Clinical and nutritional correlates of C-reactive protein in type 2 diabetic nephropathy

Allon Friedman, Lawrence G. Hunsicker, Jacob Selhub, Andrew G. Bostom

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: Patients with diabetic nephropathy are at elevated cardiovascular risk. C-reactive protein (CRP) has been used to successfully predict cardiovascular events. Objective: We identified clinical and biochemical characteristics that correlate with CRP levels in diabetic nephropathy patients. Design: Baseline data obtained from 722 patients in the Irbesartan Diabetic Nephropathy Trial included age, sex, body mass index (BMI), systolic blood pressure (BP), serum creatinine, plasma low- and high-density cholesterol, triacylglycerol, serum albumin, hemoglobin A1C, 24h urinary protein excretion, plasma total homocysteine (tHcy), folate, B12, pyridoxal 5′-phosphate (PLP, active form of Vitamin B6), and plasma CRP levels. Results: In univariate analyses CRP was positively associated with female sex (r=0.08; P=0.04), BMI (r=0.34; P<0.01), serum creatinine (r=0.21; P<0.01), hemoglobin A1C (r=0.08; 0.04), and inversely associated with PLP (r=-0.17; P<0.01) and folate (r=-0.09; P=0.02). A stepwise multiple regression model found CRP directly correlated with BMI (P<0.01) and serum creatinine (P<0.01), and inversely correlated with PLP (P<0.01). The final model explained 16% of the total variance of CRP. Conclusions: These results extend previous findings of an inverse relationship between Vitamin B6 and CRP. The lack of association between CRP and certain established or emerging cardiovascular risk factors offers novel information regarding cardiovascular risk in this population.

Original languageEnglish
Pages (from-to)121-125
Number of pages5
JournalAtherosclerosis
Volume172
Issue number1
DOIs
StatePublished - Jan 2004

Fingerprint

Diabetic Nephropathies
C-Reactive Protein
Creatinine
Body Mass Index
Vitamin B 6
irbesartan
Folic Acid
Blood Proteins
Hemoglobins
Serum
Blood Pressure
Pyridoxal Phosphate
Homocysteine
Serum Albumin
Ascorbic Acid
Triglycerides
Cholesterol
Population

Keywords

  • Body mass index
  • C-reactive protein
  • Cardiovascular
  • Creatinine
  • Diabetes
  • Pyridoxal phosphate
  • Vitamin B

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Clinical and nutritional correlates of C-reactive protein in type 2 diabetic nephropathy. / Friedman, Allon; Hunsicker, Lawrence G.; Selhub, Jacob; Bostom, Andrew G.

In: Atherosclerosis, Vol. 172, No. 1, 01.2004, p. 121-125.

Research output: Contribution to journalArticle

Friedman, Allon ; Hunsicker, Lawrence G. ; Selhub, Jacob ; Bostom, Andrew G. / Clinical and nutritional correlates of C-reactive protein in type 2 diabetic nephropathy. In: Atherosclerosis. 2004 ; Vol. 172, No. 1. pp. 121-125.
@article{dcf15befdeee457db0a7ee40f9bf9586,
title = "Clinical and nutritional correlates of C-reactive protein in type 2 diabetic nephropathy",
abstract = "Background: Patients with diabetic nephropathy are at elevated cardiovascular risk. C-reactive protein (CRP) has been used to successfully predict cardiovascular events. Objective: We identified clinical and biochemical characteristics that correlate with CRP levels in diabetic nephropathy patients. Design: Baseline data obtained from 722 patients in the Irbesartan Diabetic Nephropathy Trial included age, sex, body mass index (BMI), systolic blood pressure (BP), serum creatinine, plasma low- and high-density cholesterol, triacylglycerol, serum albumin, hemoglobin A1C, 24h urinary protein excretion, plasma total homocysteine (tHcy), folate, B12, pyridoxal 5′-phosphate (PLP, active form of Vitamin B6), and plasma CRP levels. Results: In univariate analyses CRP was positively associated with female sex (r=0.08; P=0.04), BMI (r=0.34; P<0.01), serum creatinine (r=0.21; P<0.01), hemoglobin A1C (r=0.08; 0.04), and inversely associated with PLP (r=-0.17; P<0.01) and folate (r=-0.09; P=0.02). A stepwise multiple regression model found CRP directly correlated with BMI (P<0.01) and serum creatinine (P<0.01), and inversely correlated with PLP (P<0.01). The final model explained 16{\%} of the total variance of CRP. Conclusions: These results extend previous findings of an inverse relationship between Vitamin B6 and CRP. The lack of association between CRP and certain established or emerging cardiovascular risk factors offers novel information regarding cardiovascular risk in this population.",
keywords = "Body mass index, C-reactive protein, Cardiovascular, Creatinine, Diabetes, Pyridoxal phosphate, Vitamin B",
author = "Allon Friedman and Hunsicker, {Lawrence G.} and Jacob Selhub and Bostom, {Andrew G.}",
year = "2004",
month = "1",
doi = "10.1016/j.atherosclerosis.2003.09.011",
language = "English",
volume = "172",
pages = "121--125",
journal = "Atherosclerosis",
issn = "0021-9150",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Clinical and nutritional correlates of C-reactive protein in type 2 diabetic nephropathy

