Cis-diamminedichloroplatinum, vinblastine, and bleomycin combination chemotherapy in disseminated testicular cancer

L. H. Einhorn, J. Donohue

Research output: Contribution to journalArticle

1208 Scopus citations

Abstract

Fifty patients with disseminated testicular cancer were treated with a three-drug combination consisting of cis-diamminedichloroplatinum, vinblastine, and bleomycin. Three patients were considered inevaluable due to early death. This chemotherapy regimen produced 74% complete and 26% partial remissions. Furthermore, five patients with partial remission became disease-free after surgical removal of residual disease, producing an overall 85% disease-free status. Toxicity, although significant during remission induction with cis-platinum, vinblastine, and bleomycin, was usually manageable, although there were two drug-related deaths during this period. Thirty-eight of these patients remain alive and 32 remain alive and disease-free at 6+ to 30+ months. We believe this regimen represents a major advance in the management of patients with disseminated testicular cancer.

Original languageEnglish (US)
Pages (from-to)293-298
Number of pages6
JournalAnnals of internal medicine
Volume87
Issue number3
DOIs
StatePublished - Jan 1 1977

ASJC Scopus subject areas

  • Internal Medicine

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