Circulating Thrombospondin-2 enhances prediction of malignant intraductal papillary mucinous neoplasm

Rachel E. Simpson, Michele T. Yip-Schneider, Huangbing Wu, Hao Fan, Ziyue Liu, Murray Korc, Jianjun Zhang, C. Max Schmidt

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Background: IPMNs are cystic pancreatic lesions with variable malignant potential. Thrombospondin-2 (THBS2)—an endogenous, anti-angiogenic matrix glycoprotein—may modulate tumor progression. We hypothesized that circulating levels of THBS2 could aid in preoperative prediction of malignant IPMN. Methods: Preoperative serum/plasma samples were procured from patients undergoing surgery. Circulating levels of THBS2 were measured (enzyme-linked immunosorbent assay) and compared to surgical pathology IPMN dysplastic grade. Results: 164 patients underwent THBS2 testing (100 Low/Moderate-IPMN; 64 High-Grade/Invasive-IPMN). Circulating THBS2 (mean ± SD) was greater in High-Grade/Invasive-IPMN than Low/Moderate-grade IPMN (26.6 ± 12.7 ng/mL vs. 20.4 ± 8.2 ng/mL; P < 0.001). THBS2 (AUC = 0.65) out-performed CA19-9 (n = 144; AUC = 0.59) in predicting IPMN grade. The combination of THBS2, CA19-9, radiographic main-duct involvement, main-duct diameter, age, sex, and BMI (AUC 0.82; n = 137) provided a good prediction model for IPMN grade. Conclusion: Circulating THBS2 is correlated with IPMN dysplasia grade. THBS2 alone did not strongly predict IPMN grade but rather strengthened prediction models for High-Grade/Invasive IPMN when combined with other clinical/biomarker data.

Original languageEnglish (US)
Pages (from-to)425-428
Number of pages4
JournalAmerican Journal of Surgery
Volume217
Issue number3
DOIs
StatePublished - Mar 2019

Keywords

  • Biomarker
  • IPMN
  • Intraductal papillary mucinous neoplasm
  • Pancreatic cancer
  • Pancreatic cyst
  • Thrombospondin-2

ASJC Scopus subject areas

  • Surgery

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