Co-localization of molecules involved in antigen processing and presentation in an early endocytic compartment

Lynne E. Guagliardi, Bruce Koppelman, Janice S. Blum, Michael S. Marks, Peter Cresswell, Frances M. Brodsky

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Abstract

The pathways of intracellular traffic involved in antigen processing and presentation have been defined by immunoelectron microscopy. The export pathway for class II histocompatibility molecules and the antigen import pathway meet in a peripheral endocytic compartment having all the molecular machinery believed to be required for antigen processing and presentation, including internalized surface immunoglobulins, proteolytic enzymes and invariant chains. This compartment defines a site where peptides from endocytosed antigen can bind class II molecules en route to the cell surface for presentation to T cells.

Original languageEnglish (US)
Pages (from-to)133-139
Number of pages7
JournalNature
Volume343
Issue number6254
DOIs
StatePublished - Jan 1 1990

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Guagliardi, L. E., Koppelman, B., Blum, J. S., Marks, M. S., Cresswell, P., & Brodsky, F. M. (1990). Co-localization of molecules involved in antigen processing and presentation in an early endocytic compartment. Nature, 343(6254), 133-139. https://doi.org/10.1038/343133a0