Closest distance between tumor and resection margin in radical prostatectomy specimens

Lack of prognostic significance

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Complete removal of the tumor by surgery offers the best chance for cancer cure; however, many prostate cancer patients who have negative surgical margins at radical prostatectomy will still experience local and distant tumor recurrence. In other organs, the closest distance between tumor and resection margin has prognostic significance. This has not been adequately studied in prostatectomy specimens. We undertook a prospective study of 278 consecutive margin-negative whole-mount prostatectomy cases. The anatomic location and closest distance between tumor and resection margin, measured with an ocular micrometer, were analyzed. All the slides were reviewed by a single pathologist, and data were collected prospectively. The closest distance between tumor and resection margin ranged from 0.02 to 5.0 mm (mean, 0.7 mm; median, 0.5 mm) and correlated with patient age (P = 0.03), prostate weight (P = 0.002), Gleason score (P = 0.001), pathologic stage (P = 0.01), tumor volume (P < 0.001 ), and perineural invasion (P < 0.001). The closest distance between tumor and resection margin was not a significant predictor of PSA recurrence in univariate or multivariate logistic regression; and we do not, therefore, advocate reporting the closest distance between tumor and resection margin as a standard part of the surgical pathology report on prostatectomy specimens.

Original languageEnglish
Pages (from-to)225-229
Number of pages5
JournalAmerican Journal of Surgical Pathology
Volume29
Issue number2
DOIs
StatePublished - Feb 2005

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Prostatectomy
Neoplasms
Recurrence
Surgical Pathology
Margins of Excision
Neoplasm Grading
Tumor Burden
Prostate
Prostatic Neoplasms
Logistic Models
Prospective Studies
Weights and Measures

Keywords

  • Adenocarcinoma
  • Prostatic neoplasm
  • Radical prostatectomy
  • Staging
  • Surgical margins
  • Tumor volume

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

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title = "Closest distance between tumor and resection margin in radical prostatectomy specimens: Lack of prognostic significance",
abstract = "Complete removal of the tumor by surgery offers the best chance for cancer cure; however, many prostate cancer patients who have negative surgical margins at radical prostatectomy will still experience local and distant tumor recurrence. In other organs, the closest distance between tumor and resection margin has prognostic significance. This has not been adequately studied in prostatectomy specimens. We undertook a prospective study of 278 consecutive margin-negative whole-mount prostatectomy cases. The anatomic location and closest distance between tumor and resection margin, measured with an ocular micrometer, were analyzed. All the slides were reviewed by a single pathologist, and data were collected prospectively. The closest distance between tumor and resection margin ranged from 0.02 to 5.0 mm (mean, 0.7 mm; median, 0.5 mm) and correlated with patient age (P = 0.03), prostate weight (P = 0.002), Gleason score (P = 0.001), pathologic stage (P = 0.01), tumor volume (P < 0.001 ), and perineural invasion (P < 0.001). The closest distance between tumor and resection margin was not a significant predictor of PSA recurrence in univariate or multivariate logistic regression; and we do not, therefore, advocate reporting the closest distance between tumor and resection margin as a standard part of the surgical pathology report on prostatectomy specimens.",
keywords = "Adenocarcinoma, Prostatic neoplasm, Radical prostatectomy, Staging, Surgical margins, Tumor volume",
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AU - Cheng, Liang

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