Elimination of amitriptyline and/or metabolite after overdoses may be delayed because of impaired metabolism. A case is described where this was possibly related to hepatotoxicity. Metabolite concentrations, including 10-OH-derivatives, were highly elevated. The biological properties and clinical significance of these metabolites merit further study.
|Original language||English (US)|
|Number of pages||3|
|Journal||Journal of Clinical Psychopharmacology|
|State||Published - Jun 1984|
ASJC Scopus subject areas
- Psychiatry and Mental health
- Pharmacology (medical)