Clinical Perspectives in the Diagnosis and Management of Histoplasmosis

Marwan M. Azar, Chadi Hage

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

With increasing numbers of travelers and immunocompromised patients, histoplasmosis, caused by the dimorphic fungus Histoplasma capsulatum, has become a disease of national extent. The clinical spectrum of histoplasmosis is very wide, in terms of disease cadence, onset, distribution, and severity. A multipronged approach is recommended for diagnosis. Manifestations that are always treated include moderate to severe acute pulmonary histoplasmosis, disseminated disease, and histoplasmosis in immunocompromised individuals. Amphotericin B is the drug of choice for moderate to severe and disseminated presentations, whereas itraconazole is appropriate for mild disease and as step-down therapy.

Original languageEnglish (US)
Pages (from-to)403-415
Number of pages13
JournalClinics in Chest Medicine
Volume38
Issue number3
DOIs
StatePublished - Sep 1 2017

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Histoplasmosis
Histoplasma
Itraconazole
Immunocompromised Host
Amphotericin B
Fungi
Lung
Pharmaceutical Preparations
Therapeutics

Keywords

  • Diagnosis
  • Endemic
  • Histoplasmosis
  • Treatment

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Clinical Perspectives in the Diagnosis and Management of Histoplasmosis. / Azar, Marwan M.; Hage, Chadi.

In: Clinics in Chest Medicine, Vol. 38, No. 3, 01.09.2017, p. 403-415.

Research output: Contribution to journalReview article

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