Circadian variation of gastroesophageal reflux in children

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Asymptomatic infants and infants with gastroesophageal reflux have been noted to have peak reflux in the midafternoon. The aim of this study was to examine circadian variation of gastroesophageal reflux in children with both normal and abnormal 24-hr esophageal pH probe studies. Eighty-seven patients were studied and 15 of these patients were found to have a reflux index >4% for the duration of the study. These 15 patients were found to have significant circadian variation. Peak reflux indices (mean 12.60%) were detected in the mid-afternoon, with a smaller peak at night (mean 8.07%). Trough indices (mean 2.60%) occurred in the early morning. The 72 patients with normal studies were found to have less circadian variation, although peak reflux indices (mean 1.76%) occurred in the early morning. Clinicians should target their antireflux therapy to periods of peak gastroesophageal reflux.

Original languageEnglish
Pages (from-to)1818-1822
Number of pages5
JournalDigestive Diseases and Sciences
Volume48
Issue number9
DOIs
StatePublished - Sep 1 2003

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Gastroesophageal Reflux
Therapeutics

Keywords

  • Circadian rhythm
  • Gastroesophageal reflux
  • Pediatrics

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Circadian variation of gastroesophageal reflux in children. / Steiner, Steven; Croffie, Joseph; Gupta, Sandeep; Pfefferkorn, Marian; Fitzgerald, Joseph F.

In: Digestive Diseases and Sciences, Vol. 48, No. 9, 01.09.2003, p. 1818-1822.

Research output: Contribution to journalArticle

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