Co-administration of ethanol and nicotine

The enduring alterations in the rewarding properties of nicotine and glutamate activity within the mesocorticolimbic system of female alcohol-preferring (P) rats

Gerald A. Deehan, Sheketha R. Hauser, R. Aaron Waeiss, Christopher P. Knight, Jamie E. Toalston, William Truitt, William J. McBride, Zachary Rodd

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Rationale: The co-abuse of ethanol (EtOH) and nicotine (NIC) increases the likelihood that an individual will relapse to drug use while attempting to maintain abstinence. There is limited research examining the consequences of long-term EtOH and NIC co-abuse. Objectives: The current experiments determined the enduring effects of chronic EtOH, NIC, or EtOH∈+∈NIC intake on the reinforcing properties of NIC and glutamate (GLU) activity within the mesocorticolimbic (MCL) system. Methods: Alcohol-preferring (P) rats self-administered EtOH, Sacc∈+∈NIC, or EtOH∈+∈NIC combined for 10 weeks. The reinforcing properties of 0.1-3.0 μM NIC within the nucleus accumbens shell (AcbSh) were assessed following a 2-3-week drug-free period using intracranial self-administration (ICSA) procedures. The effects of EtOH, Sacc, Sacc∈+∈NIC, or EtOH∈+∈NIC intake on extracellular levels and clearance of glutamate (GLU) in the medial prefrontal cortex (mPFC) were also determined. Results: Binge intake of EtOH (96-100 mg%) and NIC (21-27 mg/mL) were attained. All groups of P rats self-infused 3.0 μM NIC directly into the AcbSh, whereas only animals in the EtOH∈+∈NIC co-abuse group self-infused the 0.3 and 1.0 μM NIC concentrations. Additionally, self-administration of EtOH∈+∈NIC, but not EtOH, Sacc or Sacc∈+∈NIC, resulted in enduring increases in basal extracellular GLU levels in the mPFC. Conclusions: Overall, the co-abuse of EtOH∈+∈NIC produced enduring neuronal alterations within the MCL which enhanced the rewarding properties of NIC in the AcbSh and elevated extracellular GLU levels within the mPFC.

Original languageEnglish (US)
Pages (from-to)4293-4302
Number of pages10
JournalPsychopharmacology
Volume232
Issue number23
DOIs
StatePublished - Aug 26 2015

Fingerprint

Nicotine
Glutamic Acid
Ethanol
Alcohols
Prefrontal Cortex
Self Administration
Nucleus Accumbens
Pharmaceutical Preparations

Keywords

  • Alcohol
  • Co-abuse
  • Intracranial self-administration
  • Medial prefrontal cortex
  • Nicotine
  • Nucleus accumbens

ASJC Scopus subject areas

  • Pharmacology

Cite this

Co-administration of ethanol and nicotine : The enduring alterations in the rewarding properties of nicotine and glutamate activity within the mesocorticolimbic system of female alcohol-preferring (P) rats. / Deehan, Gerald A.; Hauser, Sheketha R.; Waeiss, R. Aaron; Knight, Christopher P.; Toalston, Jamie E.; Truitt, William; McBride, William J.; Rodd, Zachary.

In: Psychopharmacology, Vol. 232, No. 23, 26.08.2015, p. 4293-4302.

Research output: Contribution to journalArticle

Deehan, Gerald A. ; Hauser, Sheketha R. ; Waeiss, R. Aaron ; Knight, Christopher P. ; Toalston, Jamie E. ; Truitt, William ; McBride, William J. ; Rodd, Zachary. / Co-administration of ethanol and nicotine : The enduring alterations in the rewarding properties of nicotine and glutamate activity within the mesocorticolimbic system of female alcohol-preferring (P) rats. In: Psychopharmacology. 2015 ; Vol. 232, No. 23. pp. 4293-4302.
@article{d8d2bacc3dbb473cb0b20864abd63db4,
title = "Co-administration of ethanol and nicotine: The enduring alterations in the rewarding properties of nicotine and glutamate activity within the mesocorticolimbic system of female alcohol-preferring (P) rats",
abstract = "Rationale: The co-abuse of ethanol (EtOH) and nicotine (NIC) increases the likelihood that an individual will relapse to drug use while attempting to maintain abstinence. There is limited research examining the consequences of long-term EtOH and NIC co-abuse. Objectives: The current experiments determined the enduring effects of chronic EtOH, NIC, or EtOH∈+∈NIC intake on the reinforcing properties of NIC and glutamate (GLU) activity within the mesocorticolimbic (MCL) system. Methods: Alcohol-preferring (P) rats self-administered EtOH, Sacc∈+∈NIC, or EtOH∈+∈NIC combined for 10 weeks. The reinforcing properties of 0.1-3.0 μM NIC within the nucleus accumbens shell (AcbSh) were assessed following a 2-3-week drug-free period using intracranial self-administration (ICSA) procedures. The effects of EtOH, Sacc, Sacc∈+∈NIC, or EtOH∈+∈NIC intake on extracellular levels and clearance of glutamate (GLU) in the medial prefrontal cortex (mPFC) were also determined. Results: Binge intake of EtOH (96-100 mg{\%}) and NIC (21-27 mg/mL) were attained. All groups of P rats self-infused 3.0 μM NIC directly into the AcbSh, whereas only animals in the EtOH∈+∈NIC co-abuse group self-infused the 0.3 and 1.0 μM NIC concentrations. Additionally, self-administration of EtOH∈+∈NIC, but not EtOH, Sacc or Sacc∈+∈NIC, resulted in enduring increases in basal extracellular GLU levels in the mPFC. Conclusions: Overall, the co-abuse of EtOH∈+∈NIC produced enduring neuronal alterations within the MCL which enhanced the rewarding properties of NIC in the AcbSh and elevated extracellular GLU levels within the mPFC.",
keywords = "Alcohol, Co-abuse, Intracranial self-administration, Medial prefrontal cortex, Nicotine, Nucleus accumbens",
author = "Deehan, {Gerald A.} and Hauser, {Sheketha R.} and Waeiss, {R. Aaron} and Knight, {Christopher P.} and Toalston, {Jamie E.} and William Truitt and McBride, {William J.} and Zachary Rodd",
year = "2015",
month = "8",
day = "26",
doi = "10.1007/s00213-015-4056-1",
language = "English (US)",
volume = "232",
pages = "4293--4302",
journal = "Psychopharmacology",
issn = "0033-3158",
publisher = "Springer Verlag",
number = "23",

