Clinical and pharmacological considerations in elimination of tricyclic antidepressants and metabolites after overdose

Wolfgang F. Kuhn, David R. Jones, Steven B. Lippmann, Charles K. Embry, Walter M. Williams, Manoochehr S. Manshadi, Harrell E. Hurst

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Elimination of amitriptyline and/or metabolite after overdoses may be delayed because of impaired metabolism. A case is described where this was possibly related to hepatotoxicity. Metabolite concentrations, including 10-OH-derivatives, were highly elevated. The biological properties and clinical significance of these metabolites merit further study.

Original languageEnglish (US)
Pages (from-to)158-160
Number of pages3
JournalJournal of Clinical Psychopharmacology
Volume4
Issue number3
StatePublished - 1984
Externally publishedYes

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Amitriptyline
Tricyclic Antidepressive Agents
Pharmacology
hydroxide ion

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Psychiatry and Mental health
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Kuhn, W. F., Jones, D. R., Lippmann, S. B., Embry, C. K., Williams, W. M., Manshadi, M. S., & Hurst, H. E. (1984). Clinical and pharmacological considerations in elimination of tricyclic antidepressants and metabolites after overdose. Journal of Clinical Psychopharmacology, 4(3), 158-160.

Clinical and pharmacological considerations in elimination of tricyclic antidepressants and metabolites after overdose. / Kuhn, Wolfgang F.; Jones, David R.; Lippmann, Steven B.; Embry, Charles K.; Williams, Walter M.; Manshadi, Manoochehr S.; Hurst, Harrell E.

In: Journal of Clinical Psychopharmacology, Vol. 4, No. 3, 1984, p. 158-160.

Research output: Contribution to journalArticle

Kuhn, WF, Jones, DR, Lippmann, SB, Embry, CK, Williams, WM, Manshadi, MS & Hurst, HE 1984, 'Clinical and pharmacological considerations in elimination of tricyclic antidepressants and metabolites after overdose', Journal of Clinical Psychopharmacology, vol. 4, no. 3, pp. 158-160.
Kuhn, Wolfgang F. ; Jones, David R. ; Lippmann, Steven B. ; Embry, Charles K. ; Williams, Walter M. ; Manshadi, Manoochehr S. ; Hurst, Harrell E. / Clinical and pharmacological considerations in elimination of tricyclic antidepressants and metabolites after overdose. In: Journal of Clinical Psychopharmacology. 1984 ; Vol. 4, No. 3. pp. 158-160.
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