Clinical/ERCP manifestations in idiopathic pancreatitis (IP): Cystic fibrosis (CF) heterozygous gene positive and negative patients

C. P. Choudari, A. C. Yu, E. L. Fogel, S. Sherman, G. A. Lehman

Research output: Contribution to journalArticle

Abstract

In patients (pts) with IP we have shown a CF heterozygous gene abnormality in 19% compared to 3.5% in patients without pancreatitis. We compared the initial clinical manifestations and ERCP findings in patients with and without the heterozygous state for CF in a cohort of pts with IP. Methods: Nineteen pts with CF heterozygous positive were compared to 85 pts who were CF heterozygous negative. All pts presented with two or more episodes of unexplained pancreatitis. Pancreatograms were evaluated for chronic pancreatitis (CP) based on Cambridge criteria. Results: CF Heterozygous CF Heterozygous +ve (n=19) -ve (n=85) Sex: M:F 11:8 29:56 Age: mean (range) 38 (17-76) 42 (14-77) Onset of symptoms mean (range) 34 (13-65) 38 (8-67) Cholecystectomy 9 (47%) 48 (56%) ERCP Findings: Normal 6 (32%) 30 (35%) Equivocal CP 1 (5%) 3 (4%) Grade I CP 3 (16%) 22 (26%) Grade II CP 1 (5%) 6 (7%) Grade III CP 8 (42%) 24 (28%) Pseudocyst 0 (0%) 5 (6%) Stricture 3 (16%) 18 (21%) Stone disease 5 (26%) 8 (9%) Summary: 1) The age of onset of symptoms in both groups were similar. 2) Nearly half the pts in both groups (47% vs 56%) had their gallbladder removed prior to ERCP assessment. 3) Grade III CP and stone disease tended to be more common in the group who were CF heterozygous positive. Conclusions: This study is ongoing and long-term follow-up will be necessary to determine whether the heterozygous state confers a poorer prognosis.

Original languageEnglish (US)
Pages (from-to)AB134
JournalGastrointestinal endoscopy
Volume47
Issue number4
StatePublished - Dec 1 1998

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

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