, K. ; Scott, D. ; Murthyr, B. ; Finkelstein, F. ; Keightley, G. ; McCrary, R. ; Pitone, J. ; Cavalieri, T. ; Tsang, A. ; Pellegrino, B. ; Schmidt, R. ; Ahmad, S. ; Brown, C. ; Friedman, E. ; Mittman, N. ; Fadem, S. ; Shapiro, W. ; Reddy, M. ; Goldberger, S. ; Woredekal, Y. ; Agarwal, A. ; Anger, M. ; Haque, M. ; Chidester, P. ; Kohli, R. ; Rubinstein, S. ; Newman, G. ; Gladish, R. ; Ayodeji, O. ; Soman, S. ; Sprague, S. ; Hunt, N. ; Gehr, T. ; Rizk, D. ; Warnock, D. ; Polack, D. ; Pahl, M. ; Fischer, D. ; Dreyer, P. ; James, G. ; Husserl, F. ; Rogers, T. ; Raff, A. ; Sedor, J. ; Silver, M. ; Smith, M. ; Steinberg, S. ; DelGiorno, T. ; Jones, E. ; D Cunha, P. ; Cheng, J. ; Pogue, V. ; Blumenthal, S. ; Brown, E. ; Charytan, C. ; Buerkert, J. ; Cook, M. ; Felsenfeld, A. ; Tareen, N. ; Gupta, A. ; Herman, T. ; Diamond, S. ; Hura, C. ; Laski, M. ; MacLaurin, J. ; Plumb, T. ; Brosnahan, G. ; Kumar, J. ; Henriquez, M. ; Poole, C. ; Osanloo, E. ; Matalon, A. ; Sholer, C. ; Arfeen, S. ; Azer, M. ; Belledonne, M. ; Gross, M. ; Dunnigan, E. ; McConnell, K. ; Becker, B. ; Skinner, F. ; Rigolosi, R. ; Spiegel, D. ; Stegman, M. ; Patak, R. ; Streja, D. ; Ranjit, U. ; Youell, T. ; Wooldridge, T. ; Stafford, C. ; Cottiero, R. ; Weinberg, M. ; Schonefeld, M. ; Shahmir, E. ; Hazzan, A. ; Ashfaq, A. ; Bhandari, K. ; Cleveland, W. ; Culpepper, M. ; Golden, J. ; Lai, L. ; Lien, Y. ; Lorica, V. ; Robertson, J. ; Malireddi, K. ; Morse, S. ; Thakur, V. ; Israelit, A. ; Raguram, P. ; Alfred, H. ; Weise, W. ; Al-Saghir, F. ; El Shahawy, M. ; Rastogi, A. ; Nissenson, A. ; Kopyt, N. ; Lynn, R. ; Lea, J. ; McClellan, W. ; Teredesai, P. ; Ong, S. ; Tolkan, S. ; Sugihara, J. ; Minga, T. ; Mehrotra, R. ; Minasian, R. ; Bhatia, D. ; Specter, R. ; Capelli, J. ; Sidhu, P. ; Dalal, S. ; Dykes, P. ; Khan, M. ; Rahim, F. ; Saklayen, M. ; Thomas, A. ; Michael, B. ; Torres, M. ; Al-Bander, H. ; Murray, B. ; Abukurah, A. ; Gupta, B. ; Nosrati, S. ; Raja, R. ; Zeig, S. ; Braun, M. ; Amatya, A. ; Endsley, J. ; Sharon, Z. ; Gupta, A. ; Dolson, G. ; Dumler, F. ; Ntoso, K. ; Rosansky, S. ; Kumar, N. ; Gura, V. ; Thompson, N. ; Goldfarb, D. ; Halligan, R. ; Middleton, J. ; Widerhorn, A. ; Arbeit, L. ; Arruda, J. ; Crouch, T. ; Friedman, L. ; Khokhar, S. ; Mittleman, J. ; Light, P. ; Taparia, B. ; West, C. ; Cotton, J. ; Dhingra, R. ; Kleinman, L. ; Arif, F. ; Lew, S. ; Nammour, T. ; Sterrett, J. ; Williams, M. ; Ramirez, J. ; Rubin, J. ; McCarthy, J. ; Noble, S. ; Chaffin, M. ; Rekhi, A. / Cinacalcet, fibroblast growth factor-23, and cardiovascular disease in hemodialysis : The evaluation of cinacalcet HCl therapy to lower cardiovascular events (EVOLVE) trial. In: Circulation. 2015 ; Vol. 132, No. 1. pp. 27-39.
@article{9c4c738c273f482192c612f1635039d5,
title = "Cinacalcet, fibroblast growth factor-23, and cardiovascular disease in hemodialysis: The evaluation of cinacalcet HCl therapy to lower cardiovascular events (EVOLVE) trial",
abstract = "Background-Patients with kidney disease have disordered bone and mineral metabolism, including elevated serum concentrations of fibroblast growth factor-23 (FGF23). These elevated concentrations are associated with cardiovascular and all-cause mortality. The objective was to determine the effects of the calcimimetic cinacalcet (versus placebo) on reducing serum FGF23 and whether changes in FGF23 are associated with death and cardiovascular events. Methods and Results-This was a secondary analysis of a randomized clinical trial comparing cinacalcet to placebo in addition to conventional therapy (phosphate binders/vitamin D) in patients receiving hemodialysis with secondary hyperparathyroidism (intact parathyroid