Clinical Applications for Biomarkers of Acute and Chronic Graft-versus-Host Disease

John E. Levine, Sophie Paczesny, Stefanie Sarantopoulos

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

Acute and chronic graft-versus-host disease (aGVHD, cGVHD) are serious complications of allogeneic hematopoietic cell transplantation. The complex pathophysiology of these disease processes is associated with immune system activation, the release of cytokines and chemokines, and alterations in cell populations. The blood levels of specific protein and cellular levels in patients with GVHD have correlated with the development, diagnosis, and prognosis of GVHD. Here, we review the most promising biomarkers for aGVHD and cGVHD with clinical relevance. The utility of GVHD biomarkers in clinical care of allogeneic hematopoietic cell transplantation recipients needs to be proven through clinical trials, and potential approaches to trial design are discussed.

Original languageEnglish (US)
Pages (from-to)S116-S124
JournalBiology of Blood and Marrow Transplantation
Volume18
Issue number1 SUPPL.
DOIs
StatePublished - Jan 1 2012
Externally publishedYes

Keywords

  • Acute GVHD
  • Allogeneic hematopoietic cell transplantation
  • Biomarkers
  • Chronic GVHD

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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