Circulating levels of resistin and risk of type 2 diabetes in men and women: Results from two prospective cohorts

Brian H. Chen, Yiqing Song, Eric L. Ding, Christian K. Roberts, Joann E. Manson, Nader Rifai, Julie E. Buring, J. Michael Gaziano, Simin Liu

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Abstract

OBJECTIVE - The purpose of this study was to investigate the role of circulating resistin levels in the development of type 2 diabetes using two prospective cohorts of well-characterized men and women. RESEARCH DESIGN AND METHODS - We conducted two prospective case-control studies nested in the Women's Health Study (WHS) and Physicians' Health Study II (PHS II). In the WHS, during a median of 10-years of follow-up, 359 postmenopausal women, who were apparently healthy at baseline and later developed type 2 diabetes, were prospectively matched with 359 healthy control subjects. In the PHS II, with 8 years of total follow-up, 170 men, who were apparently healthy at baseline and later developed type 2 diabetes, were matched with 170 healthy control subjects. Control subjects were matched by age, race, and time of blood draw. RESULTS - Resistin levels at baseline were significantly higher in women than in men (P = 0.003) and in case patients than in control subjects for both women (P < 0.001) and men (P = 0.07). After adjustment for matching factors, physical activity, alcohol intake, smoking, and family history of diabetes, the relative risk of type 2 diabetes comparing the highest to the lowest quartile of resistin in women was 2.22 ([95% CI 1.32-3.73]; P trend = 0.002). This association was attenuated after further adjustment for BMI (1.51 [0.86-2.65]; P trend = 0.20) or C-reactive protein (1.18 [0.68-2.07]; P trend = 0.60). A similar but weaker pattern was observed in men. CONCLUSIONS - Elevated levels of circulating resistin were significantly related to increased risk of type 2 diabetes, which appears to be partially accounted for by adiposity and the inflammatory process.

Original languageEnglish (US)
Pages (from-to)329-334
Number of pages6
JournalDiabetes care
Volume32
Issue number2
DOIs
StatePublished - Feb 1 2009

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ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

Cite this

Chen, B. H., Song, Y., Ding, E. L., Roberts, C. K., Manson, J. E., Rifai, N., Buring, J. E., Gaziano, J. M., & Liu, S. (2009). Circulating levels of resistin and risk of type 2 diabetes in men and women: Results from two prospective cohorts. Diabetes care, 32(2), 329-334. https://doi.org/10.2337/dc08-1625