AU - Friedman, Allon

AU - Hunsicker, Lawrence G.

AU - Selhub, Jacob

AU - Bostom, Andrew G.

PY - 2004/1

Y1 - 2004/1

N2 - Background: Patients with diabetic nephropathy are at elevated cardiovascular risk. C-reactive protein (CRP) has been used to successfully predict cardiovascular events. Objective: We identified clinical and biochemical characteristics that correlate with CRP levels in diabetic nephropathy patients. Design: Baseline data obtained from 722 patients in the Irbesartan Diabetic Nephropathy Trial included age, sex, body mass index (BMI), systolic blood pressure (BP), serum creatinine, plasma low- and high-density cholesterol, triacylglycerol, serum albumin, hemoglobin A1C, 24h urinary protein excretion, plasma total homocysteine (tHcy), folate, B12, pyridoxal 5′-phosphate (PLP, active form of Vitamin B6), and plasma CRP levels. Results: In univariate analyses CRP was positively associated with female sex (r=0.08; P=0.04), BMI (r=0.34; P<0.01), serum creatinine (r=0.21; P<0.01), hemoglobin A1C (r=0.08; 0.04), and inversely associated with PLP (r=-0.17; P<0.01) and folate (r=-0.09; P=0.02). A stepwise multiple regression model found CRP directly correlated with BMI (P<0.01) and serum creatinine (P<0.01), and inversely correlated with PLP (P<0.01). The final model explained 16% of the total variance of CRP. Conclusions: These results extend previous findings of an inverse relationship between Vitamin B6 and CRP. The lack of association between CRP and certain established or emerging cardiovascular risk factors offers novel information regarding cardiovascular risk in this population.

AB - Background: Patients with diabetic nephropathy are at elevated cardiovascular risk. C-reactive protein (CRP) has been used to successfully predict cardiovascular events. Objective: We identified clinical and biochemical characteristics that correlate with CRP levels in diabetic nephropathy patients. Design: Baseline data obtained from 722 patients in the Irbesartan Diabetic Nephropathy Trial included age, sex, body mass index (BMI), systolic blood pressure (BP), serum creatinine, plasma low- and high-density cholesterol, triacylglycerol, serum albumin, hemoglobin A1C, 24h urinary protein excretion, plasma total homocysteine (tHcy), folate, B12, pyridoxal 5′-phosphate (PLP, active form of Vitamin B6), and plasma CRP levels. Results: In univariate analyses CRP was positively associated with female sex (r=0.08; P=0.04), BMI (r=0.34; P<0.01), serum creatinine (r=0.21; P<0.01), hemoglobin A1C (r=0.08; 0.04), and inversely associated with PLP (r=-0.17; P<0.01) and folate (r=-0.09; P=0.02). A stepwise multiple regression model found CRP directly correlated with BMI (P<0.01) and serum creatinine (P<0.01), and inversely correlated with PLP (P<0.01). The final model explained 16% of the total variance of CRP. Conclusions: These results extend previous findings of an inverse relationship between Vitamin B6 and CRP. The lack of association between CRP and certain established or emerging cardiovascular risk factors offers novel information regarding cardiovascular risk in this population.

KW - Body mass index

KW - C-reactive protein

KW - Cardiovascular

KW - Creatinine

KW - Diabetes

KW - Pyridoxal phosphate

KW - Vitamin B

UR - http://www.scopus.com/inward/record.url?scp=0346094370&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0346094370&partnerID=8YFLogxK

U2 - 10.1016/j.atherosclerosis.2003.09.011

DO - 10.1016/j.atherosclerosis.2003.09.011

M3 - Article

C2 - 14709365

AN - SCOPUS:0346094370

VL - 172

SP - 121

EP - 125

JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

IS - 1

ER -