Circadian clock control of hepatic lipid metabolism: Role of small heterodimer partner (Shp)

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Hepatic steatosis, the accumulation of triglyceride droplets in the hepatocytes, is a common hepatic pathology seen in subjects with obesity/metabolic syndrome and those with excessive alcohol use. The pathogenesis underlying hepatic steatosis is complex. Recent studies have shown the specific role played by the molecular clock mechanism in the control of lipid metabolism and that the disruption of these tissue clocks may lead to the disturbances in lipid homeostasis. This review reports a novel role of small heterodimer partner in maintaining triglyceride and lipoprotein homeostasis through neuronal PAS domain protein 2.

Original languageEnglish (US)
Pages (from-to)1158-1161
Number of pages4
JournalJournal of Investigative Medicine
Volume64
Issue number7
DOIs
StatePublished - Oct 1 2016

Keywords

  • Lipid Metabolism

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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