Clinical and pharmacological considerations in elimination of tricyclic antidepressants and metabolites after overdose

Wolfgang F. Kuhn, David R. Jones, Steven B. Lippmann, Charles K. Embry, Walter M. Williams, Manoochehr S. Manshadi, Harrell E. Hurst

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5 Scopus citations

Abstract

Elimination of amitriptyline and/or metabolite after overdoses may be delayed because of impaired metabolism. A case is described where this was possibly related to hepatotoxicity. Metabolite concentrations, including 10-OH-derivatives, were highly elevated. The biological properties and clinical significance of these metabolites merit further study.

Original languageEnglish (US)
Pages (from-to)158-160
Number of pages3
JournalJournal of Clinical Psychopharmacology
Volume4
Issue number3
StatePublished - Jun 1984

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ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

Kuhn, W. F., Jones, D. R., Lippmann, S. B., Embry, C. K., Williams, W. M., Manshadi, M. S., & Hurst, H. E. (1984). Clinical and pharmacological considerations in elimination of tricyclic antidepressants and metabolites after overdose. Journal of Clinical Psychopharmacology, 4(3), 158-160.