Clinical Characteristics and Predictive Factors in 98 Patients with Complex Partial Seizures Treated with Temporal Resection

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Abstract

To analyze the preoperative and operative factors predictive of outcome in patients undergoing surgery for temporal lobe epilepsy. From 1984 to 1992,98 patients with medically refractory temporal lobe epilepsy underwent surgery. Evaluation included the following: Video electroencephalography (13 patients had intracranial recordings), head magnetic resonance imaging, interictal and ictal single photon emission computed tomography, psychometric testing, and Wada testing. Seizure-free groups and non-seizure-free groups were analyzed. Follow-up of 1 year to 8 years was available for 89 patients (mean, 3.2 years). Indiana University Epilepsy Surgery Program, Indianapolis. Sixty percent (53/89) were seizure free, 16% (14/89) had rare seizures, 13% (12/89) had worthwhile improvement, and 11% (10/89) showed no improvement. Fortytwo percent of seizure-free patients had a history of febrile seizures compared with 5% of non-seizure-free patients. Ictal single photon emission computed tomography showed increased flow on the side of seizure onset in 86% of seizurefree patients compared with 62% of non-seizure-free patients. Ninety-seven percent of seizure-free patients had a pathologic diagnosis; mesial temporal structures were identified in 61%. Only 64% of non-seizure-free patients had a pathologic diagnosis, and mesial temporal structures were identified in only 36% of non-seizure-free patients. Eighty-nine percent (79/89) of our patients benefited from surgery. The following factors were predictive of good outcome: a history of febrile seizures; ictal single photon emission computed tomography showing increased blood flow ipsilateral to the epileptogenic zone; a pathologic diagnosis; and the presence of mesial temporal structures in the resected tissue.

Original languageEnglish
Pages (from-to)1008-1013
Number of pages6
JournalArchives of Neurology
Volume51
Issue number10
DOIs
StatePublished - 1994

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Seizures
Single-Photon Emission-Computed Tomography
Febrile Seizures
Temporal Lobe Epilepsy
Stroke
Psychometrics
Electroencephalography
Epilepsy
Head
Magnetic Resonance Imaging
Surgery

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

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title = "Clinical Characteristics and Predictive Factors in 98 Patients with Complex Partial Seizures Treated with Temporal Resection",
abstract = "To analyze the preoperative and operative factors predictive of outcome in patients undergoing surgery for temporal lobe epilepsy. From 1984 to 1992,98 patients with medically refractory temporal lobe epilepsy underwent surgery. Evaluation included the following: Video electroencephalography (13 patients had intracranial recordings), head magnetic resonance imaging, interictal and ictal single photon emission computed tomography, psychometric testing, and Wada testing. Seizure-free groups and non-seizure-free groups were analyzed. Follow-up of 1 year to 8 years was available for 89 patients (mean, 3.2 years). Indiana University Epilepsy Surgery Program, Indianapolis. Sixty percent (53/89) were seizure free, 16{\%} (14/89) had rare seizures, 13{\%} (12/89) had worthwhile improvement, and 11{\%} (10/89) showed no improvement. Fortytwo percent of seizure-free patients had a history of febrile seizures compared with 5{\%} of non-seizure-free patients. Ictal single photon emission computed tomography showed increased flow on the side of seizure onset in 86{\%} of seizurefree patients compared with 62{\%} of non-seizure-free patients. Ninety-seven percent of seizure-free patients had a pathologic diagnosis; mesial temporal structures were identified in 61{\%}. Only 64{\%} of non-seizure-free patients had a pathologic diagnosis, and mesial temporal structures were identified in only 36{\%} of non-seizure-free patients. Eighty-nine percent (79/89) of our patients benefited from surgery. The following factors were predictive of good outcome: a history of febrile seizures; ictal single photon emission computed tomography showing increased blood flow ipsilateral to the epileptogenic zone; a pathologic diagnosis; and the presence of mesial temporal structures in the resected tissue.",
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AU - Salanova, Vicenta

AU - Markand, Omkar

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N2 - To analyze the preoperative and operative factors predictive of outcome in patients undergoing surgery for temporal lobe epilepsy. From 1984 to 1992,98 patients with medically refractory temporal lobe epilepsy underwent surgery. Evaluation included the following: Video electroencephalography (13 patients had intracranial recordings), head magnetic resonance imaging, interictal and ictal single photon emission computed tomography, psychometric testing, and Wada testing. Seizure-free groups and non-seizure-free groups were analyzed. Follow-up of 1 year to 8 years was available for 89 patients (mean, 3.2 years). Indiana University Epilepsy Surgery Program, Indianapolis. Sixty percent (53/89) were seizure free, 16% (14/89) had rare seizures, 13% (12/89) had worthwhile improvement, and 11% (10/89) showed no improvement. Fortytwo percent of seizure-free patients had a history of febrile seizures compared with 5% of non-seizure-free patients. Ictal single photon emission computed tomography showed increased flow on the side of seizure onset in 86% of seizurefree patients compared with 62% of non-seizure-free patients. Ninety-seven percent of seizure-free patients had a pathologic diagnosis; mesial temporal structures were identified in 61%. Only 64% of non-seizure-free patients had a pathologic diagnosis, and mesial temporal structures were identified in only 36% of non-seizure-free patients. Eighty-nine percent (79/89) of our patients benefited from surgery. The following factors were predictive of good outcome: a history of febrile seizures; ictal single photon emission computed tomography showing increased blood flow ipsilateral to the epileptogenic zone; a pathologic diagnosis; and the presence of mesial temporal structures in the resected tissue.

AB - To analyze the preoperative and operative factors predictive of outcome in patients undergoing surgery for temporal lobe epilepsy. From 1984 to 1992,98 patients with medically refractory temporal lobe epilepsy underwent surgery. Evaluation included the following: Video electroencephalography (13 patients had intracranial recordings), head magnetic resonance imaging, interictal and ictal single photon emission computed tomography, psychometric testing, and Wada testing. Seizure-free groups and non-seizure-free groups were analyzed. Follow-up of 1 year to 8 years was available for 89 patients (mean, 3.2 years). Indiana University Epilepsy Surgery Program, Indianapolis. Sixty percent (53/89) were seizure free, 16% (14/89) had rare seizures, 13% (12/89) had worthwhile improvement, and 11% (10/89) showed no improvement. Fortytwo percent of seizure-free patients had a history of febrile seizures compared with 5% of non-seizure-free patients. Ictal single photon emission computed tomography showed increased flow on the side of seizure onset in 86% of seizurefree patients compared with 62% of non-seizure-free patients. Ninety-seven percent of seizure-free patients had a pathologic diagnosis; mesial temporal structures were identified in 61%. Only 64% of non-seizure-free patients had a pathologic diagnosis, and mesial temporal structures were identified in only 36% of non-seizure-free patients. Eighty-nine percent (79/89) of our patients benefited from surgery. The following factors were predictive of good outcome: a history of febrile seizures; ictal single photon emission computed tomography showing increased blood flow ipsilateral to the epileptogenic zone; a pathologic diagnosis; and the presence of mesial temporal structures in the resected tissue.

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