Circulating concentrations of biomarkers and metabolites related to Vitamin status, one-carbon and the kynurenine pathways in US, Nordic, Asian, and Australian populations

Øivind Midttun, Despoina Theofylaktopoulou, Adrian McCann, Anouar Fanidi, David C. Muller, Klaus Meyer, Arve Ulvik, Wei Zheng, Xiao Ou Shu, Yong Bing Xiang, Ross Prentice, Cynthia A. Thomson, Mary Pettinger, Graham G. Giles, Allison Hodge, Qiuyin Cai, William J. Blot, Jie Wu, Mikael Johansson, Johan Hultdin & 34 others Kjell Grankvist, Victoria L. Stevens, Marjorie L. McCullough, Stephanie J. Weinstein, Demetrius Albanes, Arnulf Langhammer, Kristian Hveem, Marit Næss, Howard D. Sesso, J. Michael Gaziano, Julie E. Buring, I. Min Lee, Gianluca Severi, Xuehong Zhang, Jiali Han, Meir J. Stampfer, Stephanie A. Smith-Warner, Anne Zeleniuch-Jacquotte, Loic Le Marchand, Jian Min Yuan, Lesley M. Butler, Woon Puay Koh, Renwei Wang, Yu Tang Gao, Ulrika Ericson, Emily Sonestedt, Regina G. Ziegler, Neal D. Freedman, Kala Visvanathan, Miranda R. Jones, Caroline Relton, Paul Brennan, Mattias Johansson, Per M. Ueland

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Circulating concentrations of biomarkers that are related to Vitamin status vary by factors such as diet, fortification, and supplement use. Published biomarker concentrations have also been influenced by the variation across laboratories, which complicates a comparison of results from different studies. Objective: We robustly and comprehensively assessed differences in biomarkers that are related to Vitamin status across geographic regions. Design: The trial was a cross-sectional study in which we investigated 38 biomarkers that are related to Vitamin status and one-carbon and tryptophan metabolism in serum and plasma from 5314 healthy control subjects representing 20 cohorts recruited from the United States, Nordic countries, Asia, and Australia, participating in the Lung Cancer Cohort Consortium. All samples were analyzed in a centralized laboratory. Results: Circulating concentrations of riboflavin, pyridoxal 5≤-phosphate, folate, Vitamin B-12, all-trans retinol, 25-hydroxyVitamin D, and a-tocopherol as well as combined Vitamin scores that were based on these nutrients showed that the general B-Vitamin concentration was highest in the United States and that the B Vitamins and lipid soluble Vitamins were low in Asians. Conversely, circulating concentrations of metabolites that are inversely related to B Vitamins involved in the one-carbon and kynurenine pathways were high in Asians. The high B-Vitamin concentration in the United States appears to be driven mainly by multiVitamin-supplement users. Conclusions: The observed differences likely reflect the variation in intake of Vitamins and, in particular, the widespread multiVitamin-supplement use in the United States. The results provide valuable information about the differences in biomarkerconcentrations in populations across continents. Am J Clin Nutr 2017;105:1314-26.

Original languageEnglish (US)
Pages (from-to)1314-1326
Number of pages13
JournalAmerican Journal of Clinical Nutrition
Volume105
Issue number6
DOIs
StatePublished - Jun 1 2017
Externally publishedYes

Fingerprint

Kynurenine
Vitamins
Vitamin B Complex
Carbon
Biomarkers
Population
Scandinavian and Nordic Countries
Flavin Mononucleotide
Pyridoxal Phosphate
Tocopherols
Vitamin B 12
Vitamin A
Folic Acid
Tryptophan
Lung Neoplasms
Healthy Volunteers
Cross-Sectional Studies
Diet
Lipids
Food

Keywords

  • Biomarker
  • Lung Cancer Cohort Consortium
  • One-carbon metabolism
  • Tryptophan metabolism
  • Vitamin status

