Clonal Hematopoiesis of Indeterminate Potential as a Novel Risk Factor for Donor-Derived Leukemia

Sarah S. Burns, Reuben Kapur

Research output: Contribution to journalReview article

Abstract

In this review article, Kapur and colleague evaluate the potential role of clonal hematopoiesis of indeterminate potential (CHIP) in donor-derived leukemia, a significant complication of hematopoietic stem cell transplantation (HSCT). CHIP affects HSCT outcomes and may promote donor-derived leukemia via multiple cell-autonomous and non-cell-autonomous mechanisms. CHIP may be a novel risk factor for donor-derived leukemia with broad implications.

Original languageEnglish (US)
Pages (from-to)279-291
Number of pages13
JournalStem Cell Reports
Volume15
Issue number2
DOIs
StatePublished - Aug 11 2020

Keywords

  • clonal hematopoiesis
  • hematopoietic stem cell transplantation
  • leukemia
  • lymphoma

ASJC Scopus subject areas

  • Biochemistry
  • Genetics
  • Developmental Biology
  • Cell Biology

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