Circadian variability of body temperature responses to methamphetamine

Abolhassan Behrouzvaziri, Maria V. Zaretskaia, Daniel Rusyniak, Dmitry Zaretsky, Yaroslav I. Molkov

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Vital parameters of living organisms exhibit circadian rhythmicity. Although rats are nocturnal animals, most of the studies involving rats are performed during the day. The objective of this study was to examine the circadian variability of the body temperature responses to methamphetamine. Body temperature was recorded in male Sprague-Dawley rats that received intraperitoneal injections of methamphetamine (Meth, 1 or 5 mg/kg) or saline at 10 AM or at 10 PM. The baseline body temperature at night was 0.8°C higher than during the day. Both during the day and at night, 1 mg/kg of Meth induced monophasic hyperthermia. However, the maximal temperature increase at night was 50% smaller than during the daytime. Injection of 5 mg/kg of Meth during the daytime caused a delayed hyperthermic response. In contrast, the same dose at night produced responses with a tendency toward a decrease of body temperature. Using mathematical modeling, we previously showed that the complex dose dependence of the daytime temperature responses to Meth results from an interplay between inhibitory and excitatory drives. In this study, using our model, we explain the suppression of the hyperthermia in response to Meth at night. First, we found that the baseline activity of the excitatory drive is greater at night. It appears partially saturated and thus is additionally activated by Meth to a lesser extent. Therefore, the excitatory component causes less hyperthermia or becomes overpowered by the inhibitory drive in response to the higher dose. Second, at night the injection of Meth results in reduction of the equilibrium body temperature, leading to gradual cooling counteracting hyperthermia.

Original languageEnglish (US)
Pages (from-to)R43-R48
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume314
Issue number1
DOIs
StatePublished - Jan 1 2018

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Methamphetamine
Body Temperature
Fever
Induced Hyperthermia
Injections
Temperature
Periodicity
Intraperitoneal Injections
Sprague Dawley Rats

Keywords

  • Body temperature
  • Circadian
  • Methamphetamine
  • Modeling

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Circadian variability of body temperature responses to methamphetamine. / Behrouzvaziri, Abolhassan; Zaretskaia, Maria V.; Rusyniak, Daniel; Zaretsky, Dmitry; Molkov, Yaroslav I.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 314, No. 1, 01.01.2018, p. R43-R48.

Research output: Contribution to journalArticle

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