Cisplatin

Research output: Contribution to journalArticle

1047 Scopus citations

Abstract

Cisplatin is a metal coordination compound that was approved for clinical use in treating testicular cancer 5 years ago. Although early trials showed marked gastrointestinal and renal toxicities, treatment-related morbidity has been significantly alleviated with modern antiemetic therapy and adequate pretreatment hydration. More recent clinical studies of cisplatin have shown a broad range of activity and provide a better understanding of the drug's pharmacology, mechanism of action, and toxicity. Variations in the dosage and mode of administration as well as development of cisplatin analogues are being currently studied.

Original languageEnglish (US)
Pages (from-to)704-713
Number of pages10
JournalAnnals of internal medicine
Volume100
Issue number5
DOIs
StatePublished - 1984

ASJC Scopus subject areas

  • Internal Medicine

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