hormone ≥300 pg/mL). The primary study end point was time to death or a first nonfatal cardiovascular event (myocardial infarction, hospitalization for angina, heart failure, or a peripheral vascular event). This analysis included 2985 patients (77{\%} of randomized) with serum samples at baseline and 2602 patients (67{\%}) with samples at both baseline and week 20. The results demonstrated that a significantly larger proportion of patients randomized to cinacalcet had ≥30{\%} (68{\%} versus 28{\%}) reductions in FGF23. Among patients randomized to cinacalcet, a ≥30{\%} reduction in FGF23 between baseline and week 20 was associated with a nominally significant reduction in the primary composite end point (relative hazard, 0.82; 95{\%} confidence interval, 0.69-0.98), cardiovascular mortality (relative hazard, 0.66; 95{\%} confidence interval, 0.50-0.87), sudden cardiac death (relative hazard, 0.57; 95{\%} confidence interval, 0.37-0.86), and heart failure (relative hazard, 0.69; 95{\%} confidence interval, 0.48-0.99). Conclusions-Treatment with cinacalcet significantly lowers serum FGF23. Treatment-induced reductions in serum FGF23 are associated with lower rates of cardiovascular death and major cardiovascular events.",
keywords = "Arrhythmias, Calcium, Cardiac, Cardiac, Chronic, Death, Renal insufficiency, Sudden, Ventricular remodeling",
author = "Sharon Moe and Chertow, {Glenn M.} and Parfrey, {Patrick S.} and Yumi Kubo and Block, {Geoffrey A.} and Ricardo Correa-Rotter and Dr{\"u}eke, {Tilman B.} and Herzog, {Charles A.} and London, {Gerard M.} and Mahaffey, {Kenneth W.} and Wheeler, {David C.} and Maria Stolina and Bastian Dehmel and Goodman, {William G.} and J{\"u}rgen Floege and J. Santos and {Najun Zarazaga}, C. and I. Marin and N. Garrote and A. Cusumano and N. Pe{\~n}alba and {Del Valle}, E. and L. Juncos and {Martinez Saye}, J. and L. Lef and V. Altobelli and G. Petraglia and {Rosa Diez}, G. and W. Douthat and J. Lobo and C. Gallart and A. Lafalla and G. Diez and B. Linares and N. Lopez and N. Ramirez and R. Gonzalez and R. Valtuille and H. Beresan and O. Hermida and G. Rudolf and N. Marchetta and M. Rano and M. Ramirez and N. Garc{\'i}a and A. Gillies and B. Jones and E. Pedagogos and R. Walker and G. Talaulikar and K. Bannister and M. Suranyi and A. Kark and S. Roger and P. Kerr and A. Disney and P. Mount and M. Fraenkel and M. Mathew and R. Fassett and M. Jose and C. Hawley and M. Lonergan and J. Mackie and P. Ferrari and S. Menahem and J. Sabto and B. Hutchison and R. Langham and C. Pollock and H. Holzer and R. Oberbauer and I. Arias and H. Graf and G. Mayer and K. Lhotta and U. Neyer and R. Klauser and W. Hoerl and S. Horn and J. Kovarik and R. Kramar and M. Eigner and M. Dhaene and J. Billiouw and {De Meester}, J. and X. Warling and P. Cambier-Dwelschauwers and P. Evenepoel and R. Daelemans and M. Dratwa and B. Maes and J. Stolear and T. Dejagere and J. Vanwalleghem and K. Bouman and M. Jadoul and J. Peeters and R. Vanholder and C. Tielemans and J. Donck and F. Almeida and {Picollo De Oliveira}, J. and E. Burdmann and V. Garcia and {Saldanha Thome}, F. and L. Deboni and R. Bregman and J. Lugon and S. Ara{\'u}jo and {Ferreira Filho}, S. and {De Francesco Daher}, E. and {Sperto Baptista}, M. and A. Carvalho and D. D'Avila and {Moyses Neto}, M. and L. Yu and M. Bastos and {Sampaio Lacativa}, P. and V. Jorgetti and {De Almeida Rom{\~a}o}, E. and {Cardeal Da Costa}, J. and {Pecoits Filho}, R. and P. Gordan and N. Salgado and {Teixeira Ara{\'u}jo}, M. and {Neiva Coelho}, S. and I. Oliveira and R. Moys{\'e}s and L. Vasconcellos and P. Batista and {Luiz Gross}, J. and A. Pedrosa and