Clinical characteristics and 12-month outcomes of patients with valvular and non-valvular atrial fibrillation in Kenya

Tecla M. Temu, Kathleen A. Lane, Changyu Shen, Loise Ng’ang’a, Constantine O. Akwanalo, Peng-Sheng Chen, Wilfred Emonyi, Susan R. Heckbert, Myra M. Koech, Imran Manji, Matteo Vatta, Eric J. Velazquez, Jennifer Wessel, Sylvester Kimaiyo, Thomas Inui, Gerald S. Bloomfield

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Atrial fibrillation (AF) is a major contributor to the global cardiovascular disease burden. The clinical profile and outcomes of AF patients with valvular heart diseases in sub-Saharan Africa (SSA) have not been adequately described. We assessed clinical features and 12-month outcomes of patients with valvular AF (vAF) in comparison to AF patients without valvular heart disease (nvAF) in western Kenya. Methods: We performed a cohort study with retrospective data gathering to characterize risk factors and prospective data collection to characterize their hospitalization, stroke and mortality rates. Results: The AF patients included 77 with vAF and 69 with nvAF. The mean (SD) age of vAF and nvAF patients were 37.9(14.5) and 69.4(12.3) years, respectively. There were significant differences (p<0.001) between vAF and nvAF patients with respect to female sex (78% vs. 55%), rates of hypertension (29% vs. 73%) and heart failure (10% vs. 49%). vAF patients were more likely to be taking anticoagulation therapy compared to those with nvAF (97% vs. 76%; p<0.01). After 12-months of follow-up, the overall mortality, hospitalization and stroke rates for vAF patients were high, at 10%, 34% and 5% respectively, and were similar to the rates in the nvAF patients (15%, 36%, and 5%, respectively). Conclusion: Despite younger age and few comorbid conditions, patients with vAF in this developing country setting are at high risk for nonfatal and fatal outcomes, and are in need of interventions to improve short and long-term outcomes.

Original languageEnglish (US)
Article numbere0185204
JournalPLoS One
Volume12
Issue number9
DOIs
StatePublished - Sep 1 2017

Fingerprint

Kenya
Atrial Fibrillation
Developing countries
Heart Valve Diseases
heart diseases
stroke
Hospitalization
Stroke
atrial fibrillation
burden of disease
Fatal Outcome
Mortality
Africa South of the Sahara
heart failure
Sub-Saharan Africa
cohort studies
hypertension
Developing Countries
cardiovascular diseases
developing countries

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Temu, T. M., Lane, K. A., Shen, C., Ng’ang’a, L., Akwanalo, C. O., Chen, P-S., ... Bloomfield, G. S. (2017). Clinical characteristics and 12-month outcomes of patients with valvular and non-valvular atrial fibrillation in Kenya. PLoS One, 12(9), [e0185204]. https://doi.org/10.1371/journal.pone.0185204

Clinical characteristics and 12-month outcomes of patients with valvular and non-valvular atrial fibrillation in Kenya. / Temu, Tecla M.; Lane, Kathleen A.; Shen, Changyu; Ng’ang’a, Loise; Akwanalo, Constantine O.; Chen, Peng-Sheng; Emonyi, Wilfred; Heckbert, Susan R.; Koech, Myra M.; Manji, Imran; Vatta, Matteo; Velazquez, Eric J.; Wessel, Jennifer; Kimaiyo, Sylvester; Inui, Thomas; Bloomfield, Gerald S.

In: PLoS One, Vol. 12, No. 9, e0185204, 01.09.2017.

Research output: Contribution to journalArticle

Temu, TM, Lane, KA, Shen, C, Ng’ang’a, L, Akwanalo, CO, Chen, P-S, Emonyi, W, Heckbert, SR, Koech, MM, Manji, I, Vatta, M, Velazquez, EJ, Wessel, J, Kimaiyo, S, Inui, T & Bloomfield, GS 2017, 'Clinical characteristics and 12-month outcomes of patients with valvular and non-valvular atrial fibrillation in Kenya', PLoS One, vol. 12, no. 9, e0185204. https://doi.org/10.1371/journal.pone.0185204
Temu, Tecla M. ; Lane, Kathleen A. ; Shen, Changyu ; Ng’ang’a, Loise ; Akwanalo, Constantine O. ; Chen, Peng-Sheng ; Emonyi, Wilfred ; Heckbert, Susan R. ; Koech, Myra M. ; Manji, Imran ; Vatta, Matteo ; Velazquez, Eric J. ; Wessel, Jennifer ; Kimaiyo, Sylvester ; Inui, Thomas ; Bloomfield, Gerald S. / Clinical characteristics and 12-month outcomes of patients with valvular and non-valvular atrial fibrillation in Kenya. In: PLoS One. 2017 ; Vol. 12, No. 9.
@article{4b4c90ff106943d7850f71c53ba28796,
title = "Clinical characteristics and 12-month outcomes of patients with valvular and non-valvular atrial fibrillation in Kenya",
abstract = "Background: Atrial fibrillation (AF) is a major contributor to the global cardiovascular disease burden. The clinical profile and outcomes of AF patients with valvular heart diseases in sub-Saharan Africa (SSA) have not been adequately described. We assessed clinical features and 12-month outcomes of patients with valvular AF (vAF) in comparison to AF patients without valvular heart disease (nvAF) in western Kenya. Methods: We performed a cohort study with retrospective data gathering to characterize risk factors and prospective data collection to characterize their hospitalization, stroke and mortality rates. Results: The AF patients included 77 with vAF and 69 with nvAF. The mean (SD) age of vAF and nvAF patients were 37.9(14.5) and 69.4(12.3) years, respectively. There were significant differences (p<0.001) between vAF and nvAF patients with respect to female sex (78{\%} vs. 55{\%}), rates of hypertension (29{\%} vs. 73{\%}) and heart failure (10{\%} vs. 49{\%}). vAF patients were more likely to be taking anticoagulation therapy compared to those with nvAF (97{\%} vs. 76{\%}; p<0.01). After 12-months of follow-up, the overall mortality, hospitalization and stroke rates for vAF patients were high, at 10{\%}, 34{\%} and 5{\%} respectively, and were similar to the rates in the nvAF patients (15{\%}, 36{\%}, and 5{\%}, respectively). Conclusion: Despite younger age and few comorbid conditions, patients with vAF in this developing country setting are at high risk for nonfatal and fatal outcomes, and are in need of interventions to improve short and long-term outcomes.",
author = "Temu, {Tecla M.} and Lane, {Kathleen A.} and Changyu Shen and Loise Ng’ang’a and Akwanalo, {Constantine O.} and Peng-Sheng Chen and Wilfred Emonyi and Heckbert, {Susan R.} and Koech, {Myra M.} and Imran Manji and Matteo Vatta and Velazquez, {Eric J.} and Jennifer Wessel and Sylvester Kimaiyo and Thomas Inui and Bloomfield, {Gerald S.}",
year = "2017",
month = "9",
day = "1",
doi = "10.1371/journal.pone.0185204",
language = "English (US)",
volume = "12",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "9",

