Co-localization of molecules involved in antigen processing and presentation in an early endocytic compartment

Lynne E. Guagliardi, Bruce Koppelman, Janice Blum, Michael S. Marks, Peter Cresswell, Frances M. Brodsky

Research output: Contribution to journalArticle

287 Citations (Scopus)

Abstract

The pathways of intracellular traffic involved in antigen processing and presentation have been defined by immunoelectron microscopy. The export pathway for class II histocompatibility molecules and the antigen import pathway meet in a peripheral endocytic compartment having all the molecular machinery believed to be required for antigen processing and presentation, including internalized surface immunoglobulins, proteolytic enzymes and invariant chains. This compartment defines a site where peptides from endocytosed antigen can bind class II molecules en route to the cell surface for presentation to T cells.

Original languageEnglish (US)
Pages (from-to)133-139
Number of pages7
JournalNature
Volume343
Issue number6254
StatePublished - Jan 11 1990
Externally publishedYes

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Antigen Presentation
B-Cell Antigen Receptors
Immunoelectron Microscopy
Histocompatibility Antigens Class II
Endocytosis
Peptide Hydrolases
T-Lymphocytes
Antigens
Peptides

ASJC Scopus subject areas

  • General

Cite this

Guagliardi, L. E., Koppelman, B., Blum, J., Marks, M. S., Cresswell, P., & Brodsky, F. M. (1990). Co-localization of molecules involved in antigen processing and presentation in an early endocytic compartment. Nature, 343(6254), 133-139.

Co-localization of molecules involved in antigen processing and presentation in an early endocytic compartment. / Guagliardi, Lynne E.; Koppelman, Bruce; Blum, Janice; Marks, Michael S.; Cresswell, Peter; Brodsky, Frances M.

In: Nature, Vol. 343, No. 6254, 11.01.1990, p. 133-139.

Research output: Contribution to journalArticle

Guagliardi, LE, Koppelman, B, Blum, J, Marks, MS, Cresswell, P & Brodsky, FM 1990, 'Co-localization of molecules involved in antigen processing and presentation in an early endocytic compartment', Nature, vol. 343, no. 6254, pp. 133-139.
Guagliardi LE, Koppelman B, Blum J, Marks MS, Cresswell P, Brodsky FM. Co-localization of molecules involved in antigen processing and presentation in an early endocytic compartment. Nature. 1990 Jan 11;343(6254):133-139.
Guagliardi, Lynne E. ; Koppelman, Bruce ; Blum, Janice ; Marks, Michael S. ; Cresswell, Peter ; Brodsky, Frances M. / Co-localization of molecules involved in antigen processing and presentation in an early endocytic compartment. In: Nature. 1990 ; Vol. 343, No. 6254. pp. 133-139.
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