Clinical correlations of recent developments in the pathogenesis of atopic dermatitis

Sarita Sehra, Florencia M. Barbé Tuana, Mark Holbreich, Nico Mousdicas, Mark Kaplan, Jeffrey Travers

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Atopic dermatitis is a chronic inflammatory skin disease with a steadily increasing prevalence affecting 10-20 % of infants and 1-3% of adults globally. It is often the first clinical manifestation of atopic disease preceding asthma and allergic rhinitis. Probably half of the children with atopic dermatitis develop some other form of atopic disease later in life. The pathogenesis involves a complex interplay of factors including genetic predisposition due to altered immune or skin barrier function, interactions with the environment such as food and allergen exposures, and infectious triggers of inflammation. In this review, we summarize the recent advances in understanding the contribution of different factors in the pathophysiology of atopic dermatitis and how insights provide new therapeutic potential for its treatment.

Original languageEnglish
Pages (from-to)57-73
Number of pages17
JournalAnais Brasileiros de Dermatologia
Volume83
Issue number1
DOIs
StatePublished - Jan 2008

Fingerprint

Atopic Dermatitis
Genetic Predisposition to Disease
Skin Diseases
Allergens
Asthma
Inflammation
Food
Skin
Therapeutics

Keywords

  • Asthma
  • Atopic dermatitis, eczema
  • Eosinophils
  • Genetics
  • Immunoglobulin E
  • Keratinocytes
  • Rhinitis, T-lymphocytes

ASJC Scopus subject areas

  • Dermatology

Cite this

Clinical correlations of recent developments in the pathogenesis of atopic dermatitis. / Sehra, Sarita; Barbé Tuana, Florencia M.; Holbreich, Mark; Mousdicas, Nico; Kaplan, Mark; Travers, Jeffrey.

In: Anais Brasileiros de Dermatologia, Vol. 83, No. 1, 01.2008, p. 57-73.

Research output: Contribution to journalArticle

Sehra, Sarita ; Barbé Tuana, Florencia M. ; Holbreich, Mark ; Mousdicas, Nico ; Kaplan, Mark ; Travers, Jeffrey. / Clinical correlations of recent developments in the pathogenesis of atopic dermatitis. In: Anais Brasileiros de Dermatologia. 2008 ; Vol. 83, No. 1. pp. 57-73.
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