}

TY - JOUR

T1 - Clinical characteristics and 12-month outcomes of patients with valvular and non-valvular atrial fibrillation in Kenya

AU - Temu, Tecla M.

AU - Lane, Kathleen A.

AU - Shen, Changyu

AU - Ng’ang’a, Loise

AU - Akwanalo, Constantine O.

AU - Chen, Peng-Sheng

AU - Emonyi, Wilfred

AU - Heckbert, Susan R.

AU - Koech, Myra M.

AU - Manji, Imran

AU - Vatta, Matteo

AU - Velazquez, Eric J.

AU - Wessel, Jennifer

AU - Kimaiyo, Sylvester

AU - Inui, Thomas

AU - Bloomfield, Gerald S.

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Background: Atrial fibrillation (AF) is a major contributor to the global cardiovascular disease burden. The clinical profile and outcomes of AF patients with valvular heart diseases in sub-Saharan Africa (SSA) have not been adequately described. We assessed clinical features and 12-month outcomes of patients with valvular AF (vAF) in comparison to AF patients without valvular heart disease (nvAF) in western Kenya. Methods: We performed a cohort study with retrospective data gathering to characterize risk factors and prospective data collection to characterize their hospitalization, stroke and mortality rates. Results: The AF patients included 77 with vAF and 69 with nvAF. The mean (SD) age of vAF and nvAF patients were 37.9(14.5) and 69.4(12.3) years, respectively. There were significant differences (p<0.001) between vAF and nvAF patients with respect to female sex (78% vs. 55%), rates of hypertension (29% vs. 73%) and heart failure (10% vs. 49%). vAF patients were more likely to be taking anticoagulation therapy compared to those with nvAF (97% vs. 76%; p<0.01). After 12-months of follow-up, the overall mortality, hospitalization and stroke rates for vAF patients were high, at 10%, 34% and 5% respectively, and were similar to the rates in the nvAF patients (15%, 36%, and 5%, respectively). Conclusion: Despite younger age and few comorbid conditions, patients with vAF in this developing country setting are at high risk for nonfatal and fatal outcomes, and are in need of interventions to improve short and long-term outcomes.

AB - Background: Atrial fibrillation (AF) is a major contributor to the global cardiovascular disease burden. The clinical profile and outcomes of AF patients with valvular heart diseases in sub-Saharan Africa (SSA) have not been adequately described. We assessed clinical features and 12-month outcomes of patients with valvular AF (vAF) in comparison to AF patients without valvular heart disease (nvAF) in western Kenya. Methods: We performed a cohort study with retrospective data gathering to characterize risk factors and prospective data collection to characterize their hospitalization, stroke and mortality rates. Results: The AF patients included 77 with vAF and 69 with nvAF. The mean (SD) age of vAF and nvAF patients were 37.9(14.5) and 69.4(12.3) years, respectively. There were significant differences (p<0.001) between vAF and nvAF patients with respect to female sex (78% vs. 55%), rates of hypertension (29% vs. 73%) and heart failure (10% vs. 49%). vAF patients were more likely to be taking anticoagulation therapy compared to those with nvAF (97% vs. 76%; p<0.01). After 12-months of follow-up, the overall mortality, hospitalization and stroke rates for vAF patients were high, at 10%, 34% and 5% respectively, and were similar to the rates in the nvAF patients (15%, 36%, and 5%, respectively). Conclusion: Despite younger age and few comorbid conditions, patients with vAF in this developing country setting are at high risk for nonfatal and fatal outcomes, and are in need of interventions to improve short and long-term outcomes.

UR - http://www.scopus.com/inward/record.url?scp=85029861058&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85029861058&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0185204

DO - 10.1371/journal.pone.0185204

M3 - Article

C2 - 28934312

AN - SCOPUS:85029861058

VL - 12

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 9

M1 - e0185204

ER -