Clinical and epidemiological characterization of histoplasmosis cases in a nonendemic area, Connecticut, United States

Marwan M. Azar, Xuchen Zhang, Roland Assi, Chadi Hage, L. Joseph Wheat, Maricar F. Malinis

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

We performed a retrospective analysis of histoplasmosis cases diagnosed at our institution in New Haven, Connecticut, from 2005 to 2015. Among 12 cases of active histoplasmosis, seven were immunosuppressed and five had human immunodeficiency virus (HIV). Eleven patients reported travel to potentially endemic areas at a median of 105 days prior to presentation; travel to the Caribbean was most common (n = 6). Median time to diagnosis from symptom onset and first Histoplasma antigen testing were 41 and 28 days, respectively. Consistent with reports from other non-endemic areas, our findings suggest that the epidemiology of histoplasmosis may differ in Connecticut, potentially contributing to delayed diagnoses.

Original languageEnglish (US)
Pages (from-to)896-899
Number of pages4
JournalMedical Mycology
Volume56
Issue number7
DOIs
StatePublished - Oct 1 2018

Keywords

  • delay
  • epidemiology
  • histoplasmosis
  • nonendemic
  • travel

ASJC Scopus subject areas

  • Infectious Diseases

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