}

TY - JOUR

T1 - Co-administration of ethanol and nicotine

T2 - The enduring alterations in the rewarding properties of nicotine and glutamate activity within the mesocorticolimbic system of female alcohol-preferring (P) rats

AU - Deehan, Gerald A.

AU - Hauser, Sheketha R.

AU - Waeiss, R. Aaron

AU - Knight, Christopher P.

AU - Toalston, Jamie E.

AU - Truitt, William

AU - McBride, William J.

AU - Rodd, Zachary

PY - 2015/8/26

Y1 - 2015/8/26

N2 - Rationale: The co-abuse of ethanol (EtOH) and nicotine (NIC) increases the likelihood that an individual will relapse to drug use while attempting to maintain abstinence. There is limited research examining the consequences of long-term EtOH and NIC co-abuse. Objectives: The current experiments determined the enduring effects of chronic EtOH, NIC, or EtOH∈+∈NIC intake on the reinforcing properties of NIC and glutamate (GLU) activity within the mesocorticolimbic (MCL) system. Methods: Alcohol-preferring (P) rats self-administered EtOH, Sacc∈+∈NIC, or EtOH∈+∈NIC combined for 10 weeks. The reinforcing properties of 0.1-3.0 μM NIC within the nucleus accumbens shell (AcbSh) were assessed following a 2-3-week drug-free period using intracranial self-administration (ICSA) procedures. The effects of EtOH, Sacc, Sacc∈+∈NIC, or EtOH∈+∈NIC intake on extracellular levels and clearance of glutamate (GLU) in the medial prefrontal cortex (mPFC) were also determined. Results: Binge intake of EtOH (96-100 mg%) and NIC (21-27 mg/mL) were attained. All groups of P rats self-infused 3.0 μM NIC directly into the AcbSh, whereas only animals in the EtOH∈+∈NIC co-abuse group self-infused the 0.3 and 1.0 μM NIC concentrations. Additionally, self-administration of EtOH∈+∈NIC, but not EtOH, Sacc or Sacc∈+∈NIC, resulted in enduring increases in basal extracellular GLU levels in the mPFC. Conclusions: Overall, the co-abuse of EtOH∈+∈NIC produced enduring neuronal alterations within the MCL which enhanced the rewarding properties of NIC in the AcbSh and elevated extracellular GLU levels within the mPFC.

AB - Rationale: The co-abuse of ethanol (EtOH) and nicotine (NIC) increases the likelihood that an individual will relapse to drug use while attempting to maintain abstinence. There is limited research examining the consequences of long-term EtOH and NIC co-abuse. Objectives: The current experiments determined the enduring effects of chronic EtOH, NIC, or EtOH∈+∈NIC intake on the reinforcing properties of NIC and glutamate (GLU) activity within the mesocorticolimbic (MCL) system. Methods: Alcohol-preferring (P) rats self-administered EtOH, Sacc∈+∈NIC, or EtOH∈+∈NIC combined for 10 weeks. The reinforcing properties of 0.1-3.0 μM NIC within the nucleus accumbens shell (AcbSh) were assessed following a 2-3-week drug-free period using intracranial self-administration (ICSA) procedures. The effects of EtOH, Sacc, Sacc∈+∈NIC, or EtOH∈+∈NIC intake on extracellular levels and clearance of glutamate (GLU) in the medial prefrontal cortex (mPFC) were also determined. Results: Binge intake of EtOH (96-100 mg%) and NIC (21-27 mg/mL) were attained. All groups of P rats self-infused 3.0 μM NIC directly into the AcbSh, whereas only animals in the EtOH∈+∈NIC co-abuse group self-infused the 0.3 and 1.0 μM NIC concentrations. Additionally, self-administration of EtOH∈+∈NIC, but not EtOH, Sacc or Sacc∈+∈NIC, resulted in enduring increases in basal extracellular GLU levels in the mPFC. Conclusions: Overall, the co-abuse of EtOH∈+∈NIC produced enduring neuronal alterations within the MCL which enhanced the rewarding properties of NIC in the AcbSh and elevated extracellular GLU levels within the mPFC.

KW - Alcohol

KW - Co-abuse

KW - Intracranial self-administration

KW - Medial prefrontal cortex

KW - Nicotine

KW - Nucleus accumbens

UR - http://www.scopus.com/inward/record.url?scp=84945472577&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84945472577&partnerID=8YFLogxK

U2 - 10.1007/s00213-015-4056-1

DO - 10.1007/s00213-015-4056-1

M3 - Article

VL - 232

SP - 4293

EP - 4302

JO - Psychopharmacology

JF - Psychopharmacology

SN - 0033-3158

IS - 23

ER -