Clonality analysis in modern oncology and surgical pathology

Liang Cheng, Shaobo Zhang, Timothy D. Jones, Deborah E. Blue

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


CUP represents a group of biologically and clinically heterogenous tumors. Management of patients with CUP requires a truly multi-disciplinary approach and close communications between the pathologists and oncologists to ensure an effective work-up. A variety of clonality analysis methodologies can be employed to determine a site of origin for the metastatic lesion. Gene and protein expression profiling technologies are potentially of great benefit in the identification of a primary tumor and may aid in the accurate assessment of prognosis. The identification of CUP-specific molecular signatures may offer new avenues for diagnosis and treatment.

Original languageEnglish (US)
Title of host publicationMolecular Genetic Pathology
PublisherHumana Press
Number of pages41
ISBN (Print)9781588299741
StatePublished - Dec 1 2008

ASJC Scopus subject areas

  • Medicine(all)

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    Cheng, L., Zhang, S., Jones, T. D., & Blue, D. E. (2008). Clonality analysis in modern oncology and surgical pathology. In Molecular Genetic Pathology (pp. 261-301). Humana Press.