S. Cournoyer and M. LeBlanc and S. Chow and S. Karunakaran and G. Wong and S. Tobe and S. Desmeules and D. Zimmerman and S. Murphy and P. Montambault and S. Donnelly and J. MacRae and B. Culleton and S. Soroka and C. Rabbat and K. Jindal and M. Vasilevsky and M. Michaud and E. Wijeyesinghe and J. Zacharias and C. Lok and N. Muirhead and M. Verrelli and {Da Roza}, G. and D. Sapir and K. Olgaard and H. Daugaard and L. Brandi and P. Jensen and H. Boulechfar and K. Ang and P. Simon and P. Rieu and P. Brunet and G. Touchard and {Urena Torres}, P. and C. Combe and A. Durrbach and J. Ortiz and T. Hannedouche and C. Vela and A. Lionet and P. Ryckelynck and P. Zaoui and G. Choukroun and H. Fessi and P. Lang and P. Stroumza and D. Joly and C. Mousson and M. Laville and F. Dellanna and C. Erley and J. Braun and M. Rambausek and W. Riegel and M. Klingberg and E. Schwertfeger and V. Wizemann and K. Eckardt and H. Reichel and J. Passauer and E. H{\"u}bel and N. Frischmuth and R. Liebl and R. Fiedler and V. Schwenger and A. Vo{\ss}k{\"u}hler and U. Kunzendorf and L. Renders and D. Rattensberger and L. Rump and M. Ketteler and H. Neumayer and F. Zantvoort and R. Stahl and E. Ladanyi and I. Kulcsar and I. Mezei and B. Csiky and C. Rikker and O. Arkossy and K. Berta and J. Szegedi and L. Major and S. Ferenczi and A. Fekete and T. Szabo and G. Zakar and G. Wagner and {Kazup Erdelyine}, S. and B. Borbas and J. Eustace and D. Reddan and G. Capasso and F. Locatelli and G. Villa and M. Cozzolino and D. Brancaccio and P. Messa and P. Bolasco and B. Ricciardi and F. Malberti and E. Moriero and G. Cannella and V. Ortalda and S. Stefoni and G. Frasc{\`a} and G. Cappelli and A. Albertazzi and C. Zoccali and M. Farina and A. Elli and F. Avella and P. Ondei and G. Mingardi and R. Errico and A. Losito and {Di Giulio}, S. and G. Pertosa and F. Schena and G. Grandaliano and L. Gesualdo and M. Auricchio and T. Bochicchio-Ricardelli and {Aranda Ver{\'a}stegui}, F. and J. Pe{\~n}a and {Chew Wong}, A. and J. Cruz-Valdez and {Torres Zamora}, M. and M. Solis and {Sebastian Diaz}, M. and {Vital Flores}, M. and {Alvarez Sandoval}, E. and {Van Den Dorpel}, M. and H. Brink and {Van Kuijk}, W. and C. Vermeij and {Smak Gregoor}, P. and E. Hagen and {Van Der Sande}, F. and M. Klinger and M. Nowicki and M. Muszytowski and K. Bidas and W. Bentkowski and A. Wiecek and A. Ksiazek and K. Marczewski and M. Ostrowski and M. Switalski and W. Sulowicz and J. Matuszkiewicz-Rowinska and M. Mysliwiec and M. Durlik and B. Rutkowski and F. Macario and B. Carvalho and J. Frazao and D. Machado and A. Weigert and A. Andrusev and O. Khrustalev and A. Zemtchenkov and K. Gurevich and K. Staroselsky and N. Khadikova and L. Rozhinskaya and G. Timokhovskaya and A. Strokov and O. Balkarova and V. Ermolenko and E. Kolmakova and M. Komandenko and M. Timofeev and V. Shilo and G. Shostka and A. Smirnov and V. Anashkin and G. Volgina and O. Domashenko and A. Gurevich and D. Perlin and {Mart{\'i}nez Garc{\'i}a}, J. and {Andr{\'e}s Ribes}, E. and {Coll Piera}, E. and {Fernandez Lucas}, M. and M. Galicia and M. Prados and M. Gonz{\'a}lez and R. Romero and {Mart{\'i}n De Francisco}, {De Francisco} and J. Montenegro and C. Santiago and F. Garc{\'i}a and {Alc{\'a}zar De La Ossa}, J. and J. Arrieta and J. Pons and A. Mart{\'i}n-Malo and {Soler Amig{\'o}}, J. and A. Cases and G. Sterner and G. Jensen and B. Wikstr{\"o}m and S. Jacobson and U. Lund and L. Weiss and A. St{\aa}hl and {Von Albertini}, B. and M. Burnier and P. Meier and P. Martin and D. Uehlinger and M. Dickenmann and M. Yaqoob and D. Zehnder and P. Kalra and N. Padmanabhan and S. Roe and D. Eadington and N. Pritchard and