Clinical presentation of hispanic (H) patients (PTS) with multiple myeloma (MM) in bexar county (BC), Texas

N. S. Callander, J. Galvez, R. Cortes, M. Aisina, G. David Roodman

Research output: Contribution to journalArticle

Abstract

Multiple myeloma is an incurable B cell malignancy with an incidence in the US of 4/ 10,000. Epidemiologie studies consistently show a 2-3 fold increased risk among AfroAmericans (AA). The reason for this excess remains obscure but may be related to genetic susceptibility. However, little is known about the disease characteristics of MM in H pts. BC, comprising San Antonio TX, contains one of the largest H populations in the US. Census figures for 1997 show the ethnic breakdown of BC to be: 51.8% H, 39.5% Caucasian (C) and 6.8% AA. This H population is a genetic admixture with native American, European and about 8% African sources. We wondered if the epidemiology of MM in H pts would more closely resemble that of AA or C populations. One-hundred forty six MM pts are followed through a general clinical research center in SA. The ethnicity of pts is as follows: 39%H, 40%C, 10% AA. We determined the age, sex, stage and M protein of these pts. Total H C AA Age 61 58 64 59 Male 63% 59% 73% 62% Stage III 79% 85% 78% 77% Stage B 9% 12% 2% 15% light chain only 22% 14% 22% 23% IgG 52% 55% 51% 62% Conclusions: The presentation of H pts with MM in BC resembles that of C rather than A pts in the US, although a significantly higher percentage of H pts than C pts (p

Original languageEnglish (US)
JournalBlood
Volume96
Issue number11 PART II
StatePublished - 2000
Externally publishedYes

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Epidemiology
Multiple Myeloma
Hispanic Americans
Immunoglobulin G
Cells
Proteins
Population
North American Indians
Censuses
Genetic Predisposition to Disease
B-Lymphocytes
Light
Incidence
Research
Neoplasms

ASJC Scopus subject areas

  • Hematology

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Clinical presentation of hispanic (H) patients (PTS) with multiple myeloma (MM) in bexar county (BC), Texas. / Callander, N. S.; Galvez, J.; Cortes, R.; Aisina, M.; Roodman, G. David.

In: Blood, Vol. 96, No. 11 PART II, 2000.

Research output: Contribution to journalArticle

Callander, N. S. ; Galvez, J. ; Cortes, R. ; Aisina, M. ; Roodman, G. David. / Clinical presentation of hispanic (H) patients (PTS) with multiple myeloma (MM) in bexar county (BC), Texas. In: Blood. 2000 ; Vol. 96, No. 11 PART II.
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abstract = "Multiple myeloma is an incurable B cell malignancy with an incidence in the US of 4/ 10,000. Epidemiologie studies consistently show a 2-3 fold increased risk among AfroAmericans (AA). The reason for this excess remains obscure but may be related to genetic susceptibility. However, little is known about the disease characteristics of MM in H pts. BC, comprising San Antonio TX, contains one of the largest H populations in the US. Census figures for 1997 show the ethnic breakdown of BC to be: 51.8{\%} H, 39.5{\%} Caucasian (C) and 6.8{\%} AA. This H population is a genetic admixture with native American, European and about 8{\%} African sources. We wondered if the epidemiology of MM in H pts would more closely resemble that of AA or C populations. One-hundred forty six MM pts are followed through a general clinical research center in SA. The ethnicity of pts is as follows: 39{\%}H, 40{\%}C, 10{\%} AA. We determined the age, sex, stage and M protein of these pts. Total H C AA Age 61 58 64 59 Male 63{\%} 59{\%} 73{\%} 62{\%} Stage III 79{\%} 85{\%} 78{\%} 77{\%} Stage B 9{\%} 12{\%} 2{\%} 15{\%} light chain only 22{\%} 14{\%} 22{\%} 23{\%} IgG 52{\%} 55{\%} 51{\%} 62{\%} Conclusions: The presentation of H pts with MM in BC resembles that of C rather than A pts in the US, although a significantly higher percentage of H pts than C pts (p",
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