Clinical/ERCP manifestations in idiopathic pancreatitis (IP): Cystic fibrosis (CF) heterozygous gene positive and negative patients

C. P. Choudari, A. C. Yu, Evan Fogel, Stuart Sherman, Glen Lehman

Research output: Contribution to journalArticle

Abstract

In patients (pts) with IP we have shown a CF heterozygous gene abnormality in 19% compared to 3.5% in patients without pancreatitis. We compared the initial clinical manifestations and ERCP findings in patients with and without the heterozygous state for CF in a cohort of pts with IP. Methods: Nineteen pts with CF heterozygous positive were compared to 85 pts who were CF heterozygous negative. All pts presented with two or more episodes of unexplained pancreatitis. Pancreatograms were evaluated for chronic pancreatitis (CP) based on Cambridge criteria. Results: CF Heterozygous CF Heterozygous +ve (n=19) -ve (n=85) Sex: M:F 11:8 29:56 Age: mean (range) 38 (17-76) 42 (14-77) Onset of symptoms mean (range) 34 (13-65) 38 (8-67) Cholecystectomy 9 (47%) 48 (56%) ERCP Findings: Normal 6 (32%) 30 (35%) Equivocal CP 1 (5%) 3 (4%) Grade I CP 3 (16%) 22 (26%) Grade II CP 1 (5%) 6 (7%) Grade III CP 8 (42%) 24 (28%) Pseudocyst 0 (0%) 5 (6%) Stricture 3 (16%) 18 (21%) Stone disease 5 (26%) 8 (9%) Summary: 1) The age of onset of symptoms in both groups were similar. 2) Nearly half the pts in both groups (47% vs 56%) had their gallbladder removed prior to ERCP assessment. 3) Grade III CP and stone disease tended to be more common in the group who were CF heterozygous positive. Conclusions: This study is ongoing and long-term follow-up will be necessary to determine whether the heterozygous state confers a poorer prognosis.

Original languageEnglish
JournalGastrointestinal Endoscopy
Volume47
Issue number4
StatePublished - 1998

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Endoscopic Retrograde Cholangiopancreatography
Cystic Fibrosis
Pancreatitis
Chronic Pancreatitis
Genes
Cholecystectomy
Gallbladder
Age of Onset
Pathologic Constriction

ASJC Scopus subject areas

  • Gastroenterology

Cite this

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title = "Clinical/ERCP manifestations in idiopathic pancreatitis (IP): Cystic fibrosis (CF) heterozygous gene positive and negative patients",
abstract = "In patients (pts) with IP we have shown a CF heterozygous gene abnormality in 19{\%} compared to 3.5{\%} in patients without pancreatitis. We compared the initial clinical manifestations and ERCP findings in patients with and without the heterozygous state for CF in a cohort of pts with IP. Methods: Nineteen pts with CF heterozygous positive were compared to 85 pts who were CF heterozygous negative. All pts presented with two or more episodes of unexplained pancreatitis. Pancreatograms were evaluated for chronic pancreatitis (CP) based on Cambridge criteria. Results: CF Heterozygous CF Heterozygous +ve (n=19) -ve (n=85) Sex: M:F 11:8 29:56 Age: mean (range) 38 (17-76) 42 (14-77) Onset of symptoms mean (range) 34 (13-65) 38 (8-67) Cholecystectomy 9 (47{\%}) 48 (56{\%}) ERCP Findings: Normal 6 (32{\%}) 30 (35{\%}) Equivocal CP 1 (5{\%}) 3 (4{\%}) Grade I CP 3 (16{\%}) 22 (26{\%}) Grade II CP 1 (5{\%}) 6 (7{\%}) Grade III CP 8 (42{\%}) 24 (28{\%}) Pseudocyst 0 (0{\%}) 5 (6{\%}) Stricture 3 (16{\%}) 18 (21{\%}) Stone disease 5 (26{\%}) 8 (9{\%}) Summary: 1) The age of onset of symptoms in both groups were similar. 2) Nearly half the pts in both groups (47{\%} vs 56{\%}) had their gallbladder removed prior to ERCP assessment. 3) Grade III CP and stone disease tended to be more common in the group who were CF heterozygous positive. Conclusions: This study is ongoing and long-term follow-up will be necessary to determine whether the heterozygous state confers a poorer prognosis.",
author = "Choudari, {C. P.} and Yu, {A. C.} and Evan Fogel and Stuart Sherman and Glen Lehman",
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T1 - Clinical/ERCP manifestations in idiopathic pancreatitis (IP)

T2 - Cystic fibrosis (CF) heterozygous gene positive and negative patients

AU - Choudari, C. P.

