Clinical Perspectives in the Diagnosis and Management of Histoplasmosis

Marwan M. Azar, Chadi Hage

Research output: Contribution to journalReview article

16 Scopus citations


With increasing numbers of travelers and immunocompromised patients, histoplasmosis, caused by the dimorphic fungus Histoplasma capsulatum, has become a disease of national extent. The clinical spectrum of histoplasmosis is very wide, in terms of disease cadence, onset, distribution, and severity. A multipronged approach is recommended for diagnosis. Manifestations that are always treated include moderate to severe acute pulmonary histoplasmosis, disseminated disease, and histoplasmosis in immunocompromised individuals. Amphotericin B is the drug of choice for moderate to severe and disseminated presentations, whereas itraconazole is appropriate for mild disease and as step-down therapy.

Original languageEnglish (US)
Pages (from-to)403-415
Number of pages13
JournalClinics in Chest Medicine
Issue number3
StatePublished - Sep 1 2017


  • Diagnosis
  • Endemic
  • Histoplasmosis
  • Treatment

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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