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Circulating concentrations of biomarkers and metabolites related to Vitamin status, one-carbon and the kynurenine pathways in US, Nordic, Asian, and Australian populations. / Midttun, Øivind; Theofylaktopoulou, Despoina; McCann, Adrian; Fanidi, Anouar; Muller, David C.; Meyer, Klaus; Ulvik, Arve; Zheng, Wei; Shu, Xiao Ou; Xiang, Yong Bing; Prentice, Ross; Thomson, Cynthia A.; Pettinger, Mary; Giles, Graham G.; Hodge, Allison; Cai, Qiuyin; Blot, William J.; Wu, Jie; Johansson, Mikael; Hultdin, Johan; Grankvist, Kjell; Stevens, Victoria L.; McCullough, Marjorie L.; Weinstein, Stephanie J.; Albanes, Demetrius; Langhammer, Arnulf; Hveem, Kristian; Næss, Marit; Sesso, Howard D.; Gaziano, J. Michael; Buring, Julie E.; Lee, I. Min; Severi, Gianluca; Zhang, Xuehong; Han, Jiali; Stampfer, Meir J.; Smith-Warner, Stephanie A.; Zeleniuch-Jacquotte, Anne; Le Marchand, Loic; Yuan, Jian Min; Butler, Lesley M.; Koh, Woon Puay; Wang, Renwei; Gao, Yu Tang; Ericson, Ulrika; Sonestedt, Emily; Ziegler, Regina G.; Freedman, Neal D.; Visvanathan, Kala; Jones, Miranda R.; Relton, Caroline; Brennan, Paul; Johansson, Mattias; Ueland, Per M.

In: American Journal of Clinical Nutrition, Vol. 105, No. 6, 01.06.2017, p. 1314-1326.

