Clinicopathological significance of lymphovascular invasion in urothelial carcinoma

Roberta Mazzucchelli, Liang Cheng, Antonio Lopez-Beltran, Marina Scarpelli, Rodolfo Montironi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Lymphovascular invasion is an important prognostic marker in the assessment of bladder cancer, including both cystectomy and transurethral resection of the bladder specimens, and should routinely be reported upon in the pathological report. Strict criteria must be utilized in establishing a diagnosis of lymphovascular invasion in urothelial carcinoma to distinguish it from peritumoral stromal retraction, a common finding that often mimics a vascular space. The use of immunohistochemistry (CD31, CD34, D2-40) for the diagnosis of intravascular invasion in urothelial carcinoma should be used only in selected histologically equivocal cases for confirmation. Routine use of immunohistochemistry for endothelium as a screening test in all cases cannot be recommended.

Original languageEnglish
Pages (from-to)173-179
Number of pages7
JournalAnalytical and Quantitative Cytology and Histology
Volume34
Issue number4
StatePublished - Aug 2012

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Immunohistochemistry
Carcinoma
Cystectomy
Urinary Bladder Neoplasms
Endothelium
Blood Vessels
Urinary Bladder

Keywords

  • CD31 antigen
  • CD34 antigen
  • Immunochemistry
  • Lymphovascular invasion
  • Urothelial carcinoma
  • Urothelial neoplasms
  • Urothelium

ASJC Scopus subject areas

  • Anatomy
  • Histology

Cite this

Mazzucchelli, R., Cheng, L., Lopez-Beltran, A., Scarpelli, M., & Montironi, R. (2012). Clinicopathological significance of lymphovascular invasion in urothelial carcinoma. Analytical and Quantitative Cytology and Histology, 34(4), 173-179.

Clinicopathological significance of lymphovascular invasion in urothelial carcinoma. / Mazzucchelli, Roberta; Cheng, Liang; Lopez-Beltran, Antonio; Scarpelli, Marina; Montironi, Rodolfo.

In: Analytical and Quantitative Cytology and Histology, Vol. 34, No. 4, 08.2012, p. 173-179.

Research output: Contribution to journalArticle

Mazzucchelli, R, Cheng, L, Lopez-Beltran, A, Scarpelli, M & Montironi, R 2012, 'Clinicopathological significance of lymphovascular invasion in urothelial carcinoma', Analytical and Quantitative Cytology and Histology, vol. 34, no. 4, pp. 173-179.
Mazzucchelli, Roberta ; Cheng, Liang ; Lopez-Beltran, Antonio ; Scarpelli, Marina ; Montironi, Rodolfo. / Clinicopathological significance of lymphovascular invasion in urothelial carcinoma. In: Analytical and Quantitative Cytology and Histology. 2012 ; Vol. 34, No. 4. pp. 173-179.
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