Clinical utility of EUS-guided fine-needle aspiration of mediastinal masses in the absence of known pulmonary malignancy

Benedict M. Devereaux, Julia Kim LeBlanc, Edward Yousif, Kenneth Kesler, Jo Ann Brooks, Praveen Mathur, Alan Sandler, John Chappo, Glen A. Lehman, Stuart Sherman, Frank Gress, Donato Ciaccia

Research output: Contribution to journalArticle

53 Scopus citations


Background: Mediastinal masses represent a diagnostic challenge because of their proximity to numerous critical structures, difficulty of access for tissue sampling, and myriad potential pathologic etiologies. A large, single-center experience with EUS-guided fine-needle aspiration (EUSFNA) in the diagnosis of non-lung cancer-related mediastinal masses is presented. Methods: An EUS database was reviewed and all cases of mediastinal mass or lymphadenopathy encountered between 1994 and 1999 were included. Final diagnoses were determined by EUS-FNA cytology and clinical follow-up. Results: Forty-nine patients were identified (27 women, 22 men; mean age 58.1 years, range 30-89 years). A malignant process was diagnosed in 22 cases (45%) and a benign process in 24 (49%). The EUS-FNA specimen was nondiagnostic in 3 cases (6%). An accurate diagnosis was made in 46 of the 49 patients (94%). No complication was noted. Conclusions: EUS-FNA is a minimally invasive technique that facilitates detection and tissue sampling of mediastinal masses. It is a safe procedure that can be performed with the patient under conscious sedation in an outpatient setting.

Original languageEnglish (US)
Pages (from-to)397-401
Number of pages5
JournalGastrointestinal endoscopy
Issue number3
StatePublished - Jan 1 2002


ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

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