Clinical utility of immunohistochemistry in the diagnoses of urinary bladder neoplasia

Kurt B. Hodges, Antonio Lopez-Beltran, Robert Emerson, Rodolfo Montironi, Liang Cheng

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Urothelial carcinomas demonstrate diverse morphologic and immunologic features that frequently lead to diagnostic challenges. Recent advances have identified a number of immunohistochemical stains that, when used in the context of a panel, can be a valuable tool in properly classifying primary urothelial carcinoma and carcinomas secondarily involving the urinary bladder. In addition, new biomarkers prove helpful in the staging of bladder carcinoma. In this article, we review the clinical utility of immunohistochemistry in a series of diagnostic scenarios, including flat urothelial lesions with atypia, rare variants of urothelial carcinoma, primary adenocarcinoma versus secondary colorectal tumors, distinguishing prostate from urothelial carcinoma, and the utility of smoothelin in staging bladder carcinoma. Emphasis is placed on panels of commonly used biomarkers to establish diagnoses.

Original languageEnglish
Pages (from-to)401-410
Number of pages10
JournalApplied Immunohistochemistry and Molecular Morphology
Volume18
Issue number5
DOIs
StatePublished - Oct 2010

Fingerprint

Urinary Bladder
Immunohistochemistry
Carcinoma
Neoplasms
Biomarkers
Prostate
Colorectal Neoplasms
Adenocarcinoma
Coloring Agents

Keywords

  • biomarkers
  • bladder
  • differential diagnosis
  • histogenesis
  • immunohistochemistry
  • transitional cell carcinoma (TCC) variants
  • urothelial carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology
  • Histology

Cite this

Clinical utility of immunohistochemistry in the diagnoses of urinary bladder neoplasia. / Hodges, Kurt B.; Lopez-Beltran, Antonio; Emerson, Robert; Montironi, Rodolfo; Cheng, Liang.

In: Applied Immunohistochemistry and Molecular Morphology, Vol. 18, No. 5, 10.2010, p. 401-410.

Research output: Contribution to journalArticle

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