AU - Yu, A. C.

AU - Fogel, Evan

AU - Sherman, Stuart

AU - Lehman, Glen

PY - 1998

Y1 - 1998

N2 - In patients (pts) with IP we have shown a CF heterozygous gene abnormality in 19% compared to 3.5% in patients without pancreatitis. We compared the initial clinical manifestations and ERCP findings in patients with and without the heterozygous state for CF in a cohort of pts with IP. Methods: Nineteen pts with CF heterozygous positive were compared to 85 pts who were CF heterozygous negative. All pts presented with two or more episodes of unexplained pancreatitis. Pancreatograms were evaluated for chronic pancreatitis (CP) based on Cambridge criteria. Results: CF Heterozygous CF Heterozygous +ve (n=19) -ve (n=85) Sex: M:F 11:8 29:56 Age: mean (range) 38 (17-76) 42 (14-77) Onset of symptoms mean (range) 34 (13-65) 38 (8-67) Cholecystectomy 9 (47%) 48 (56%) ERCP Findings: Normal 6 (32%) 30 (35%) Equivocal CP 1 (5%) 3 (4%) Grade I CP 3 (16%) 22 (26%) Grade II CP 1 (5%) 6 (7%) Grade III CP 8 (42%) 24 (28%) Pseudocyst 0 (0%) 5 (6%) Stricture 3 (16%) 18 (21%) Stone disease 5 (26%) 8 (9%) Summary: 1) The age of onset of symptoms in both groups were similar. 2) Nearly half the pts in both groups (47% vs 56%) had their gallbladder removed prior to ERCP assessment. 3) Grade III CP and stone disease tended to be more common in the group who were CF heterozygous positive. Conclusions: This study is ongoing and long-term follow-up will be necessary to determine whether the heterozygous state confers a poorer prognosis.

AB - In patients (pts) with IP we have shown a CF heterozygous gene abnormality in 19% compared to 3.5% in patients without pancreatitis. We compared the initial clinical manifestations and ERCP findings in patients with and without the heterozygous state for CF in a cohort of pts with IP. Methods: Nineteen pts with CF heterozygous positive were compared to 85 pts who were CF heterozygous negative. All pts presented with two or more episodes of unexplained pancreatitis. Pancreatograms were evaluated for chronic pancreatitis (CP) based on Cambridge criteria. Results: CF Heterozygous CF Heterozygous +ve (n=19) -ve (n=85) Sex: M:F 11:8 29:56 Age: mean (range) 38 (17-76) 42 (14-77) Onset of symptoms mean (range) 34 (13-65) 38 (8-67) Cholecystectomy 9 (47%) 48 (56%) ERCP Findings: Normal 6 (32%) 30 (35%) Equivocal CP 1 (5%) 3 (4%) Grade I CP 3 (16%) 22 (26%) Grade II CP 1 (5%) 6 (7%) Grade III CP 8 (42%) 24 (28%) Pseudocyst 0 (0%) 5 (6%) Stricture 3 (16%) 18 (21%) Stone disease 5 (26%) 8 (9%) Summary: 1) The age of onset of symptoms in both groups were similar. 2) Nearly half the pts in both groups (47% vs 56%) had their gallbladder removed prior to ERCP assessment. 3) Grade III CP and stone disease tended to be more common in the group who were CF heterozygous positive. Conclusions: This study is ongoing and long-term follow-up will be necessary to determine whether the heterozygous state confers a poorer prognosis.

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