Circadian time-dependent kinetics of theophylline and its modulation by phenobarbital pretreatment in rats

Zeruesenay Desta, W. Siegmund, G. Franke, M. Zschiesche

Research output: Contribution to journalArticle

Abstract

The pharmacokinetics of theophylline (TPH, 10 mg/kg i.v.) were assessed in rats (natural light-dark span, June 9-10) after i.p. pretreatment with saline and 80 mg/kg phenobarbital (PB), respectively, for 3 consecutive days at either 07:00 h or at 19:000 h. Serum concentrations of TPH were assayed by high-performance liquid chromatography. No significant differences of the elimination rates of TPH could be found between the times of TPH administration (clearance: 1.17 ± 0.17 ml/kg/min at 07:00 h vs. 1.23 ± 0.17 ml/kg/min at 19:00 hours). PB premedication markedly accelerated TPH elimination. The increase in clearance values was more expressed when TPH was injected at 07:00 h than at 19:00 h (2.48 ± 0.67 vs. 2.06 ± 0.41 ml/kg/min, p <0.01). Key Words: Theophylline - Chronopharmacokinetics - Phenobarbital - Enzyme induction.

Original languageEnglish (US)
Pages (from-to)81-86
Number of pages6
JournalChronobiology International
Volume10
Issue number2
DOIs
StatePublished - 1993
Externally publishedYes

Fingerprint

theophylline
phenobarbital
Theophylline
Phenobarbital
pretreatment
kinetics
rats
Enzyme Induction
Premedication
gene induction
pharmacokinetics
solar radiation
Pharmacokinetics
high performance liquid chromatography
High Pressure Liquid Chromatography
Light
Serum

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Agricultural and Biological Sciences (miscellaneous)

Cite this

Circadian time-dependent kinetics of theophylline and its modulation by phenobarbital pretreatment in rats. / Desta, Zeruesenay; Siegmund, W.; Franke, G.; Zschiesche, M.

In: Chronobiology International, Vol. 10, No. 2, 1993, p. 81-86.

Research output: Contribution to journalArticle

@article{6a7f450894534630b8350f8de45fcdb3,
title = "Circadian time-dependent kinetics of theophylline and its modulation by phenobarbital pretreatment in rats",
abstract = "The pharmacokinetics of theophylline (TPH, 10 mg/kg i.v.) were assessed in rats (natural light-dark span, June 9-10) after i.p. pretreatment with saline and 80 mg/kg phenobarbital (PB), respectively, for 3 consecutive days at either 07:00 h or at 19:000 h. Serum concentrations of TPH were assayed by high-performance liquid chromatography. No significant differences of the elimination rates of TPH could be found between the times of TPH administration (clearance: 1.17 ± 0.17 ml/kg/min at 07:00 h vs. 1.23 ± 0.17 ml/kg/min at 19:00 hours). PB premedication markedly accelerated TPH elimination. The increase in clearance values was more expressed when TPH was injected at 07:00 h than at 19:00 h (2.48 ± 0.67 vs. 2.06 ± 0.41 ml/kg/min, p <0.01). Key Words: Theophylline - Chronopharmacokinetics - Phenobarbital - Enzyme induction.",
author = "Zeruesenay Desta and W. Siegmund and G. Franke and M. Zschiesche",
year = "1993",
doi = "10.1080/07420529309059695",
language = "English (US)",
volume = "10",
pages = "81--86",
journal = "Annual Review of Chronopharmacology",
issn = "0743-9539",
publisher = "Marcel Dekker Inc.",
number = "2",

}

TY - JOUR

T1 - Circadian time-dependent kinetics of theophylline and its modulation by phenobarbital pretreatment in rats

AU - Desta, Zeruesenay

AU - Siegmund, W.

AU - Franke, G.

AU - Zschiesche, M.

PY - 1993

Y1 - 1993

N2 - The pharmacokinetics of theophylline (TPH, 10 mg/kg i.v.) were assessed in rats (natural light-dark span, June 9-10) after i.p. pretreatment with saline and 80 mg/kg phenobarbital (PB), respectively, for 3 consecutive days at either 07:00 h or at 19:000 h. Serum concentrations of TPH were assayed by high-performance liquid chromatography. No significant differences of the elimination rates of TPH could be found between the times of TPH administration (clearance: 1.17 ± 0.17 ml/kg/min at 07:00 h vs. 1.23 ± 0.17 ml/kg/min at 19:00 hours). PB premedication markedly accelerated TPH elimination. The increase in clearance values was more expressed when TPH was injected at 07:00 h than at 19:00 h (2.48 ± 0.67 vs. 2.06 ± 0.41 ml/kg/min, p <0.01). Key Words: Theophylline - Chronopharmacokinetics - Phenobarbital - Enzyme induction.

AB - The pharmacokinetics of theophylline (TPH, 10 mg/kg i.v.) were assessed in rats (natural light-dark span, June 9-10) after i.p. pretreatment with saline and 80 mg/kg phenobarbital (PB), respectively, for 3 consecutive days at either 07:00 h or at 19:000 h. Serum concentrations of TPH were assayed by high-performance liquid chromatography. No significant differences of the elimination rates of TPH could be found between the times of TPH administration (clearance: 1.17 ± 0.17 ml/kg/min at 07:00 h vs. 1.23 ± 0.17 ml/kg/min at 19:00 hours). PB premedication markedly accelerated TPH elimination. The increase in clearance values was more expressed when TPH was injected at 07:00 h than at 19:00 h (2.48 ± 0.67 vs. 2.06 ± 0.41 ml/kg/min, p <0.01). Key Words: Theophylline - Chronopharmacokinetics - Phenobarbital - Enzyme induction.

UR - http://www.scopus.com/inward/record.url?scp=0027167738&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027167738&partnerID=8YFLogxK

U2 - 10.1080/07420529309059695

DO - 10.1080/07420529309059695

M3 - Article

VL - 10

SP - 81

EP - 86

JO - Annual Review of Chronopharmacology

JF - Annual Review of Chronopharmacology

SN - 0743-9539

IS - 2

ER -