Clinical correlates of depressive symptoms in familial Parkinson's disease

Nathan Pankratz, Karen S. Marder, Cheryl A. Halter, Alice Rudolph, Cliff W. Shults, William C. Nichols, Tatiana Foroud

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Depression is one of the most common nonmotor complications of Parkinson's disease (PD) and has a major impact on quality of life. Although several clinical factors have been associated with depression in PD, the relationship between depression and stage of illness as well as between depression and degree of disability remains controversial. We have collected clinical data on 1,378 PD cases from 632 families, using the Unified Parkinson's Disease Rating Scale (UPDRS) Parts II (activities of daily living) & III (motor), the Mini-Mental State Exam, the Geriatric Depression Scale (GDS), and the Blessed Functional Activity Scale (Blessed). Analyses were performed using the 840 individuals with verified PD and without evidence of cognitive decline. Logistic regression was used to identify study variables that individually and collectively best predicted the presence of depressive symptoms (GDS ≥ 10). After correcting for multiple tests, depressive symptoms were significantly associated with Hoehn and Yahr stage and other clinical measures but not with any genetic variant (parkin, LRRK2, APOE). The Blessed score, education, presence of a first degree relative with signs of depression, and UPDRS Part II were found to best predict depressive symptomatology (R2 = 0.33; P = 4 × 10-48). Contrary to several reports, the results from this large study indicate that stage of illness, motor impairment, and functional disability are strongly correlated with depressive symptoms.

Original languageEnglish
Pages (from-to)2216-2223
Number of pages8
JournalMovement Disorders
Volume23
Issue number15
DOIs
StatePublished - Nov 15 2008

Fingerprint

Parkinson Disease
Depression
Geriatrics
Activities of Daily Living
Logistic Models
Quality of Life
Education

Keywords

  • Activities of daily living
  • Association
  • Depression
  • Hoehn and Yahr stage
  • Parkinson's disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Pankratz, N., Marder, K. S., Halter, C. A., Rudolph, A., Shults, C. W., Nichols, W. C., & Foroud, T. (2008). Clinical correlates of depressive symptoms in familial Parkinson's disease. Movement Disorders, 23(15), 2216-2223. https://doi.org/10.1002/mds.22285

Clinical correlates of depressive symptoms in familial Parkinson's disease. / Pankratz, Nathan; Marder, Karen S.; Halter, Cheryl A.; Rudolph, Alice; Shults, Cliff W.; Nichols, William C.; Foroud, Tatiana.

In: Movement Disorders, Vol. 23, No. 15, 15.11.2008, p. 2216-2223.

Research output: Contribution to journalArticle

Pankratz, N, Marder, KS, Halter, CA, Rudolph, A, Shults, CW, Nichols, WC & Foroud, T 2008, 'Clinical correlates of depressive symptoms in familial Parkinson's disease', Movement Disorders, vol. 23, no. 15, pp. 2216-2223. https://doi.org/10.1002/mds.22285
Pankratz N, Marder KS, Halter CA, Rudolph A, Shults CW, Nichols WC et al. Clinical correlates of depressive symptoms in familial Parkinson's disease. Movement Disorders. 2008 Nov 15;23(15):2216-2223. https://doi.org/10.1002/mds.22285
Pankratz, Nathan ; Marder, Karen S. ; Halter, Cheryl A. ; Rudolph, Alice ; Shults, Cliff W. ; Nichols, William C. ; Foroud, Tatiana. / Clinical correlates of depressive symptoms in familial Parkinson's disease. In: Movement Disorders. 2008 ; Vol. 23, No. 15. pp. 2216-2223.
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