A. Hutchison and S. Davies and M. Wilkie and M. Davies and P. Pai and P. Swift and J. Kwan and D. Goldsmith and C. Tomson and J. Stratton and I. Dasgupta and S. Sarkar and M. Moustafa and K. Gandhi and A. Jamal and E. Galindo-Ramos and J. Tuazon and D. Batlle and K. Tucker and B. Schiller-Moran and A. Assefi and C. Martinez and L. Samuels and J. Goldman and J. Cangiano-Rivera and R. Darwish and M. Lee and J. Topf and K. Kapatkin and H. Baer and R. Kopelman and M. Acharya and D. Tharpe and M. Bernardo and P. Nader and J. Guzman-Rivera and P. Pergola and M. Sekkarie and E. Alas and P. Zager and K. Liss and J. Navarro and M. Roppolo and C. Denu-Ciocca and A. Kshirsagar and {El Khatib}, M. and K. Kant and D. Scott and B. Murthyr and F. Finkelstein and G. Keightley and R. McCrary and J. Pitone and T. Cavalieri and A. Tsang and B. Pellegrino and R. Schmidt and S. Ahmad and C. Brown and E. Friedman and N. Mittman and S. Fadem and W. Shapiro and M. Reddy and S. Goldberger and Y. Woredekal and A. Agarwal and M. Anger and M. Haque and P. Chidester and R. Kohli and S. Rubinstein and G. Newman and R. Gladish and O. Ayodeji and S. Soman and S. Sprague and N. Hunt and T. Gehr and D. Rizk and D. Warnock and D. Polack and M. Pahl and D. Fischer and P. Dreyer and G. James and F. Husserl and T. Rogers and A. Raff and J. Sedor and M. Silver and M. Smith and S. Steinberg and T. DelGiorno and E. Jones and {D Cunha}, P. and J. Cheng and V. Pogue and S. Blumenthal and E. Brown and C. Charytan and J. Buerkert and M. Cook and A. Felsenfeld and N. Tareen and A. Gupta and T. Herman and S. Diamond and C. Hura and M. Laski and J. MacLaurin and T. Plumb and G. Brosnahan and J. Kumar and M. Henriquez and C. Poole and E. Osanloo and A. Matalon and C. Sholer and S. Arfeen and M. Azer and M. Belledonne and M. Gross and E. Dunnigan and K. McConnell and B. Becker and F. Skinner and R. Rigolosi and D. Spiegel and M. Stegman and R. Patak and D. Streja and U. Ranjit and T. Youell and T. Wooldridge and C. Stafford and R. Cottiero and M. Weinberg and M. Schonefeld and E. Shahmir and A. Hazzan and A. Ashfaq and K. Bhandari and W. Cleveland and M. Culpepper and J. Golden and L. Lai and Y. Lien and V. Lorica and J. Robertson and K. Malireddi and S. Morse and V. Thakur and A. Israelit and P. Raguram and H. Alfred and W. Weise and F. Al-Saghir and {El Shahawy}, M. and A. Rastogi and A. Nissenson and N. Kopyt and R. Lynn and J. Lea and W. McClellan and P. Teredesai and S. Ong and S. Tolkan and J. Sugihara and T. Minga and R. Mehrotra and R. Minasian and D. Bhatia and R. Specter and J. Capelli and P. Sidhu and S. Dalal and P. Dykes and M. Khan and F. Rahim and M. Saklayen and A. Thomas and B. Michael and M. Torres and H. Al-Bander and B. Murray and A. Abukurah and B. Gupta and S. Nosrati and R. Raja and S. Zeig and M. Braun and A. Amatya and J. Endsley and Z. Sharon and A. Gupta and G. Dolson and F. Dumler and K. Ntoso and S. Rosansky and N. Kumar and V. Gura and N. Thompson and D. Goldfarb and R. Halligan and J. Middleton and A. Widerhorn and L. Arbeit and J. Arruda and T. Crouch and L. Friedman and S. Khokhar and J. Mittleman and P. Light and B. Taparia and C. West and J. Cotton and R. Dhingra and L. Kleinman and F. Arif and S. Lew and T. Nammour and J. Sterrett and M. Williams and J. Ramirez and J. Rubin and J. McCarthy and S. Noble and M. Chaffin and A. Rekhi",
year = "2015",
doi = "10.1161/CIRCULATIONAHA.114.013876",
language = "English",
volume = "132",
pages = "27--39",
journal = "Circulation",
issn = "0009-7322",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Cinacalcet, fibroblast growth factor-23, and cardiovascular disease in hemodialysis