Research output: Contribution to journalArticle

Midttun, Ø, Theofylaktopoulou, D, McCann, A, Fanidi, A, Muller, DC, Meyer, K, Ulvik, A, Zheng, W, Shu, XO, Xiang, YB, Prentice, R, Thomson, CA, Pettinger, M, Giles, GG, Hodge, A, Cai, Q, Blot, WJ, Wu, J, Johansson, M, Hultdin, J, Grankvist, K, Stevens, VL, McCullough, ML, Weinstein, SJ, Albanes, D, Langhammer, A, Hveem, K, Næss, M, Sesso, HD, Gaziano, JM, Buring, JE, Lee, IM, Severi, G, Zhang, X, Han, J, Stampfer, MJ, Smith-Warner, SA, Zeleniuch-Jacquotte, A, Le Marchand, L, Yuan, JM, Butler, LM, Koh, WP, Wang, R, Gao, YT, Ericson, U, Sonestedt, E, Ziegler, RG, Freedman, ND, Visvanathan, K, Jones, MR, Relton, C, Brennan, P, Johansson, M & Ueland, PM 2017, 'Circulating concentrations of biomarkers and metabolites related to Vitamin status, one-carbon and the kynurenine pathways in US, Nordic, Asian, and Australian populations', American Journal of Clinical Nutrition, vol. 105, no. 6, pp. 1314-1326. https://doi.org/10.3945/ajcn.116.151241
Midttun, Øivind ; Theofylaktopoulou, Despoina ; McCann, Adrian ; Fanidi, Anouar ; Muller, David C. ; Meyer, Klaus ; Ulvik, Arve ; Zheng, Wei ; Shu, Xiao Ou ; Xiang, Yong Bing ; Prentice, Ross ; Thomson, Cynthia A. ; Pettinger, Mary ; Giles, Graham G. ; Hodge, Allison ; Cai, Qiuyin ; Blot, William J. ; Wu, Jie ; Johansson, Mikael ; Hultdin, Johan ; Grankvist, Kjell ; Stevens, Victoria L. ; McCullough, Marjorie L. ; Weinstein, Stephanie J. ; Albanes, Demetrius ; Langhammer, Arnulf ; Hveem, Kristian ; Næss, Marit ; Sesso, Howard D. ; Gaziano, J. Michael ; Buring, Julie E. ; Lee, I. Min ; Severi, Gianluca ; Zhang, Xuehong ; Han, Jiali ; Stampfer, Meir J. ; Smith-Warner, Stephanie A. ; Zeleniuch-Jacquotte, Anne ; Le Marchand, Loic ; Yuan, Jian Min ; Butler, Lesley M. ; Koh, Woon Puay ; Wang, Renwei ; Gao, Yu Tang ; Ericson, Ulrika ; Sonestedt, Emily ; Ziegler, Regina G. ; Freedman, Neal D. ; Visvanathan, Kala ; Jones, Miranda R. ; Relton, Caroline ; Brennan, Paul ; Johansson, Mattias ; Ueland, Per M. / Circulating concentrations of biomarkers and metabolites related to Vitamin status, one-carbon and the kynurenine pathways in US, Nordic, Asian, and Australian populations. In: American Journal of Clinical Nutrition. 2017 ; Vol. 105, No. 6. pp. 1314-1326.
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abstract = "Background: Circulating concentrations of biomarkers that are related to Vitamin status vary by factors such as diet, fortification, and supplement use. Published biomarker concentrations have also been influenced by the variation across laboratories, which complicates a comparison of results from different studies. Objective: We robustly and comprehensively assessed differences in biomarkers that are related to Vitamin status across geographic regions. Design: The trial was a cross-sectional study in which we investigated 38 biomarkers that are related to Vitamin status and one-carbon and tryptophan metabolism in serum and plasma from 5314 healthy control subjects representing 20 cohorts recruited from the United States, Nordic countries, Asia, and Australia, participating in the Lung Cancer Cohort Consortium. All samples were analyzed in a centralized laboratory. Results: Circulating concentrations of riboflavin, pyridoxal 5≤-phosphate, folate, Vitamin B-12, all-trans retinol, 25-hydroxyVitamin D, and a-tocopherol as well as combined Vitamin scores that were based on these nutrients showed that the general B-Vitamin concentration was highest in the United States and that the B Vitamins and lipid soluble Vitamins were low in Asians. Conversely, circulating concentrations of metabolites that are inversely related to B Vitamins involved in the one-carbon and kynurenine pathways were high in Asians. The high B-Vitamin concentration in the United States appears to be driven mainly by multiVitamin-supplement users. Conclusions: The observed differences likely reflect the variation in intake of Vitamins and, in particular, the widespread multiVitamin-supplement use in the United States. The results provide valuable information about the differences in biomarkerconcentrations in populations across continents. Am J Clin Nutr 2017;105:1314-26.",
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TY - JOUR

T1 - Circulating concentrations of biomarkers and metabolites related to Vitamin status, one-carbon and the kynurenine pathways in US, Nordic, Asian, and Australian populations

AU - Midttun, Øivind

AU - Theofylaktopoulou, Despoina

AU - McCann, Adrian

AU - Fanidi, Anouar

AU - Muller, David C.

AU - Meyer, Klaus

AU - Ulvik, Arve

AU - Zheng, Wei

AU - Shu, Xiao Ou

AU - Xiang, Yong Bing

AU - Prentice, Ross

AU - Thomson, Cynthia A.

AU - Pettinger, Mary

AU - Giles, Graham G.

AU - Hodge, Allison

AU - Cai, Qiuyin

AU - Blot, William J.

AU - Wu, Jie

AU - Johansson, Mikael

AU - Hultdin, Johan

AU - Grankvist, Kjell

AU - Stevens, Victoria L.

AU - McCullough, Marjorie L.

AU - Weinstein, Stephanie J.

AU - Albanes, Demetrius

AU - Langhammer, Arnulf

AU - Hveem, Kristian

AU - Næss, Marit

AU - Sesso, Howard D.

AU - Gaziano, J. Michael

AU - Buring, Julie E.

AU - Lee, I. Min

AU - Severi, Gianluca

AU - Zhang, Xuehong

AU - Han, Jiali

AU - Stampfer, Meir J.

