Circulating and Tissue Resident Endothelial Progenitor Cells

Research output: Contribution to journalArticlepeer-review

137 Scopus citations


Progenitor cells for the endothelial lineage have been widely investigated for more than a decade, but continue to be controversial since no unique identifying marker has yet been identified. This review will begin with a discussion of the basic tenets originally proposed for proof that a cell displays properties of an endothelial progenitor cell. We then provide an overview of the methods for putative endothelial progenitor cell derivation, expansion, and enumeration. This discussion includes consideration of cells that are present in the circulation as well as cells resident in the vascular endothelial intima. Finally, we provide some suggested changes in nomenclature that would greatly clarify and demystify the cellular elements involved in vascular repair.

Original languageEnglish (US)
Pages (from-to)10-16
Number of pages7
JournalJournal of cellular physiology
Issue number1
StatePublished - Jan 1 2014

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cell Biology

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