T2 - The evaluation of cinacalcet HCl therapy to lower cardiovascular events (EVOLVE) trial

AU - Moe, Sharon

AU - Chertow, Glenn M.

AU - Parfrey, Patrick S.

AU - Kubo, Yumi

AU - Block, Geoffrey A.

AU - Correa-Rotter, Ricardo

AU - Drüeke, Tilman B.

AU - Herzog, Charles A.

AU - London, Gerard M.

AU - Mahaffey, Kenneth W.

AU - Wheeler, David C.

AU - Stolina, Maria

AU - Dehmel, Bastian

AU - Goodman, William G.

AU - Floege, Jürgen

AU - Santos, J.

AU - Najun Zarazaga, C.

AU - Marin, I.

AU - Garrote, N.

AU - Cusumano, A.

AU - Peñalba, N.

AU - Del Valle, E.

AU - Juncos, L.

AU - Martinez Saye, J.

AU - Lef, L.

AU - Altobelli, V.

AU - Petraglia, G.

AU - Rosa Diez, G.

AU - Douthat, W.

AU - Lobo, J.

AU - Gallart, C.

AU - Lafalla, A.

AU - Diez, G.

AU - Linares, B.

AU - Lopez, N.

AU - Ramirez, N.

AU - Gonzalez, R.

AU - Valtuille, R.

AU - Beresan, H.

AU - Hermida, O.

AU - Rudolf, G.

AU - Marchetta, N.

AU - Rano, M.

AU - Ramirez, M.

AU - García, N.

AU - Gillies, A.

AU - Jones, B.

AU - Pedagogos, E.

AU - Walker, R.

AU - Talaulikar, G.

AU - Bannister, K.

AU - Suranyi, M.

AU - Kark, A.

AU - Roger, S.

AU - Kerr, P.

AU - Disney, A.

AU - Mount, P.

AU - Fraenkel, M.

AU - Mathew, M.

AU - Fassett, R.

AU - Jose, M.

AU - Hawley, C.

AU - Lonergan, M.

AU - Mackie, J.

AU - Ferrari, P.

AU - Menahem, S.

AU - Sabto, J.

AU - Hutchison, B.

AU - Langham, R.

AU - Pollock, C.

AU - Holzer, H.

AU - Oberbauer, R.

AU - Arias, I.

AU - Graf, H.

AU - Mayer, G.

AU - Lhotta, K.

AU - Neyer, U.

AU - Klauser, R.

AU - Hoerl, W.

AU - Horn, S.

AU - Kovarik, J.

AU - Kramar, R.

AU - Eigner, M.

AU - Dhaene, M.

AU - Billiouw, J.

AU - De Meester, J.

AU - Warling, X.

AU - Cambier-Dwelschauwers, P.

AU - Evenepoel, P.

AU - Daelemans, R.

AU - Dratwa, M.

AU - Maes, B.

AU - Stolear, J.

AU - Dejagere, T.

AU - Vanwalleghem, J.

AU - Bouman, K.

AU - Jadoul, M.

AU - Peeters, J.

AU - Vanholder, R.

AU - Tielemans, C.

AU - Donck, J.

AU - Almeida, F.

AU - Picollo De Oliveira, J.

AU - Burdmann, E.

