Cisplatin ototoxicity affecting cochlear implant benefit

Michael S. Harris, Jaimie L. Gilbert, Kelly A. Lormore, Swapna A. Musunuru, Michael H. Fritsch

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: Report a case of loss of cochlear implant benefit after cisplatin therapy to treat osteosarcoma. Examine the implications for the loci of cisplatin-associated cochleotoxicity. Study Design: Retrospective case review. Setting: Tertiary referral center. Patients: Single case study. Intervention(s): None. Main Outcome Measure(s): Cochlear implant programming levels. Results: Increase in cochlear implant programming T- and C-levels after cisplatin therapy. Conclusion: Cisplatin therapy likely affects spiral ganglion cells. It seems that auditory cells other than outer hair cells in the organ of Corti are affected by cisplatin because the hearing sensitivity of this patient with nonfunctioning outer hair cells declined after receiving chemotherapy. Implications of these findings are discussed.

Original languageEnglish
Pages (from-to)969-972
Number of pages4
JournalOtology and Neurotology
Volume32
Issue number6
DOIs
StatePublished - Aug 2011

Fingerprint

Cochlear Implants
Cisplatin
Outer Auditory Hair Cells
Spiral Ganglion
Organ of Corti
Osteosarcoma
Tertiary Care Centers
Hearing
Therapeutics
Retrospective Studies
Outcome Assessment (Health Care)
Drug Therapy

Keywords

  • Cisplatin
  • Cochlear implant
  • Ototoxicity
  • Spiral ganglion cells

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Clinical Neurology
  • Sensory Systems
  • Medicine(all)

Cite this

Harris, M. S., Gilbert, J. L., Lormore, K. A., Musunuru, S. A., & Fritsch, M. H. (2011). Cisplatin ototoxicity affecting cochlear implant benefit. Otology and Neurotology, 32(6), 969-972. https://doi.org/10.1097/MAO.0b013e3182255893

Cisplatin ototoxicity affecting cochlear implant benefit. / Harris, Michael S.; Gilbert, Jaimie L.; Lormore, Kelly A.; Musunuru, Swapna A.; Fritsch, Michael H.

In: Otology and Neurotology, Vol. 32, No. 6, 08.2011, p. 969-972.

Research output: Contribution to journalArticle

Harris, MS, Gilbert, JL, Lormore, KA, Musunuru, SA & Fritsch, MH 2011, 'Cisplatin ototoxicity affecting cochlear implant benefit', Otology and Neurotology, vol. 32, no. 6, pp. 969-972. https://doi.org/10.1097/MAO.0b013e3182255893
Harris MS, Gilbert JL, Lormore KA, Musunuru SA, Fritsch MH. Cisplatin ototoxicity affecting cochlear implant benefit. Otology and Neurotology. 2011 Aug;32(6):969-972. https://doi.org/10.1097/MAO.0b013e3182255893
Harris, Michael S. ; Gilbert, Jaimie L. ; Lormore, Kelly A. ; Musunuru, Swapna A. ; Fritsch, Michael H. / Cisplatin ototoxicity affecting cochlear implant benefit. In: Otology and Neurotology. 2011 ; Vol. 32, No. 6. pp. 969-972.
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