Clonally related composite follicular lymphoma and mantle cell lymphoma with clinicopathologic features and biological implications

Shi Wang, Alexander Tzankov, Zijun Y. Xu-Monette, Sylvia Hoeller, Sa A. Wang, Kristy L. Richards, Shanxiang Zhang, Jonathan W. Said, L. Jeffrey Medeiros, Ken H. Young

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Composite lymphoma with follicular lymphoma (FL) and mantle cell lymphoma (MCL) components is rare and can pose a substantial diagnostic challenge. We report two cases of composite lymphoma with FL and MCL components occurring in lymph nodes. Both cases showed near total effacement of the lymph node architecture by grade 1 FL (CD10+ and BCL2+) with accompanying in situ MCL component (CD5+ and cyclin D1+) surrounding neoplastic follicles. The diagnosis of composite FL and MCL was confirmed by detecting the t(14;18)(q32;q21) and t(11;14)(q13;q32) in the FL and MCL components, respectively. Immunoglobulin heavy chain fragment length analysis in both cases showed identical dominant monoclonal peaks in microdissected neoplastic lymphoid cells from FL and MCL components. These findings suggest a common clonal origin for the FL and MCL components in both cases.

Original languageEnglish (US)
Pages (from-to)2658-2667
Number of pages10
JournalHuman pathology
Volume44
Issue number12
DOIs
StatePublished - Dec 1 2013

Keywords

  • Clonal relationship
  • Composite lymphoma
  • FISH
  • Follicular lymphoma
  • IgH
  • Mantle cell lymphoma
  • RLP

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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    Wang, S., Tzankov, A., Xu-Monette, Z. Y., Hoeller, S., Wang, S. A., Richards, K. L., Zhang, S., Said, J. W., Medeiros, L. J., & Young, K. H. (2013). Clonally related composite follicular lymphoma and mantle cell lymphoma with clinicopathologic features and biological implications. Human pathology, 44(12), 2658-2667. https://doi.org/10.1016/j.humpath.2013.07.007