AU - Garcia, V.

AU - Saldanha Thome, F.

AU - Deboni, L.

AU - Bregman, R.

AU - Lugon, J.

AU - Araújo, S.

AU - Ferreira Filho, S.

AU - De Francesco Daher, E.

AU - Sperto Baptista, M.

AU - Carvalho, A.

AU - D'Avila, D.

AU - Moyses Neto, M.

AU - Yu, L.

AU - Bastos, M.

AU - Sampaio Lacativa, P.

AU - Jorgetti, V.

AU - De Almeida Romão, E.

AU - Cardeal Da Costa, J.

AU - Pecoits Filho, R.

AU - Gordan, P.

AU - Salgado, N.

AU - Teixeira Araújo, M.

AU - Neiva Coelho, S.

AU - Oliveira, I.

AU - Moysés, R.

AU - Vasconcellos, L.

AU - Batista, P.

AU - Luiz Gross, J.

AU - Pedrosa, A.

AU - Cournoyer, S.

AU - LeBlanc, M.

AU - Chow, S.

AU - Karunakaran, S.

AU - Wong, G.

AU - Tobe, S.

AU - Desmeules, S.

AU - Zimmerman, D.

AU - Murphy, S.

AU - Montambault, P.

AU - Donnelly, S.

AU - MacRae, J.

AU - Culleton, B.

AU - Soroka, S.

AU - Rabbat, C.

AU - Jindal, K.

AU - Vasilevsky, M.

AU - Michaud, M.

AU - Wijeyesinghe, E.

AU - Zacharias, J.

AU - Lok, C.

AU - Muirhead, N.

AU - Verrelli, M.

AU - Da Roza, G.

AU - Sapir, D.

AU - Olgaard, K.

AU - Daugaard, H.

AU - Brandi, L.

AU - Jensen, P.

AU - Boulechfar, H.

AU - Ang, K.

AU - Simon, P.

AU - Rieu, P.

AU - Brunet, P.

AU - Touchard, G.

AU - Urena Torres, P.

AU - Combe, C.

AU - Durrbach, A.

AU - Ortiz, J.

AU - Hannedouche, T.

AU - Vela, C.

AU - Lionet, A.

AU - Ryckelynck, P.

AU - Zaoui, P.

AU - Choukroun, G.

AU - Fessi, H.

AU - Lang, P.

AU - Stroumza, P.

AU - Joly, D.

AU - Mousson, C.

AU - Laville, M.

AU - Dellanna, F.

AU - Erley, C.

AU - Braun, J.

AU - Rambausek, M.

AU - Riegel, W.

AU - Klingberg, M.

AU - Schwertfeger, E.

AU - Wizemann, V.

AU - Eckardt, K.

AU - Reichel, H.

AU - Passauer, J.

AU - Hübel, E.

AU - Frischmuth, N.

AU - Liebl, R.

AU - Fiedler, R.

AU - Schwenger, V.

AU - Voßkühler, A.

AU - Kunzendorf, U.

AU - Renders, L.

AU - Rattensberger, D.

AU - Rump, L.

AU - Ketteler, M.

AU - Neumayer, H.

AU - Zantvoort, F.

AU - Stahl, R.

AU - Ladanyi, E.

AU - Kulcsar, I.

AU - Mezei, I.

AU - Csiky, B.

AU - Rikker, C.

AU - Arkossy, O.

AU - Berta, K.

AU - Szegedi, J.

AU - Major, L.

AU - Ferenczi, S.

AU - Fekete, A.

AU - Szabo, T.

AU - Zakar, G.

AU - Wagner, G.

AU - Kazup Erdelyine, S.

AU - Borbas, B.

AU - Eustace, J.

AU - Reddan, D.

AU - Capasso, G.

AU - Locatelli, F.

AU - Villa, G.

AU - Cozzolino, M.

AU - Brancaccio, D.

AU - Messa, P.

AU - Bolasco, P.

AU - Ricciardi, B.

AU - Malberti, F.

AU - Moriero, E.

AU - Cannella, G.

AU - Ortalda, V.

AU - Stefoni, S.

AU - Frascà, G.

AU - Cappelli, G.

AU - Albertazzi, A.

AU - Zoccali, C.

AU - Farina, M.

AU - Elli, A.

AU - Avella, F.

AU - Ondei, P.

AU - Mingardi, G.

AU - Errico, R.

AU - Losito, A.

AU - Di Giulio, S.

AU - Pertosa, G.

AU - Schena, F.

AU - Grandaliano, G.

