Eighteen patients with advanced gynecologic malignancies received cis-diamminedichloroplatinum (NSC 119875), an inorganic heavy metal compound with antineoplastic properties. Twelve patients had carcinoma of the ovary resistant to other chemotherapeutic agents. Three patients had previously irradiated carcinoma of the cervix; two, disseminated pelvic sarcoma; and one, metastatic carcinoma of the vulva. Objective responses were achieved in four patients (25%) with carcinoma of the ovary. Three patients with other tumors also responded. Mild to severe myelosuppression, nephrotoxicity, and ototoxicity occurred.
ASJC Scopus subject areas
- Obstetrics and Gynecology