Clinical pharmacology of bimatoprost

Research output: Contribution to journalArticle

15 Scopus citations


Bimatoprost (Lumigan®, Allergan) is a highly efficacious ocular hypotensive agent that provides good diurnal control of intraocular pressure in glaucoma and ocular hypertensive patients. Bimatoprost is a synthetic molecule that is structurally and pharmacologically similar to prostamide F , and appears to mimic the activity of the prostamides. Consistent with prostamide-mimetic activity, bimatoprost has potent inherent pharmacological activity in prostamide-sensitive preparations and essentially remains intact in the living primate eye. This is sufficient to explain its potent and efficacious ocular hypotensive activity, and suggests that bimatoprost is a pharmacologically unique compound.

Original languageEnglish (US)
Pages (from-to)151-157
Number of pages7
JournalExpert Opinion on Drug Metabolism and Toxicology
Issue number1
StatePublished - Jun 1 2005


  • bimatoprost
  • glaucoma
  • intraocular pressure
  • metabolism
  • prostaglandin
  • prostamide

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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