AU - Gesualdo, L.

AU - Auricchio, M.

AU - Bochicchio-Ricardelli, T.

AU - Aranda Verástegui, F.

AU - Peña, J.

AU - Chew Wong, A.

AU - Cruz-Valdez, J.

AU - Torres Zamora, M.

AU - Solis, M.

AU - Sebastian Diaz, M.

AU - Vital Flores, M.

AU - Alvarez Sandoval, E.

AU - Van Den Dorpel, M.

AU - Brink, H.

AU - Van Kuijk, W.

AU - Vermeij, C.

AU - Smak Gregoor, P.

AU - Hagen, E.

AU - Van Der Sande, F.

AU - Klinger, M.

AU - Nowicki, M.

AU - Muszytowski, M.

AU - Bidas, K.

AU - Bentkowski, W.

AU - Wiecek, A.

AU - Ksiazek, A.

AU - Marczewski, K.

AU - Ostrowski, M.

AU - Switalski, M.

AU - Sulowicz, W.

AU - Matuszkiewicz-Rowinska, J.

AU - Mysliwiec, M.

AU - Durlik, M.

AU - Rutkowski, B.

AU - Macario, F.

AU - Carvalho, B.

AU - Frazao, J.

AU - Machado, D.

AU - Weigert, A.

AU - Andrusev, A.

AU - Khrustalev, O.

AU - Zemtchenkov, A.

AU - Gurevich, K.

AU - Staroselsky, K.

AU - Khadikova, N.

AU - Rozhinskaya, L.

AU - Timokhovskaya, G.

AU - Strokov, A.

AU - Balkarova, O.

AU - Ermolenko, V.

AU - Kolmakova, E.

AU - Komandenko, M.

AU - Timofeev, M.

AU - Shilo, V.

AU - Shostka, G.

AU - Smirnov, A.

AU - Anashkin, V.

AU - Volgina, G.

AU - Domashenko, O.

AU - Gurevich, A.

AU - Perlin, D.

AU - Martínez García, J.

AU - Andrés Ribes, E.

AU - Coll Piera, E.

AU - Fernandez Lucas, M.

AU - Galicia, M.

AU - Prados, M.

AU - González, M.

AU - Romero, R.

AU - Martín De Francisco, De Francisco

AU - Montenegro, J.

AU - Santiago, C.

AU - García, F.

AU - Alcázar De La Ossa, J.

AU - Arrieta, J.

AU - Pons, J.

AU - Martín-Malo, A.

AU - Soler Amigó, J.

AU - Cases, A.

AU - Sterner, G.

AU - Jensen, G.

AU - Wikström, B.

AU - Jacobson, S.

AU - Lund, U.

AU - Weiss, L.

AU - Ståhl, A.

AU - Von Albertini, B.

AU - Burnier, M.

AU - Meier, P.

AU - Martin, P.

AU - Uehlinger, D.

AU - Dickenmann, M.

AU - Yaqoob, M.

AU - Zehnder, D.

AU - Kalra, P.

AU - Padmanabhan, N.

AU - Roe, S.

AU - Eadington, D.

AU - Pritchard, N.

AU - Hutchison, A.

AU - Davies, S.

AU - Wilkie, M.

AU - Davies, M.

AU - Pai, P.

AU - Swift, P.

AU - Kwan, J.

AU - Goldsmith, D.

AU - Tomson, C.

AU - Stratton, J.

AU - Dasgupta, I.

AU - Sarkar, S.

AU - Moustafa, M.

AU - Gandhi, K.

AU - Jamal, A.

AU - Galindo-Ramos, E.

AU - Tuazon, J.

AU - Batlle, D.

AU - Tucker, K.

AU - Schiller-Moran, B.

AU - Assefi, A.

AU - Martinez, C.

AU - Samuels, L.

AU - Goldman, J.

AU - Cangiano-Rivera, J.

AU - Darwish, R.

AU - Lee, M.

AU - Topf, J.

AU - Kapatkin, K.

AU - Baer, H.

AU - Kopelman, R.

AU - Acharya, M.

AU - Tharpe, D.

AU - Bernardo, M.

AU - Nader, P.

AU - Guzman-Rivera, J.

AU - Pergola, P.

AU - Sekkarie, M.

AU - Alas, E.

AU - Zager, P.

AU - Liss, K.

AU - Navarro, J.

AU - Roppolo, M.

AU - Denu-Ciocca, C.

AU - Kshirsagar, A.

AU - El Khatib, M.

AU - Kant, K.

