In this review article, Kapur and colleague evaluate the potential role of clonal hematopoiesis of indeterminate potential (CHIP) in donor-derived leukemia, a significant complication of hematopoietic stem cell transplantation (HSCT). CHIP affects HSCT outcomes and may promote donor-derived leukemia via multiple cell-autonomous and non-cell-autonomous mechanisms. CHIP may be a novel risk factor for donor-derived leukemia with broad implications.
- clonal hematopoiesis
- hematopoietic stem cell transplantation
ASJC Scopus subject areas
- Developmental Biology
- Cell Biology