Clinico-Pathological Correlation in Progressive Ataxia and Palatal Tremor: A Novel Tauopathy

Zoltan Mari, Andrew J.M. Halls, Alexander Vortmeyer, Victoria Zhukareva, Kunihiro Uryu, Virginia M.Y. Lee, Mark Hallett

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Palatal tremor (PT) is an uncommon movement disorder that has been subdivided into essential and symptomatic forms. A distinct subgroup of the symptomatic form presents with progressive ataxia and PT. The histopathology of progressive ataxia and PT has not been previously determined. This study consisted of a clinical review, histopathology, and electron microscopy of the brain of a man with progressive ataxia and PT. The inferior olivary hypertrophy was symmetrical and homogenous, and no focal pathologic lesions could be identified in the brainstem. Insoluble tau deposits were found in neurons, exclusively infratentorially. We present the clinical and pathological evaluation of a case of progressive ataxia and PT that provide evidence for a unique form of 4R tauopathy.

Original languageEnglish (US)
Pages (from-to)50-56
Number of pages7
JournalMovement Disorders Clinical Practice
Volume1
Issue number1
DOIs
StatePublished - Apr 1 2014
Externally publishedYes

Fingerprint

Tauopathies
Tremor
Ataxia
Movement Disorders
Hypertrophy
Brain Stem
Electron Microscopy
Neurons
Brain

Keywords

  • Ataxia
  • Neurodegenerative disorders
  • Neuropathology
  • Tremor

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Clinico-Pathological Correlation in Progressive Ataxia and Palatal Tremor : A Novel Tauopathy. / Mari, Zoltan; Halls, Andrew J.M.; Vortmeyer, Alexander; Zhukareva, Victoria; Uryu, Kunihiro; Lee, Virginia M.Y.; Hallett, Mark.

In: Movement Disorders Clinical Practice, Vol. 1, No. 1, 01.04.2014, p. 50-56.

Research output: Contribution to journalArticle

Mari, Zoltan ; Halls, Andrew J.M. ; Vortmeyer, Alexander ; Zhukareva, Victoria ; Uryu, Kunihiro ; Lee, Virginia M.Y. ; Hallett, Mark. / Clinico-Pathological Correlation in Progressive Ataxia and Palatal Tremor : A Novel Tauopathy. In: Movement Disorders Clinical Practice. 2014 ; Vol. 1, No. 1. pp. 50-56.
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