Clinical stage I pure yolk sac tumor of the testis in adults has different clinical behavior than juvenile yolk sac tumor

Richard S. Foster, Benoit Hermans, Richard Bihrle, John P. Donohue

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Purpose: We evaluated the clinical behavior of clinical stage I pure yolk sac tumor of the testis in adults to determine whether the behavior of this entity is different than that of clinical stage 1 nonseminoma. Materials and Methods: We searched the testis cancer database at our institution for adults with clinical stage I pure yolk sac tumor of the testis who underwent retroperitoneal lymph node dissection. We identified 12 such patients and reviewed the database and hospital charts to determine clinical behavior. Results: Disease was pathological stage I in 8 of the 12 patients (66%), including 1 with recurrence after retroperitoneal lymph node dissection. Disease was pathological stage II in 14 patients (33%), including 1 who remains disease-free after electing adjuvant bleomycin, etoposide and cisplatin. Of the 3 patients who elected observation after retroperitoneal lymph node dissection only 1 has had recurrence, while 2 (66%) were cured by retroperitoneal lymph node dissection only. Conclusions: Contrary to juvenile yolk sac tumor, which has a strong tendency toward hematogenous metastasis, the behavior of clinical stage I adult pure yolk sac tumor is similar to that of all other stage I nonseminomas in adulthood.

Original languageEnglish (US)
Pages (from-to)1943-1944
Number of pages2
JournalJournal of Urology
Volume164
Issue number6
DOIs
StatePublished - Jan 1 2000

Keywords

  • Lymph node excision
  • Testis
  • Yolk sac tumor

ASJC Scopus subject areas

  • Urology

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