Circulating tumor cells: A reliable biomarker for prostate cancer treatment assessment?

Chiara Ciccarese, Rodolfo Montironi, Michelangelo Fiorentino, Guido Martignoni, Matteo Brunelli, Roberto Iacovelli, Antonio Lopez-Beltranf, Liang Cheng, Marina Scarpelli, Holger Moch, Giampaolo Tortora, Francesco Massari

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

Background: Prostate cancer is a common malignancy with highly molecular heterogeneity responsible for a wide spectrum of clinical behavior. To date, several treatment options are available, whose selection is currently based mainly on clinical criteria. Given the weakness of conventional imaging and PSA assay, the identification of a prognostic and predictive biomarker for choosing the appropriate treatment and monitoring its efficacy is a very topical issue in prostate cancer management. Circulating tumor cells (CTCs) have substantial promise for early tumor diagnosis, disease recurrence and metastatic spread monitoring as well as for biological tumor characterization, thus representing a reliable translational real-Time biomarkers of prostate cancer. Conclusion: This paper summarized the main data available about CTCs detection, their prognostic value, and their potential predictive role for metastatic prostate cancer patients management.

Original languageEnglish (US)
Pages (from-to)692-699
Number of pages8
JournalCurrent Drug Metabolism
Volume18
Issue number8
DOIs
StatePublished - Jan 1 2017

Keywords

  • Biomarker
  • Circulating tumor cells
  • CTCs
  • Malignancy
  • MCRPC
  • Prostate cancer

ASJC Scopus subject areas

  • Pharmacology
  • Clinical Biochemistry

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  • Cite this

    Ciccarese, C., Montironi, R., Fiorentino, M., Martignoni, G., Brunelli, M., Iacovelli, R., Lopez-Beltranf, A., Cheng, L., Scarpelli, M., Moch, H., Tortora, G., & Massari, F. (2017). Circulating tumor cells: A reliable biomarker for prostate cancer treatment assessment? Current Drug Metabolism, 18(8), 692-699. https://doi.org/10.2174/1389200218666170518163549