AU - Smith-Warner, Stephanie A.

AU - Zeleniuch-Jacquotte, Anne

AU - Le Marchand, Loic

AU - Yuan, Jian Min

AU - Butler, Lesley M.

AU - Koh, Woon Puay

AU - Wang, Renwei

AU - Gao, Yu Tang

AU - Ericson, Ulrika

AU - Sonestedt, Emily

AU - Ziegler, Regina G.

AU - Freedman, Neal D.

AU - Visvanathan, Kala

AU - Jones, Miranda R.

AU - Relton, Caroline

AU - Brennan, Paul

AU - Johansson, Mattias

AU - Ueland, Per M.

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Background: Circulating concentrations of biomarkers that are related to Vitamin status vary by factors such as diet, fortification, and supplement use. Published biomarker concentrations have also been influenced by the variation across laboratories, which complicates a comparison of results from different studies. Objective: We robustly and comprehensively assessed differences in biomarkers that are related to Vitamin status across geographic regions. Design: The trial was a cross-sectional study in which we investigated 38 biomarkers that are related to Vitamin status and one-carbon and tryptophan metabolism in serum and plasma from 5314 healthy control subjects representing 20 cohorts recruited from the United States, Nordic countries, Asia, and Australia, participating in the Lung Cancer Cohort Consortium. All samples were analyzed in a centralized laboratory. Results: Circulating concentrations of riboflavin, pyridoxal 5≤-phosphate, folate, Vitamin B-12, all-trans retinol, 25-hydroxyVitamin D, and a-tocopherol as well as combined Vitamin scores that were based on these nutrients showed that the general B-Vitamin concentration was highest in the United States and that the B Vitamins and lipid soluble Vitamins were low in Asians. Conversely, circulating concentrations of metabolites that are inversely related to B Vitamins involved in the one-carbon and kynurenine pathways were high in Asians. The high B-Vitamin concentration in the United States appears to be driven mainly by multiVitamin-supplement users. Conclusions: The observed differences likely reflect the variation in intake of Vitamins and, in particular, the widespread multiVitamin-supplement use in the United States. The results provide valuable information about the differences in biomarkerconcentrations in populations across continents. Am J Clin Nutr 2017;105:1314-26.

AB - Background: Circulating concentrations of biomarkers that are related to Vitamin status vary by factors such as diet, fortification, and supplement use. Published biomarker concentrations have also been influenced by the variation across laboratories, which complicates a comparison of results from different studies. Objective: We robustly and comprehensively assessed differences in biomarkers that are related to Vitamin status across geographic regions. Design: The trial was a cross-sectional study in which we investigated 38 biomarkers that are related to Vitamin status and one-carbon and tryptophan metabolism in serum and plasma from 5314 healthy control subjects representing 20 cohorts recruited from the United States, Nordic countries, Asia, and Australia, participating in the Lung Cancer Cohort Consortium. All samples were analyzed in a centralized laboratory. Results: Circulating concentrations of riboflavin, pyridoxal 5≤-phosphate, folate, Vitamin B-12, all-trans retinol, 25-hydroxyVitamin D, and a-tocopherol as well as combined Vitamin scores that were based on these nutrients showed that the general B-Vitamin concentration was highest in the United States and that the B Vitamins and lipid soluble Vitamins were low in Asians. Conversely, circulating concentrations of metabolites that are inversely related to B Vitamins involved in the one-carbon and kynurenine pathways were high in Asians. The high B-Vitamin concentration in the United States appears to be driven mainly by multiVitamin-supplement users. Conclusions: The observed differences likely reflect the variation in intake of Vitamins and, in particular, the widespread multiVitamin-supplement use in the United States. The results provide valuable information about the differences in biomarkerconcentrations in populations across continents. Am J Clin Nutr 2017;105:1314-26.

KW - Biomarker

KW - Lung Cancer Cohort Consortium

KW - One-carbon metabolism

KW - Tryptophan metabolism

KW - Vitamin status

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