Clinicopathologic and interphase cytogenetic analysis of papillary (chromophilic) renal cell carcinoma

Mireille M. Kattar, David Grignon, Tracie Wallis, Gabriel P. Haas, Wael A. Sakr, J. Edson Pontes, Daniel W. Visscher

Research output: Contribution to journalArticle

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Abstract

Trisomy 7 and 17 with deletion of Y is typical of papillary renal cell adenoma (PRCA), and additional alterations occur in the putative genetic progression toward papillary renal cell carcinoma (PRCC). Our study correlated aneuploidy with clinicopathologic features in PRCCs. We used fluorescence in situ hybridization to assess copy number for chromosomes 7, 8, 10, 12, 16, 17, and Y in 16 PRCCs and surrounding benign tubular parenchyma from 15 patients by use of α satellite (centromere) probes on deparaffinized tissue sections. We then compared the pattern of monosomy/nullisomy or trisomy/polysomy/hemidisomy to clinicopathologic parameters. Nine minors (58% Group 1) showed the numeric aberrations typical of PRCAs and PRCCs, with gains of 7 and 17 and loss of Y. We also identified four trisomies of 12 and 16 and one of 8 in Group 1. The remaining seven cases (Group 2) were cytogenetically atypical. Two displayed borderline loss of chromosome 7, although trisomy 17 was present in both. Five had trisomy 7, but none exhibited chromosome 17 alterations, and two exhibited a gain of Y. Neoplasms in Group 2 were less often multicentric than were Group 1 tumors, and they contained foamy macrophage infiltrates less often. One chromophilic carcinoma with abundant clear cells and another with oncocytic features exhibited Group 2 chromosomal profiles. One patient (nuclear grade 4) died from disease, and 14 had no evidence of carcinoma at the last follow-up. We concluded that PRCCs represent a histologically and genotypically heterogeneous group of tumors. If PRGAs consistently exhibit +7, +17, and - Y, it is uncertain whether PRCCs always evolve directly from such lesions. The presence of genotypic heterogeneity might reflect histologic variants of PRCCs, which overlap with other types of RCC. PRCC is generally an indolent neoplasm, despite a high frequency of chromosomal aneuploidy.

Original languageEnglish (US)
Pages (from-to)1143-1150
Number of pages8
JournalModern Pathology
Volume10
Issue number11
StatePublished - Nov 1997
Externally publishedYes

Fingerprint

Cytogenetic Analysis
Interphase
Renal Cell Carcinoma
Chromosomes, Human, Pair 7
Trisomy
Aneuploidy
Neoplasms
Carcinoma
Minors
Monosomy
Chromosomes, Human, Pair 8
Chromosomes, Human, Pair 17
Centromere
Fluorescence In Situ Hybridization
Adenoma
Macrophages
Kidney
Chromosome 17 trisomy

Keywords

  • Chromophil
  • Fluorescence in situ hybridization
  • Papillary renal cell adenoma
  • Papillary renal cell carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Kattar, M. M., Grignon, D., Wallis, T., Haas, G. P., Sakr, W. A., Edson Pontes, J., & Visscher, D. W. (1997). Clinicopathologic and interphase cytogenetic analysis of papillary (chromophilic) renal cell carcinoma. Modern Pathology, 10(11), 1143-1150.

Clinicopathologic and interphase cytogenetic analysis of papillary (chromophilic) renal cell carcinoma. / Kattar, Mireille M.; Grignon, David; Wallis, Tracie; Haas, Gabriel P.; Sakr, Wael A.; Edson Pontes, J.; Visscher, Daniel W.

In: Modern Pathology, Vol. 10, No. 11, 11.1997, p. 1143-1150.

Research output: Contribution to journalArticle

Kattar, MM, Grignon, D, Wallis, T, Haas, GP, Sakr, WA, Edson Pontes, J & Visscher, DW 1997, 'Clinicopathologic and interphase cytogenetic analysis of papillary (chromophilic) renal cell carcinoma', Modern Pathology, vol. 10, no. 11, pp. 1143-1150.
Kattar MM, Grignon D, Wallis T, Haas GP, Sakr WA, Edson Pontes J et al. Clinicopathologic and interphase cytogenetic analysis of papillary (chromophilic) renal cell carcinoma. Modern Pathology. 1997 Nov;10(11):1143-1150.
Kattar, Mireille M. ; Grignon, David ; Wallis, Tracie ; Haas, Gabriel P. ; Sakr, Wael A. ; Edson Pontes, J. ; Visscher, Daniel W. / Clinicopathologic and interphase cytogenetic analysis of papillary (chromophilic) renal cell carcinoma. In: Modern Pathology. 1997 ; Vol. 10, No. 11. pp. 1143-1150.
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abstract = "Trisomy 7 and 17 with deletion of Y is typical of papillary renal cell adenoma (PRCA), and additional alterations occur in the putative genetic progression toward papillary renal cell carcinoma (PRCC). Our study correlated aneuploidy with clinicopathologic features in PRCCs. We used fluorescence in situ hybridization to assess copy number for chromosomes 7, 8, 10, 12, 16, 17, and Y in 16 PRCCs and surrounding benign tubular parenchyma from 15 patients by use of α satellite (centromere) probes on deparaffinized tissue sections. We then compared the pattern of monosomy/nullisomy or trisomy/polysomy/hemidisomy to clinicopathologic parameters. Nine minors (58{\%} Group 1) showed the numeric aberrations typical of PRCAs and PRCCs, with gains of 7 and 17 and loss of Y. We also identified four trisomies of 12 and 16 and one of 8 in Group 1. The remaining seven cases (Group 2) were cytogenetically atypical. Two displayed borderline loss of chromosome 7, although trisomy 17 was present in both. Five had trisomy 7, but none exhibited chromosome 17 alterations, and two exhibited a gain of Y. Neoplasms in Group 2 were less often multicentric than were Group 1 tumors, and they contained foamy macrophage infiltrates less often. One chromophilic carcinoma with abundant clear cells and another with oncocytic features exhibited Group 2 chromosomal profiles. One patient (nuclear grade 4) died from disease, and 14 had no evidence of carcinoma at the last follow-up. We concluded that PRCCs represent a histologically and genotypically heterogeneous group of tumors. If PRGAs consistently exhibit +7, +17, and - Y, it is uncertain whether PRCCs always evolve directly from such lesions. The presence of genotypic heterogeneity might reflect histologic variants of PRCCs, which overlap with other types of RCC. PRCC is generally an indolent neoplasm, despite a high frequency of chromosomal aneuploidy.",
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