Clozapine treatment of outpatients with schizophrenia: Outcome and long- term response patterns

Alan Breier, R. W. Buchanan, D. Irish, W. T. Carpenter

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

Objective: The purpose of the study was to examine the effects of clozapine in treating moderately ill schizophrenic outpatients and to determine the length of medication trial needed to identify responders and nonresponders. Methods: Rates of clinical response, relapses and hospitalizations, and levels of symptomatology and functioning were assessed for 30 chronic schizophrenic outpatients who received clozapine for one year. For some patients, data on relapse and hospitalization during treatment were compared with data from the year before treatment. Results: Eighteen of the 30 patients met criteria for sustained response; 17 of the responders were identified within the first four months of treatment. Patients experienced significantly fewer relapses and hospitalizations during treatment than in the previous year. Improvement in positive symptoms, general symptomatology, and levels of functioning reached a plateau during the first six months of treatment and remained at that level during the second six months. Negative symptoms and quality of life showed nonsignificant improvements at 12 months. Conclusions: Results support the use of clozapine in treating chronic, residually symptomatic schizophrenic outpatients. A four-month clozapine trial may be adequate to detect clinical responders in this population.

Original languageEnglish (US)
Pages (from-to)1145-1149
Number of pages5
JournalHospital and Community Psychiatry
Volume44
Issue number12
StatePublished - 1993
Externally publishedYes

Fingerprint

Clozapine
Schizophrenia
Outpatients
Hospitalization
Recurrence
Therapeutics
Quality of Life
Population

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Clozapine treatment of outpatients with schizophrenia : Outcome and long- term response patterns. / Breier, Alan; Buchanan, R. W.; Irish, D.; Carpenter, W. T.

In: Hospital and Community Psychiatry, Vol. 44, No. 12, 1993, p. 1145-1149.

Research output: Contribution to journalArticle

Breier, Alan ; Buchanan, R. W. ; Irish, D. ; Carpenter, W. T. / Clozapine treatment of outpatients with schizophrenia : Outcome and long- term response patterns. In: Hospital and Community Psychiatry. 1993 ; Vol. 44, No. 12. pp. 1145-1149.
@article{573a9710db5a48a391e36ffe3adf9c72,
title = "Clozapine treatment of outpatients with schizophrenia: Outcome and long- term response patterns",
abstract = "Objective: The purpose of the study was to examine the effects of clozapine in treating moderately ill schizophrenic outpatients and to determine the length of medication trial needed to identify responders and nonresponders. Methods: Rates of clinical response, relapses and hospitalizations, and levels of symptomatology and functioning were assessed for 30 chronic schizophrenic outpatients who received clozapine for one year. For some patients, data on relapse and hospitalization during treatment were compared with data from the year before treatment. Results: Eighteen of the 30 patients met criteria for sustained response; 17 of the responders were identified within the first four months of treatment. Patients experienced significantly fewer relapses and hospitalizations during treatment than in the previous year. Improvement in positive symptoms, general symptomatology, and levels of functioning reached a plateau during the first six months of treatment and remained at that level during the second six months. Negative symptoms and quality of life showed nonsignificant improvements at 12 months. Conclusions: Results support the use of clozapine in treating chronic, residually symptomatic schizophrenic outpatients. A four-month clozapine trial may be adequate to detect clinical responders in this population.",
author = "Alan Breier and Buchanan, {R. W.} and D. Irish and Carpenter, {W. T.}",
year = "1993",
language = "English (US)",
volume = "44",
pages = "1145--1149",
journal = "Psychiatric Services",
issn = "1075-2730",
publisher = "American Psychiatric Association",
number = "12",

}

TY - JOUR

T1 - Clozapine treatment of outpatients with schizophrenia

T2 - Outcome and long- term response patterns

AU - Breier, Alan

AU - Buchanan, R. W.

AU - Irish, D.

AU - Carpenter, W. T.

PY - 1993

Y1 - 1993

N2 - Objective: The purpose of the study was to examine the effects of clozapine in treating moderately ill schizophrenic outpatients and to determine the length of medication trial needed to identify responders and nonresponders. Methods: Rates of clinical response, relapses and hospitalizations, and levels of symptomatology and functioning were assessed for 30 chronic schizophrenic outpatients who received clozapine for one year. For some patients, data on relapse and hospitalization during treatment were compared with data from the year before treatment. Results: Eighteen of the 30 patients met criteria for sustained response; 17 of the responders were identified within the first four months of treatment. Patients experienced significantly fewer relapses and hospitalizations during treatment than in the previous year. Improvement in positive symptoms, general symptomatology, and levels of functioning reached a plateau during the first six months of treatment and remained at that level during the second six months. Negative symptoms and quality of life showed nonsignificant improvements at 12 months. Conclusions: Results support the use of clozapine in treating chronic, residually symptomatic schizophrenic outpatients. A four-month clozapine trial may be adequate to detect clinical responders in this population.

AB - Objective: The purpose of the study was to examine the effects of clozapine in treating moderately ill schizophrenic outpatients and to determine the length of medication trial needed to identify responders and nonresponders. Methods: Rates of clinical response, relapses and hospitalizations, and levels of symptomatology and functioning were assessed for 30 chronic schizophrenic outpatients who received clozapine for one year. For some patients, data on relapse and hospitalization during treatment were compared with data from the year before treatment. Results: Eighteen of the 30 patients met criteria for sustained response; 17 of the responders were identified within the first four months of treatment. Patients experienced significantly fewer relapses and hospitalizations during treatment than in the previous year. Improvement in positive symptoms, general symptomatology, and levels of functioning reached a plateau during the first six months of treatment and remained at that level during the second six months. Negative symptoms and quality of life showed nonsignificant improvements at 12 months. Conclusions: Results support the use of clozapine in treating chronic, residually symptomatic schizophrenic outpatients. A four-month clozapine trial may be adequate to detect clinical responders in this population.

UR - http://www.scopus.com/inward/record.url?scp=0027131763&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027131763&partnerID=8YFLogxK

M3 - Article

C2 - 8132186

AN - SCOPUS:0027131763

VL - 44

SP - 1145

EP - 1149

JO - Psychiatric Services

JF - Psychiatric Services

SN - 1075-2730

IS - 12

ER -