Clinicopathological significance of lymphovascular invasion in urothelial carcinoma

Roberta Mazzucchelli, Liang Cheng, Antonio Lopez-Beltran, Marina Scarpelli, Rodolfo Montironi

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Lymphovascular invasion is an important prognostic marker in the assessment of bladder cancer, including both cystectomy and transurethral resection of the bladder specimens, and should routinely be reported upon in the pathological report. Strict criteria must be utilized in establishing a diagnosis of lymphovascular invasion in urothelial carcinoma to distinguish it from peritumoral stromal retraction, a common finding that often mimics a vascular space. The use of immunohistochemistry (CD31, CD34, D2-40) for the diagnosis of intravascular invasion in urothelial carcinoma should be used only in selected histologically equivocal cases for confirmation. Routine use of immunohistochemistry for endothelium as a screening test in all cases cannot be recommended.

Original languageEnglish (US)
Pages (from-to)173-179
Number of pages7
JournalAnalytical and Quantitative Cytology and Histology
Volume34
Issue number4
StatePublished - Aug 1 2012

Keywords

  • CD31 antigen
  • CD34 antigen
  • Immunochemistry
  • Lymphovascular invasion
  • Urothelial carcinoma
  • Urothelial neoplasms
  • Urothelium

ASJC Scopus subject areas

  • Anatomy
  • Histology

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  • Cite this

    Mazzucchelli, R., Cheng, L., Lopez-Beltran, A., Scarpelli, M., & Montironi, R. (2012). Clinicopathological significance of lymphovascular invasion in urothelial carcinoma. Analytical and Quantitative Cytology and Histology, 34(4), 173-179.