Circulating Th1-Cell-type Tfh Cells that Exhibit Impaired B Cell Help Are Preferentially Activated during Acute Malaria in Children

Nyamekye Obeng-Adjei, Silvia Portugal, Tuan M. Tran, Takele B. Yazew, Jeff Skinner, Shanping Li, Aarti Jain, Philip L. Felgner, Ogobara K. Doumbo, Kassoum Kayentao, Aissata Ongoiba, Boubacar Traore, Peter D. Crompton

Research output: Contribution to journalArticle

87 Scopus citations

Abstract

Malaria-specific antibody responses are short lived in children, leaving them susceptible to repeated bouts of febrile malaria. The cellular and molecular mechanisms underlying this apparent immune deficiency are poorly understood. Recently, T follicular helper (Tfh) cells have been shown to play a critical role in generating long-lived antibody responses. We show that Malian children have resting PD-1+CXCR5+CD4+ Tfh cells in circulation that resemble germinal center Tfh cells phenotypically and functionally. Within this population, PD-1+CXCR5+CXCR3- Tfh cells are superior to Th1-polarized PD-1+CXCR5+CXCR3+ Tfh cells in helping B cells. Longitudinally, we observed that malaria drives Th1 cytokine responses, and accordingly, the less-functional Th1-polarized Tfh subset was preferentially activated and its activation did not correlate with antibody responses. These data provide insights into the Tfh cell biology underlying suboptimal antibody responses to malaria in children and suggest that vaccine strategies that promote CXCR3- Tfh cell responses may improve malaria vaccine efficacy.

Original languageEnglish (US)
Pages (from-to)425-439
Number of pages15
JournalCell Reports
Volume13
Issue number2
DOIs
StatePublished - Oct 13 2015

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Obeng-Adjei, N., Portugal, S., Tran, T. M., Yazew, T. B., Skinner, J., Li, S., Jain, A., Felgner, P. L., Doumbo, O. K., Kayentao, K., Ongoiba, A., Traore, B., & Crompton, P. D. (2015). Circulating Th1-Cell-type Tfh Cells that Exhibit Impaired B Cell Help Are Preferentially Activated during Acute Malaria in Children. Cell Reports, 13(2), 425-439. https://doi.org/10.1016/j.celrep.2015.09.004