Clinical neurocardiology defining the value of neuroscience-based cardiovascular therapeutics

Kalyanam Shivkumar, Olujimi A. Ajijola, Inder Anand, J. Andrew Armour, Peng-Sheng Chen, Murray Esler, Gaetano M. De Ferrari, Michael C. Fishbein, Jeffrey J. Goldberger, Ronald M. Harper, Michael J. Joyner, Sahib S. Khalsa, Rajesh Kumar, Richard Lane, Aman Mahajan, Sunny Po, Peter J. Schwartz, Virend K. Somers, Miguel Valderrabano, Marmar VaseghiDouglas P. Zipes

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Abstract: The autonomic nervous system regulates all aspects of normal cardiac function, and is recognized to play a critical role in the pathophysiology of many cardiovascular diseases. As such, the value of neuroscience-based cardiovascular therapeutics is increasingly evident. This White Paper reviews the current state of understanding of human cardiac neuroanatomy, neurophysiology, pathophysiology in specific disease conditions, autonomic testing, risk stratification, and neuromodulatory strategies to mitigate the progression of cardiovascular diseases.

Original languageEnglish (US)
Pages (from-to)3911-3954
Number of pages44
JournalJournal of Physiology
Volume594
Issue number14
DOIs
StatePublished - Jul 15 2016

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Neurosciences
Cardiovascular Diseases
Autonomic Nervous System Diseases
Neuroanatomy
Neurophysiology
Autonomic Nervous System
Therapeutics

ASJC Scopus subject areas

  • Physiology

Cite this

Shivkumar, K., Ajijola, O. A., Anand, I., Armour, J. A., Chen, P-S., Esler, M., ... Zipes, D. P. (2016). Clinical neurocardiology defining the value of neuroscience-based cardiovascular therapeutics. Journal of Physiology, 594(14), 3911-3954. https://doi.org/10.1113/JP271870

Clinical neurocardiology defining the value of neuroscience-based cardiovascular therapeutics. / Shivkumar, Kalyanam; Ajijola, Olujimi A.; Anand, Inder; Armour, J. Andrew; Chen, Peng-Sheng; Esler, Murray; De Ferrari, Gaetano M.; Fishbein, Michael C.; Goldberger, Jeffrey J.; Harper, Ronald M.; Joyner, Michael J.; Khalsa, Sahib S.; Kumar, Rajesh; Lane, Richard; Mahajan, Aman; Po, Sunny; Schwartz, Peter J.; Somers, Virend K.; Valderrabano, Miguel; Vaseghi, Marmar; Zipes, Douglas P.

In: Journal of Physiology, Vol. 594, No. 14, 15.07.2016, p. 3911-3954.

Research output: Contribution to journalArticle

Shivkumar, K, Ajijola, OA, Anand, I, Armour, JA, Chen, P-S, Esler, M, De Ferrari, GM, Fishbein, MC, Goldberger, JJ, Harper, RM, Joyner, MJ, Khalsa, SS, Kumar, R, Lane, R, Mahajan, A, Po, S, Schwartz, PJ, Somers, VK, Valderrabano, M, Vaseghi, M & Zipes, DP 2016, 'Clinical neurocardiology defining the value of neuroscience-based cardiovascular therapeutics', Journal of Physiology, vol. 594, no. 14, pp. 3911-3954. https://doi.org/10.1113/JP271870
Shivkumar, Kalyanam ; Ajijola, Olujimi A. ; Anand, Inder ; Armour, J. Andrew ; Chen, Peng-Sheng ; Esler, Murray ; De Ferrari, Gaetano M. ; Fishbein, Michael C. ; Goldberger, Jeffrey J. ; Harper, Ronald M. ; Joyner, Michael J. ; Khalsa, Sahib S. ; Kumar, Rajesh ; Lane, Richard ; Mahajan, Aman ; Po, Sunny ; Schwartz, Peter J. ; Somers, Virend K. ; Valderrabano, Miguel ; Vaseghi, Marmar ; Zipes, Douglas P. / Clinical neurocardiology defining the value of neuroscience-based cardiovascular therapeutics. In: Journal of Physiology. 2016 ; Vol. 594, No. 14. pp. 3911-3954.
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