AU - Scott, D.

AU - Murthyr, B.

AU - Finkelstein, F.

AU - Keightley, G.

AU - McCrary, R.

AU - Pitone, J.

AU - Cavalieri, T.

AU - Tsang, A.

AU - Pellegrino, B.

AU - Schmidt, R.

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PY - 2015

Y1 - 2015

N2 - Background-Patients with kidney disease have disordered bone and mineral metabolism, including elevated serum concentrations of fibroblast growth factor-23 (FGF23). These elevated concentrations are associated with cardiovascular and all-cause mortality. The objective was to determine the effects of the calcimimetic cinacalcet (versus placebo) on reducing serum FGF23 and whether changes in FGF23 are associated with death and cardiovascular events. Methods and Results-This was a secondary analysis of a randomized clinical trial comparing cinacalcet to placebo in addition to conventional therapy (phosphate binders/vitamin D) in patients receiving hemodialysis with secondary hyperparathyroidism (intact parathyroid hormone ≥300 pg/mL). The primary study end point was time to death or a first nonfatal cardiovascular event (myocardial infarction, hospitalization for angina, heart failure, or a peripheral vascular event). This analysis included 2985 patients (77% of randomized) with serum samples at baseline and 2602 patients (67%) with samples at both baseline and week 20. The results demonstrated that a significantly larger proportion of patients randomized to cinacalcet had ≥30% (68% versus 28%) reductions in FGF23. Among patients randomized to cinacalcet, a ≥30% reduction in FGF23 between baseline and week 20 was associated with a nominally significant reduction in the primary composite end point (relative hazard, 0.82; 95% confidence interval, 0.69-0.98), cardiovascular mortality (relative hazard, 0.66; 95% confidence interval, 0.50-0.87), sudden cardiac death (relative hazard, 0.57; 95% confidence interval, 0.37-0.86), and heart failure (relative hazard, 0.69; 95% confidence interval, 0.48-0.99). Conclusions-Treatment with cinacalcet significantly lowers serum FGF23. Treatment-induced reductions in serum FGF23 are associated with lower rates of cardiovascular death and major cardiovascular events.

AB - Background-Patients with kidney disease have disordered bone and mineral metabolism, including elevated serum concentrations of fibroblast growth factor-23 (FGF23). These elevated concentrations are associated with cardiovascular and all-cause mortality. The objective was to determine the effects of the calcimimetic cinacalcet (versus placebo) on reducing serum FGF23 and whether changes in FGF23 are associated with death and cardiovascular events. Methods and Results-This was a secondary analysis of a randomized clinical trial comparing cinacalcet to placebo in addition to conventional therapy (phosphate binders/vitamin D) in patients receiving hemodialysis with secondary hyperparathyroidism (intact parathyroid hormone ≥300 pg/mL). The primary study end point was time to death or a first nonfatal cardiovascular event (myocardial infarction, hospitalization for angina, heart failure, or a peripheral vascular event). This analysis included 2985 patients (77% of randomized) with serum samples at baseline and 2602 patients (67%) with samples at both baseline and week 20. The results demonstrated that a significantly larger proportion of patients randomized to cinacalcet had ≥30% (68% versus 28%) reductions in FGF23. Among patients randomized to cinacalcet, a ≥30% reduction in FGF23 between baseline and week 20 was associated with a nominally significant reduction in the primary composite end point (relative hazard, 0.82; 95% confidence interval, 0.69-0.98), cardiovascular mortality (relative hazard, 0.66; 95% confidence interval, 0.50-0.87), sudden cardiac death (relative hazard, 0.57; 95% confidence interval, 0.37-0.86), and heart failure (relative hazard, 0.69; 95% confidence interval, 0.48-0.99). Conclusions-Treatment with cinacalcet significantly lowers serum FGF23. Treatment-induced reductions in serum FGF23 are associated with lower rates of cardiovascular death and major cardiovascular events.

KW - Arrhythmias

KW - Calcium

KW - Cardiac

KW - Cardiac

KW - Chronic

KW - Death

KW - Renal insufficiency

KW - Sudden

KW - Ventricular remodeling

UR - http://www.scopus.com/inward/record.url?scp=84935451711&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84935451711&partnerID=8YFLogxK

U2 - 10.1161/CIRCULATIONAHA.114.013876

DO - 10.1161/CIRCULATIONAHA.114.013876

M3 - Article

C2 - 26059012

AN - SCOPUS:84935451711

VL - 132

SP - 27

EP - 39

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 1

ER -